mutant list

Here is the list of mouse lines generated by LARGE under joint development with investigators in RIKEN or researchers in academic institutions. These mouse lines are available to the scientific community.

To request the mutant mouse line of your interest, please contact “mutant.bdr(at)riken.jp”.

Gene Targeting

Please scroll left and right to see

CDB Acc.No.

(BRC No.)

Genetic Sign mutation Type Corresponding Researcher Original paper
CDB0001K

(RBRC02575)

p53(-) Shinichi Aizawa Tsukada, T., Tomooka, Y., Takai, S., Ueda, Y., Nishikawa, S., Yagi, T., Tokunaga, T., Takeda, N., Suda, Y., Matsuo, I., Ikawa, Y. and Aizawa, S. (1993). Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene 8, 3313-3322.
CDB0002K tenascin(lacZ) Shinichi Aizawa Saga, Y., Yagi, T., Sakakura, T., Ikawa, Y. and Aizawa, S. (1992). Mice develop normally without tenascin. Genes Dev. 6, 1821-1823
CDB0003K fyn(lacZ) Shinichi Aizawa Yagi, T., Shigetani, Y., Okado, N., Ikawa, Y. and Aizawa, S. (1993). Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ. Oncogene 8, 3343-3351.
CDB0004K Csk(-) Shinichi Aizawa Nada, S., Yagi, T., Takeda, H., Tokunaga, T., Nakagawa, H., Ikawa, Y., Okada, M. and Aizawa, S.* (1993). Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73, 1125-1135.
CDB0005K

(RBRC02576)

mos(-) Shinichi Aizawa Hashimoto, N., Watanabe, N., Fruta, Y., Tamemoto, H., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. and Aizawa, S.* (1994). Parthenogenetic activation of oocytes, but normal spermatogenesis and somatic cell growth, by c-mos-deficiency in mice. Nature 370, 68-71.
CDB0006K Fak(-) Shinichi Aizawa Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S.* (1995). Reduced cell motility and enhanced focal adhesion contact formationin cells from FAK-deficient mice. Nature 377, 539-544.
CDB0007K Pat12 a gene trap clone Shinichi Aizawa Yoshida, M., Yagi, T., Furuta, Y., Takayanagi, K., Kominami, R., Takeda, N., Tokunaga, T., Chiba, J., Ikawa, Y. and Aizawa, S. (1995) A new strategy of gene trapping in ES cells using 3'RACE. Transgenic Res.,4, p277-287.
CDB0008K

Srm(-) Shinichi Aizawa Kohmura, N., Yagi, T., Tomooka, Y., Oyanagi, M., Kominami, R., Takeda, N., Chiba, J., Ikawa, Y. and Aizawa, S. (1994). A novel non-receptor tyrosine kinase, srm; cloning and targeted disruption. Mol. Cell. Biol. 14, 6915-6925.
CDB0009K fyn(Csk) Shinichi Aizawa Kanazawa, S., Ilic, D., Hashiyama, M., Okada, M., Nomura, T., Aizawa, S. and Suda, T. (1996). Impaired development of CD4+ CD8+ thymocytes by csk-"knock-in" into fyn locus. Oncogene 13, 199-204.
CDB0010K

(RBRC02270)

Otx2(-) Shinichi Aizawa Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. and Aizawa, S. (1995). Mouse Otx2 functions in the formation and patterning of rostral head. Genes & Dev. 9, 2646-2658.
CDB0011K

(RBRC02990)

Otx2(lacZ) Shinichi Aizawa Kimura, C., Yoshinaga, K., Tian, E., Suzuki, M., Aizawa, S., and Matsuo, I. (2000) Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Developmental Biology 225, 304-321.
CDB0012K Otx2 conditional Otx2frt Neo-d1 lox Shinichi Aizawa Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223.
CDB0013K

(RBRC02271)

Otx2 conditional KO flox Shinichi Aizawa Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223.
CDB0014K

(RBRC02998)

Otx2 conditional Δprox1 Shinichi Aizawa Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223.
CDB0015K Otx2(Otx1) Shinichi Aizawa Suda, Y., Nakabayashi, J., Matsuo, I. and Aizawa, S. (1999). Functional equivalency between Otx2 and Otx1 in development of the rostral head. Development 126, 743-757.
CDB0016K Otx2(Emx2) Shinichi Aizawa Suda, Y., Houssain, Z. M., Kobayashi, C., Hatano, O., Yoshida, M., Matsuo, I. and Aizawa, S. (2001). Emx2 directs the development of diencephalon in cooperation with Otx2. Development 128, 2433-2450.
CDB0017K

(RBRC02577)

Otx1(-) Shinichi Aizawa Suda, Y., Matsuo, I. and Aizawa, S. (1997). Cooperation between Otx1 and Otx2 genes in developemtal patterning of rostral brain. Mech. Dev. 69, 125-141.
CDB0018K Emx2(-) Shinichi Aizawa Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997). Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124, 101-111.
CDB0020K

(RBRC02272)

Emx2(Cre) Shinichi Aizawa Kimura, J., Suda, Y., Kurokawa, D., Houssain, ZM., Nakamura, M., Takahashi, M., Hara, A. and Aizawa, S. (2005) Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That Includes Future Archip-allium. The Journal of Neuroscience 25, 5097-5108.
CDB0021K

(RBRC02273)

Emx1(-) Shinichi Aizawa Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997). Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124, 101-111.
CDB0022K

(RBRC02578)

CHK/HYL(-) Shinichi Aizawa Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S.and Suda,T.(1996). Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Biochem. Biophys. Res. Commun. 224, 172-179. RBRC02578
CDB0024K

(RBRC02274)

ang(lacZ):4400 Shinichi Aizawa Murata, T., Furushima, K., Hirano, M., Kiyonari, H., Nakamura, M., Suda, Y. and Aizawa, S. (2004) ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Gene Expression Patterns 5, 171-178.
CDB0025K

(RBRC02275)

cfm(-): 5170 Shinichi Aizawa Hirano, M., Murata, T., Furushima, K., Kiyonari, H., Nakamura, M., Suda, Y. and Aizawa, S. (2005) cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype. Gene Expression Patterns, 5 439-444.
CDB0027K

(RBRC02276)

Opr(-) Shinichi Aizawa Furushima, K., Murata, T., Kiyonari, H. and Aizawa, S. (2005) Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedical telencephalon and medioventral forebrain (p NA). Developmental Dynamics 232, 1056-1061.
CDB0029K

(RBRC02277)

Omphk1(lacZ): 6057 Shinichi Aizawa Mariko Hirano, Hiroshi Kiyonari, Ai Inoue, Kenryo Furushima, Takuya Murata,Yoko Suda and Shinichi Aizawa (2006). A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. Developmental Dynamics 235, 2229-2237.
CDB0030K dkk1(Venus) Shinichi Aizawa Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492.
CDB0032K Epb4.1-like5(lacZ): 5156 Shinichi Aizawa Hirano, M., Hashimoto, S., Yonemura, S., Sabe, H. and Aizawa, S. (2008). EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. Journal of Cell Biology 182 1217-1230.
CDB0044K mShisa(lacZ): BS50-2 Shinichi Aizawa Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492.
CDB0045K mShisa3(lacZ): BS50-3 Shinichi Aizawa Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492.
CDB0046K mShisa4(lacZ): BS50-1 Shinichi Aizawa Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492.
CDB0047K mShisa5(IRES-lacz): BS50-4 Shinichi Aizawa Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492.
CDB0048K WISE KI(AFP) Nobue Itasaki Shigetani, Y., Howard, S., Guidato, S., Furushima, K., Abe, T. and Itasaki, N. Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. Developmental Biology, 319(Ⅱ),346-358,2008
CDB0049K

(RBRC02992)

Otx2(DAN) Shinichi Aizawa Kurokawa, D., Takasaki, N., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development, 131, 3307-3317.
CDB0050K

(RBRC02993)

Otx2(DFM1) Shinichi Aizawa Kurokawa, D., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development, 131, 3319-3331.
CDB0051K

(RBRC03078)

Otx2(DFM2) Shinichi Aizawa Kurokawa, D., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development, 131, 3319-3331.
CDB0064K Otx2(DFM1DFM2) Shinichi Aizawa Sakurai Y, Kurokawa D, Kiyonari H, Kajikawa E, Suda Y, Aizawa S. (2010) Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 347(2): 392-403.
CDB0071K

(RBRC05268)

microRNA9-3 KO(simple knock-out) Shinichi Aizawa Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S. (2011) MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 31(9): 3407-3422.
CDB0072K

(RBRC05269)

microRNA9-2 KO(simple knock-out) Shinichi Aizawa Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S. (2011) MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 31(9): 3407-3422.
CDB0075K Sfrp1(lacZ) Akihiko Shimono Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 133(6): 989-999.
CDB0076K Sfrp2(-) Akihiko Shimono Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 133(6): 989-999.
CDB0077K Sfrp5(-) Akihiko Shimono Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 46(2): 92-103.
CDB0078K Sfrp5(YFP) Akihiko Shimono Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 46(2): 92-103.
CDB0084K Epb4.1l5(loxP) conditional KO (loxP) Shinichi Aizawa Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB. (2017) The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Proc Natl Acad Sci U S A. 114(23):E4621-E4630.
CDB0089K AmotKO Akihiko Shimono Shimono A, Behringer RR. (2003) Angiomotin regulates visceral endoderm movements during mouse embryogenesis. Current Biology 13(7): 613-617.
CDB0092K Dkk1(H2B-mCherry) H2BmCherry KI Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0098K Hhex(CreERTM) CreERTM KI Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0103K DKK1(d2EGFP) degEGFP KI Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0201K

(RBRC05362)

FAH Shinichi Aizawa Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H. Flow Cytometric Isolation and Clonal Identification of Self-Renewing Bipotent Hepatic Progenitor Cells in Adult Mouse Liver. Hepatology, 48(6), 1964-1978, 2008
CDB0300K R26-TRE-memGFP(KI) Knockin Hirata Tatsumi Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019.
CDB0401K KCP(taulacZ): CR2X Yoshiki Sasai Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473.
CDB0402K Cv2(taulacZ): CR5 Yoshiki Sasai Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473.
CDB0403K ARID3B(lacZ-neo):DRI2 LacZ neo Shin-Ichi Nishikawa Takebe, A., Era, T., Okada, M., Jakt, LM., Kuroda, Y. and Nishikawa, S-I.
Microarray analysis of PDGFRa+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. Dev. Biol., 293, 25-37, 2006
CDB0404K

(RBRC03505)

Tead2 LacZ-KI Hiroshi Sasaki Sawada, A., Kiyonari, H., Ukita, K., Nishioka, N., Imuta, Y. and Sasaki, H. Redundant Roles Of Tead1 and Tead2 in Notochord Development and Regulation of Cell Proliferation and Survival.Mol Cell Biol., 28/10., 3177-3189, 2008
CDB0409K

(RBRC03506)

Tead4 LacZ-KI Hiroshi Sasaki Nishioka, N,. Yamamoto, S., Kiyonari, H., Sato, H., Sawada, A., Ota, M., Nakao, K. and Sasaki, H. Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.Mechanisms of Development., 125, 270-283, 2008
CDB0410K

(RBRC03507)

Tead1 LacZ-KI Hiroshi Sasaki Sawada, A., Kiyonari, H., Ukita, K., Nishioka, N., Imuta, Y. and Sasaki, H. Redundant Roles Of Tead1 and Tead2 in Notochord Development and Regulation of Cell Proliferation and Survival.Mol Cell Biol., 28/10., 3177-3189, 2008
CDB0411K

(RBRC02589)

mONT3(nlacZ): mONT1 KI(nLacZ) Yoshiki Sasai Ikeya, M., Kawada, M., Nakazawa, Y., Sakuragi, M., Sasai, N., Ueno, M., Kiyonari, H., Nakao, K.and Sasai, Y. Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations. Int J Dev Biol. 49(7), 807-823, 2005
CDB0412K ARID3B(lacZ):DRI2 LacZ Shin-Ichi Nishikawa Takebe, A., Era, T., Okada, M., Jakt, LM., Kuroda, Y. and Nishikawa, S-I.
Microarray analysis of PDGFRa+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells.
Dev. Biol., 293, 25-37, 2006
CDB0413K

(RBRC02590)

JamB(ires-β geo):Jcam2 KI(ires-β geo) Akihiko Okuda Sakaguchi, T., Nishimoto, M., Miyagi, S., Iwama, A., Morita, Y., Iwamori, N., Nkauchi, H., Kiyonari, H., Muramatsu, M.and Okuda, A.Putative "Sstemness"Gene Jam-b Is Not Required for Maintenance of Stem Cell State in Embryonic,Neural, or Hematopoietic Stem Cells. Mol Cell Biol.: 26(17), 6557-6570, 2006.
CDB0414K

(RBRC02591)

mGIT2 KO(simple knock-out) Hisataka Sabe Mazaki, Y., Hashimoto, S.,Tsujimura, Y., Morishige, M., Hashimoto, S., Aritake, K., Yamada, A., Jin-Min, Nam., Kiyonari, H., Nakao, K.and Sabe, H. Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nature Immunology : 7/7, 724-731, 2006.
CDB0419K

(RBRC11341)

mDia2 conditional Shuh Narumiya Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S. (2013) Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis. Cell Rep. 5(4): 926-32.
CDB0420K

(RBRC02593)

Tamalin KO(simple knock-out) Shigetada Nakanishi Ogawa, M., Miyakawa, T., Nakamura, K., Kitano, J., Furushima, K., Kiyonari, H., Nakayama, R., Nakao, K., Moriyoshi, K. and Nakanishi, S. Altered sensitivities to morphine and cocaine in scaffold proein tamalin knockout mice. Proc. Natl. Acad. Sci. USA: 104/37, 14789-14794, 2007.
CDB0422K

(RBRC02594)

septin-3(-) KO Mineko Kengaku Fujishima, K., Kiyonari, H., Kurisu, J., Hirano, T.and Kengaku, M.Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.J Neurochem.:102,1377-1388,2007
CDB0426K mDia3 conditional Shuh Narumiya Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S.A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.Nat Neurosci. 15(3):373-380, 2012.
CDB0427K

(RBRC09355)

SMAP1 KO(simple knock-out) Masanobu Satake Kon S, Minegishi N, Tanabe K, Watanabe T, Funaki T, Wong WF, Sakamoto D, Higuchi Y, Kiyonari H, Asano K, Iwakura Y, Fukumoto M,Osato M, Sanada M, Ogawa S, Nakamura T, Satake M. (2013) Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest.123(3):1123-37.
CDB0428K pp2C-epsilon KI(lacZ KI) Takayasu Kobayashi Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y, Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T. (2016) Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain. FEBS Lett. 590(20):3606-3615.
CDB0430K

(RBRC03508)

Slingshot3 LacZ-KI Tadashi Uemura Kousaka K, Kiyonari H, Oshima N, Nagafuchi A, Shima Y, ChisakaO, Uemura T.,Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development..:Genesis.45(5), 246-255, 2008.
CDB0431K

(RBRC05273)

mpk1(lacZ):mpk15 Naoto Ueno Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N. (2009) Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 106(34): 14426-14431.
CDB0433K

(RBRC05274)

Borealin:N196 Tatsutoshi Nakahata Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, Kitano A, Shiraishi K, Kato T, Nagato M, Okawa K, Furushima K, Nakao K, Nakamura Y, Taketo MM, Aizawa S, Nakahata T. (2008) Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 125(5-6): 441-450.
CDB0434K

(RBRC05275)

Vlk:24247(Venus-neo):24247-venus-LNL Shin-Ichi Nishikawa Kinoshita M, Era T, Jakt LM, Nishikawa S. (2009) The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development. 136(12): 2069-2079.
CDB0435K

(RBRC09345)

mpk2(-):mpk6 KO(simple knock-out) Naoto Ueno Tao H, Manak JR, Sowers L, Mei X, Kiyonari H, Abe T, Dahdaleh NS, Yang T, Wu S, Chen S, Fox MH, Gurnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaideb SN, El-Shanti H, Mahajan VB, Ferguson PJ, Axelrod JD, Lehesjoki AE, Fritzsch B, Slusarski DC, Wemmie J, Ueno N, Bassuk AG.Mutations in prickle orthologs cause seizures in flies, mice, and humans.Am J Hum Genet. 2011 Feb 11;88(2):138-49.
CDB0437K

(RBRC002595)

mDia1 KI(loxP, conditional) Shuh Narumiya Sakata, D., Taniguchi, H., Yasuda, S,. Adachi-Morishima,A., Hamazaki, Y., Nakayama, R., Miki, T., Minato, N. and Narumiya, S. Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. The Journal of Experimental Medicine:204/9, 2031-2038, 2007.
CDB0438K RGC Fantom 1 loxP KI Shinichi Nakagawa Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. (2016) Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 6:27204. doi: 10.1038/srep27204.
CDB0439K RGC Fantom 2 loxP KI Shinichi Nakagawa Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. (2016) Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 6:27204. doi: 10.1038/srep27204.
CDB0440K

(RBRC05276)

Kif-k Ryuichi Nishinakamura Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R. (2010) Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 107(20): 9240-9245.
CDB0442K

(RBRC03509)

TRB2(lacZ) LacZ-KI Ryuichi Nishinakamura Takasato M, Kobayashi C, Okabayashi K,Kiyonari H, Oshima N, Asashima M, Nishinakamura Ryuichi., Trb2, a mouse homeolog of tribble, is dispensable for kidney and mouse development.:Biochemical and Biophysical Research Communications.373, 648-652, 2008.
CDB0444K

(RBRC05277)

Fgf-bp3:N153 Tatsutoshi Nakahata Yamanaka Y, Kitano A, Takao K, Prasansuklab A, Mushiroda T, Yamazaki K, Kumada T, Shibata M, Takaoka Y, Awaya T, Kato T, Abe T, Iwata N, Miyakawa T, Nakamura Y, Nakahata T, Heike T.Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Mol Cell Neurosci. 2011 Jan;46(1):200-12.
CDB0445K TMX KO(simple knock-out) Junji Yodoi Matsuo, Y., Irie, K., Kiyonari, H., Okuyama, H., Nakamura, H., Son, A., Lopez-Ramos, DA., Tian, H., Oka, S., Okawa, K., Kizaka-Kondoh, S., Masutani, H. and Yodoi, J. (2013) The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury. Antioxid Redox Signal. 18(11): 1263-72.
CDB0451K Cv2(nlacZ): CR5 Yoshiki Sasai Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473.
CDB0452K

(RBRC003511)

LGN(loxP,venus):LGN-venusC KI(loxP, venus) Fumio Matsuzaki Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol. 10(1), 93-101, 2008.
CDB0454K

(RBRC05286)

Mdga1(-) KI(lacZ KI) Tohru Yamamoto Ishikawa T, Gotoh N, Murayama C, Abe T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T. (2011) IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Dev Dyn. 240(1): 96-107.
CDB0455K

(RBRC02596)

Ripply2 KI(lacZ KI) Makoto Asashima Chan T, Kondow A, Hosoya A, Hitachi K, Yukita A, Okabayashi K, Nakamura H, Ozawa H, Kiyonari H, Michiue T, Ito Y, Asashima M.(2007) Ripply2 is essential for precise somite formation during mouse early development. FEBS Letters 581,2691-2696
CDB0457K

(RBRC11336)

PKN3(-) KO(simple knock-out) Hideyuki Mukai Mukai, H., Muramatsu, A., Mashud, R., Kubouchi, K., Tsujimoto, S., Hongu, T., Kanaho, Y., Tsubaki, M., Nishida, S., Shioi, G., Danno, S., Mehruba, M., Satoh, R. and Sugiura, R. (2016) PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep. 6:18979. doi: 10.1038/srep18979.
CDB0463K

(RBRC05646)

PLCeta KI(lacZ KI) Kiyoko Fukami Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K.Phospholipase C-eta2 is highly expressed in the habenula and retina.Gene Expr Patterns. 2010 Feb-Mar;10(2-3):119-26. Epub 2010 Jan 11.
CDB0465K TTYH1 KO(simple knock-out) Tatsutoshi Nakahata Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, Okawa K, Abe T, Oshima N, Nakahata T, Heike T. (2010) Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 239(8): 2233-2245.
CDB0466K

(RBRC05280)

nrd1(lacZ) Eiichirou Nishi Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, Nishi E. (2009) Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 12(12): 1506-1513.
CDB0467K

(RBRC03512)

R-spondin2(lacZ):Cabriolet-2 LacZ-KI Hitoshi Okamoto Aoki M, Kiyonari H, Nakamura H, Okamoto H., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development.:Dev Growth Differ.50(2), 85-95, 2008.
CDB0468K CNOT6L(LacZ) KI(lacZ KI) Tadashi Yamamoto Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N. (2019) Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proc Natl Acad Sci U S A. 116(16):7973-7981.
CDB0471K

(RBRC09329)

Chemerin:AC1 KI(lacZ KI) Yutaka Takahashi Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS,Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y. Chemerin regulates β-cell function in mice. SCIENTIFIC REPORTS. 2011 Oct 19.
CDB0474K

(RBRC11340)

Dullard(lacZ) KI(lacZ KI) Ryuichi Nishinakamura Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R. Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428.
CDB0475K

(RBRC03513)

Intestine specific homeobox(Isn):Pix-1 LacZ-KI Susumu Seino Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S.Intestine specific homeobox (ISX) participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15, 15'-monooxygenase (bcmo1) expression.J Biol Chem. 283.4905-4911.2008
CDB0476K

(RBRC03514)

hrs(loxP) Kazuo Sugamura
Nobuyuki Tanaka
Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N, Watanabe M, Sugamura K. (2008) Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am J Pathol. 173(6): 1806-1817.
CDB0478K LMIR3 KO(simple knock-out) Jiro Kitaura Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J. (2012). The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37(5):827-39.
CDB0479K

(RBRC03515)

Aire(GFP):Aire-KI KI(GFP) Mitsuru Matsumoto Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, and Matsumoto M.(2008)Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.JEM.205.2827-2838 (*CDB0483K)
CDB0480K GPRC 5B KI(lacZ KI) Yoshio Hirabayashi T Sanoa, Y-J Kima, E Oshimaa, C Shimizu, H Kiyonari, T Abe, H Higashi, K Yamada, Y Hirabayashi. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Biochemical and Biophysical Research Communications 412 (2011) 460–465.
CDB0481K

(RBRC03516)

S gene(lacZ) LacZ-KI Mitsuru Matsumoto Matsumoto, M., Zhou, Y., Matsuo, S., Nakanishi, H., Hirose, K., Oura, H., Arase, S., Ishida-Yamamoto, A., Bando, Y., Izumi, K., Kiyonari, H., Oshima, N., Nakayama, R., Matsushima, A., Hirota, F., Mouri, Y., Kuroda, N., Sano, Shigetoshi. and David D. Chaplin. Tageted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc. Natl. Acad. Sci. : 105/18, 6720-6724, 2008.
CDB0482K Prox1 floxed Prox1 cDNA-KI, EGFP Fumio Matsuzaki Iwano T, Masuda A, Kiyonari H, Enomoto H, Matsuzaki F., Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus. Development. 2012 Aug;139(16):3051-62. Epub 2012 Jul 12.
CDB0483K

(RBRC03517)

RhoH(lacZ) KO(simple knock-out) Mutsunori Shirai Hiroyo Oda, Manabu Fujimoto, Michael S. Patrick, Dai Chida, Yoshinori Sato, Yoshinao Azuma, Hiroki Aoki, Takaya Abe, Harumi Suzuki and Mutsunori Shirai. (2009) RhoH Plays Critical Roles in FceRI-dependent Signal Transduction in Mast Cells. The Journal of Immunology,182: 957-962.
CDB0484K

(RBRC03518)

Draxin KI(lacZ KI) Yohei Shinmyo Shahidul M.Islam, Yohei Shinmyo, Tatsuya Okafuji, Yuhong Su, Iftekhar Bin Nase, Giasuddin Ahmed, Sanbing Zhang, Sandy Chen, Kunimasa Ohta, Hiroshi Kiyonari, Takaya Abe, Satomi Tanaka, Ryuichi Nishinakamura, Toshio Terashima, Toshio Kitamura, Hideaki Tanaka.(2009) Draxin, a Repulsive Guidanc Protein for Spinal Cord and Forebrain Commissures. Science 323,388-393.
CDB0485K GPRC 5C KI(lacZ KI) Yoshio Hirabayashi T Sanoa, Y-J Kima, E Oshimaa, C Shimizu, H Kiyonari, T Abe, H Higashi, K Yamada, Y Hirabayashi. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Biochemical and Biophysical Research Communications 412 (2011) 460–465.
CDB0487K Sox13 KI(lacZ KI) Shin-Ichi Osada Noto M, Noguchi N, Ishimura A, Kiyonari H, Abe T, Suzuki T, Hasunuma N, Taira M, Manabe M, Osada SI. Sox13 is a novel early marker for hair follicle development. Biochem Biophys Res Commun. 2019 Jan 10. pii: S0006-291X(18)32844-4. doi: 10.1016/j.bbrc.2018.12.163.
CDB0488K

(RBRC09352)

RECK Makoto Noda Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M. (2010). Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol 10:84. doi: 10.1186/1471-213X-10-84.
CDB0490K cdh8(gapLacZ/flox neo) Masatoshi Takeichi Suzuki SC, Furue H, Koga K, Jiang N, Nohmi M, Shimazaki Y, Katoh-Fukui Y, Yokoyama M, Yoshimura M, Takeichi M. (2007) Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 27(13): 3466-3476.
CDB0491K cdh8(tauLacZ/flox neo) Masatoshi Takeichi Suzuki SC, Furue H, Koga K, Jiang N, Nohmi M, Shimazaki Y, Katoh-Fukui Y, Yokoyama M, Yoshimura M, Takeichi M. (2007) Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 27(13): 3466-3476.
CDB0492K Cryptochrome2 KI(lacZ KI) Yoshitaka Fukada Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y. (2014). In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock. Mol Cell Biol. 34(24):4464-4473.
CDB0494K cdh6(-) Masatoshi Takeichi Inoue T., Tanaka T., Takeichi M., Chisaka O., Nakamura S., and Osumi N. (2001) Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development 128. 561-569.
CDB0495K cdh11(-) Masatoshi Takeichi Manabe T., Togashi H., Uchida N., Suzuki S.C., Hayakawa Y., Yamamoto M., Yoda H., Miyakawa T., Takeichi M., and Chisaka O. (2000) Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses. Mol Cell Neurosci 15. 534-546.
CDB0496K ctnna2(EGFP) Masatoshi Takeichi Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. (2002) Cadherin regulates dendritic spine morphogenesis. Neuron. 35(1): 77-89.
CDB0497K Fez(-):Fez(pgk-neo) Masahiko Hibi Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y.and Hibi, M. Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development. 133(8), 1433-1443, 2006
CDB0498K Fezl(lacZ):Fezl(LacZ-MC1-neo) Masahiko Hibi Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T.and Hibi, M. Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.Dev Dyn.230(3), 546-556, 2004
CDB0500K Dnmt1 Masaki Okano Takebayashi, S.I., Tamura, T., Matsuoka, C., and Okano, M. (2007).Major and Essential Role for the DNA Methylation Mark in Mouse Embryogenesis and Stable Association of DNMT1 with Newly Replicated Regions. Mol Cell Biol 27, 8243-8258.
CDB0502K

(RBRC03519)

Cthrc1 KI(lacZ KI) Hiroshi Sasaki Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.Dev. Cell 15, 23-36, 2008.
CDB0518K Ret-CreERT2 CreERT2 KI Hideki Enomoto Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F.(2009) Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell. 17(2): 199-209.
CDB0524K Runx-1(Mer-Cre-Mer):Runx-1(Mer-Cre-Mer, HSV TK -neo) Igor M Samokhvalov Samokhvalov IM, Samokhvalova NI, Nishikawa S. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007 Apr 26;446(7139):1056-61
CDB0525K

(RBRC05065)

Sox1(Cre) Shin-Ichi Nishikawa Takashima Y, Era T, Nakao K, Kondo S, Kasuga M, Smith AG, Nishikawa S. (2007) Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell. 129(7): 1377-1388.
CDB0530K pkd2 KO(simple knock-out) Takahiko Yokoyama Takao D, Nemoto T, Abe T, Kiyonari H, Kajiura-Kobayashi H, Shiratori H, Nonaka S. (2013) Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Dev Biol. 376(1):23-30.
CDB0531K

(RBRC05281)

LTbR KI(lacZ KI) Mitsuru Matsumoto Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M. Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma.J Immunol. 2011;186(9):5047-57.
CDB0535K

(RBRC04815)

NIPSNAP1 KO(simple knock-out) Emiko Ashitaka Okuda-Ashitaka E, Minami T, Tsubouchi S, Kiyonari H, Iwamatsu A, Noda T, Hanada H and Ito S. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem. 287(13), 10403-10413, 2012.
CDB0537K

(RBRC03520)

AW548124 KO Hiroshi Sasaki Imuta Y, Nishioka N, Kiyonari H, Sasaki H.Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124).Dev.Dyn. 238,210-222, 2009
CDB0539K

(RBRC05282)

LMIR5(Lenococyte-momo-lg-like receptor3) Toshio Kitamura Yamanishi Y, Kitaura J, Izaawa K, Kitani A, Komeno Y, Nakamra M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.(2010) TIM1 is an endogenous ligand for LMIR5/CD300b:LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.JEM 207,1501-1511.
CDB0540K CITED2 conditional Michihiro Matsumoto Tsukasaki, M., N. C. Huynh, K. Okamoto, R. Muro, A. Terashima, Y. Kurikawa, N. Komatsu, W. Pluemsakunthai, T. Nitta, T. Abe, H. Kiyonari, T. Okamura, M. Sakai, T. Matsukawa, M. Matsumoto, Y. Kobayashi, J. M. Penninger and H. Takayanagi (2020). Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab 2(12): 1382-1390.
CDB0542K Epac1 KO(simple knock-out) Yoshihiro Ishikawa Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato M, Okumura S, Ishikawa Y. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010 Jul 30;285(31):24248-59.
CDB0545K

(RBRC09343)

MOR215-1(swap) Hitoshi Sakano Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H. Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons. Cell. 2013 Sep 12;154(6):1314-25. doi: 10.1016/j.cell.2013.08.033.
CDB0546K

(RBRC09344)

MOR215-1(tagging) Hitoshi Sakano Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H. Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons. Cell. 2013 Sep 12;154(6):1314-25. doi: 10.1016/j.cell.2013.08.033.
CDB0547K TSK(lacZ) KI(lacZ KI) Kunimasa Ohta Ito, A., Shinmyo, Y., Abe, T., Oshima, N., Tanaka, H., Ohta, K. (2010). Tsukushi is required for anterior commissure formation in mouse brain. Biochem Biophys Res Commun. 402(4):813-8.
CDB0548K Dmrta4 KO Noriko Osumi Kikkawa, T., Sakayori, N., Yuuki, H., Katsuyama, Y., Matsuzaki, F., Konno, D., Abe, T., Kiyonari, H., and Osumi, N. (2020). Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon. Dev Dyn 249, 698-710.
CDB0549K IAN4(loxP) conditional Yousuke Takahama Yano, K., Carter, C., Yoshida, N., Abe, T., Yamada, A., Nitta, T., Ishimaru, N., Takada, K., Butcher, G. W. and Takahama, Y. (2014) Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol 44(2): 561-72.
CDB0552K PLCd1 conditional Kiyoko Fukami Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K.Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun. 2012 Jul 17;3:963. doi: 10.1038/ncomms1960.
CDB0553K

(RBRC03521)

PC/Glis3-exon5-Neo:pc/Glis3-GFP Yuko Wakamatsu Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H. (2009) A murine model of neonatal diabetes mellitus in Glis3-deficient mice. FEBS Lett. 583(12): 2108-2113.
CDB0555K

(RBRC09347)

NUAK1:Ark5 conditional Hiroyasu Esumi Inazuka F, Sugiyama N, Tomita M, Abe T, Shioi G, Esumi H. (2012) Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. J Biol Chem. 287(20):16379-16389.
CDB0557K Sirh11 conditional Tomoko Ishino Irie, M., Yoshikawa, M., Ono, R., Iwafune, H., Furuse, T., Yamada, I., Wakana, S., Yamashita, Y., Abe, T., Ishino, F., Kaneko-Ishino, T. (2015) Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians, PLoS Genet 11(9):e1005521.
CDB0558K Cbx3 conditional Yukiko Gotoh Oshiro H, Hirabayashi Y, Furuta Y, Okabe S, Gotoh Y. (2015) Up-regulation of HP1γexpression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex. Genes Cells. 20(2):108-20.
CDB0559K IAN5 KO(simple knock-out) Yousuke Takahama Yano, K., Carter, C., Yoshida, N., Abe, T., Yamada, A., Nitta, T., Ishimaru, N., Takada, K., Butcher, G. W. and Takahama, Y. (2014) Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol 44(2): 561-72.
CDB0564K

(RBRC09336)

Dullard conditional Ryuichi Nishinakamura Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R. (2013) The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth. Nat Commun. 4:1398. doi: 10.1038/ncomms2408.
CDB0570K

(RBRC11342)

Epac2 KO(simple knock-out) Yoshihiro Ishikawa Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. (2014) Epac1-dependent hospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest. 124(6):2785-2801. doi: 10.1172/JCI64784.
CDB0575K

(RBRC09339)

Hormad1 KO(simple knock-out) Hiroki Kurahashi Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012 ;17(6):439-54.
CDB0576K

(RBRC09340)

Hormad2 KO(simple knock-out) Hiroki Kurahashi Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H. (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 17(11): 897-912.
CDB0579K

(RBRC05283)

Noto(nmCherry-CreERT2) Hiroshi Sasaki Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H. (2009) Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev. 126(10): 791-803.
CDB0582K

(RBRC11337)

CLPABP KO(simple knock-out) Hisaaki Taniguchi Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H. (2016) Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim Biophys Acta. 1861(11):1816-1827.
CDB0583K DISC1 KO(simple knock-out) Kozo Kaibuchi Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K,Kaibuchi K., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.: Hum Mol Genet. 20(23), 4666-4683, 2011.
CDB0584K

(RBRC11345)

CNOT8(loxP) KO(simple knockout)
conditional KO
Suzuki Toru
Yamamoto Tadashi
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T. (2020) Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Jan 10:1-14.
CDB0585K CEB1/HERC5(-) KO(simple knock-out) Kunitada Shimotohno Arimoto K, Hishiki T, Kiyonari H, Abe T, Cheng C, Yan M, Fan JB, Futakuchi M, Tsuda H, Murakami Y, Suzuki H, Zhang DE, Shimotohno K. (2015) Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res. 35(5):351-8.
CDB0587K Sfrp4 lacZ-neo KI Sohei Kitazawa Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, Abe T, Kitazawa S. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198. doi: 10.1038/srep25198.
CDB0589K APBA3(loxP) conditional Motoharu Seiki Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T.Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.J Biol Chem. 2011 Sep 16;286(37):32542-51. Epub 2011 Jul 21.
CDB0590K

(RBRC09338)

GTRAP3-18 KO(simple knock-out) Toshio Nakaki Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M, Nakaki T. Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice. Neurobiol Dis. 2012 Mar;45(3):973-982.
CDB0597K Fhod1(lacZ):Fhod1/Fhos1 LacZ KI Sumimoto Hideki Sanematsu F, Kanai A, Ushijima T, Shiraishi A, Abe T, Kage Y, Sumimoto H, Takeya R. (2019) Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice. Cytoskeleton (Hoboken). 76(2):219-229.
CDB0599K

(RBRC05285)

Crtac1 KO(simple knock-out) Kohtaro Takei Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011 Aug 5;333(6043):769-73.
CDB0601K Foxa2(Foxa2-2A-nuc-EGFP-2A-CreER) KI Hiroshi Sasaki Imuta Y, Kiyonari H, Jang CW, Behringer RR, Sasaki H. (2013) Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar;51(3):210-8.
CDB0602K

(RBRC09332)

Arid5a KO(simple knock-out) Riko Nishimura Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T. (2013) Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc Natl Acad Sci U S A. 110(23): 9409-9414.
CDB0603K

(RBRC11343)

Tdrd5 KO(simple knock-out) Mitinori Saitou Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. (2011) TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 192(5): 781-95.
CDB0604K Brachyury(Brachyury2A-nuc-EGFP-2A-CreER) KI Hiroshi Sasaki Imuta Y, Kiyonari H, Jang CW, Behringer RR, Sasaki H. (2013) Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar;51(3):210-8.
CDB0605K USP10(loxP) conditional Masahiro Fujii Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M. (2016) USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Stem Cell Reports. 7(6):1116-1129.
CDB0606K DGKη KO(simple knock-out) Fumio Sakane Isozaki T, Komenoi S, Lu Q, Usuki T, Tomokata S, Matsutomo D, Sakai H, Bando K, Kiyonari H, Sakane F. (2016) Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior. J Neurochem.138(3), 448-456.
CDB0608K PCDH17(lacZ) KI(lacZ KI) Tadashi Yamamoto Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T. (2013) Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits. Neuron. 78(5):839-854.
CDB0609K Lrrk2(-) Nobuyuki Nukina Imai, Y., Kobayashi, Y., Inoshita, T., Meng, H., Arano, T., Uemura, K., Asano, T., Yoshimi, K., Zhang, C. L., Matsumoto, G., Ohtsuka, T., Kageyama, R., Kiyonari, H., Shioi, G., Nukina, N., Hattori, N. and Takahashi, R. (2015) The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet 11(9): e1005503.
CDB0610K CCR2 contact person
Yoshikazu Tamori
Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H. (2016) Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner. Cell Metab. 24(2):295-310.
CDB0612K

(RBRC09348)

P13 KI(lacZ KI) Masato Kasuga Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S-I, Itoh H. Novel repressor regulates insulin sensitivity through interaction with Foxo1.: The EMBO JOURNAL. online publication 17 April 2012.
CDB0618K ROSA26(HA-YAP-IRES-EGFP) Knockin Hiroshi Sasaki Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H. (2018). Obesity in Yap transgenic mice is associated with TAZ downregulation. Biochem Biophys Res Commun. 505(3):951-957.
CDB0623K

(RBRC05284)

Prominin1 (floxed-lacZ-DTA) Toru Kondo Nishide K, Nakatani Y, Kiyonari H, Kondo T. (2009) Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One. 4(8):e6869. doi: 10.1371/journal.pone.0006869.
CDB0625K Slc30a8 Hirotaka Watada Tamaki, M., Fujitani, Y., Hara, A., Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M., Watanabe, T., Ogihara, T., Fukunaka, A., Shimizu, T., Mita, T., Kanazawa, A., Imaizumi, MO., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Kawauchi, T., Nagamatsu, S., Hirano, T., Kawamori, R. and Watada, H. (2013) The diabetes-susceptible gene SLC30A8/ ZnT8 regulates hepatic insulin clearance. J Clin Invest. 123(10):4513-24.
CDB0627K

(RBRC09330)

Angpt1 conditional Yoshikazu Nakaoka Lee J, Kim KE, Choi DK, Jang JY, Jung JJ, Kiyonari H, Shioi G, Chang W, Suda T, Mochizuki N, Nakaoka Y, Komuro I, Yoo OJ, Koh GY. Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy. Sci Transl Med. 2013. 18;5(203)
CDB0628K

(RBRC09333)

C85492(-):Ago61 KO(simple knock-out) Koichi Kato Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, Khoo KH, Oka S, Kato K. (2013) AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan. Sci Rep. 3:3288. doi: 10.1038/srep03288.
CDB0630K Crag(loxP):CRAG/centurin gammma3 conditional Shigeru Yanagi Nagashima, S., K. Takeda, I. Shiiba, M. Higashi, T. Fukuda, T. Tokuyama, N. Matsushita, S. Nagano, T. Araki, M. Kaneko, G. Shioi, R. Inatome and S. Yanagi (2019). Critical role of CRAG, a splicing variant of centaurin-gamma3/AGAP3, in ELK1-dependent SRF activation at PML bodies. Sci Rep 9(1): 20107.
CDB0631K

(RBRC09341)

IL-33 Hirohisa Saito Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.(2010) IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A. 107(43): 18581-18586.
CDB0637K

(RBRC09335)

Dpysl3 Yoshio Goshima Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T. (2012) CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. Dev Neurobiol. 72(11): 1447-1457.
CDB0642K Dpysl2:CRMP2 KO(simple knock-out) Yoshio Goshima Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y. (2016) CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development. Genes Cells. 21(9):994-1005.
CDB0649K

(RBRC11333)

LPCAT2(loxP) Takao Shimizu Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. (2017) Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. FASEB J. 31(7):2973-2980.
CDB0653K

(RBRC11334)

LPCAT3(loxP) conditional Takao Shimizu Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. (2015). Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife. 4. doi: 10.7554/eLife.06328.
CDB0658K

(RBRC10155)

Ccdc141(loxP) Shigeru Yanagi Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S. (2016) Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep. 17(12):1785-1798.
CDB0659K Periostin(-) KO(simple knock-out) Yoshiaki Taniyama Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Abe T, Kiyonari H, Shioi G, Katsuragi N, Ishibashi T, Morishita R, Taniyama Y. (2016) Different roles played by periostin splice variants in retinal neovascularization. Exp Eye Res. 153:133-140.
CDB0660K DGKdelta-loxP conditional KO (loxP) Fumio Sakane Usuki T, Takato T, Lu Q, Sakai H, Bando K, Kiyonari H, Sakane, F. (2016) Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice. Brain Res. 1648 (Part A), 193–201.
CDB0672K Gpr176 tau-lacZ KI Hitoshi Okamura Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H. (2016) Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun. 7:10583. doi: 10.1038/ncomms10583.
CDB0674K PDGFRa-MerCreMer MerCreMer KI Shin-Ichi Nishikawa Ding G, Tanaka Y, Hayashi M, Nishikawa S, Kataoka H. (2013) PDGF receptor alpha+ mesoderm contributes to endothelial and hematopoietic cells in mice. Dev Dyn. 242(3): 254-268.
CDB0678K DISC1 KO(simple knock-out) Kozo Kaibuchi Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K,Kaibuchi K., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.: Hum Mol Genet. 20(23), 4666-4683, 2011.
CDB0679K Periostin(-) KO(simple knock-out) Yoshiaki Taniyama Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Abe T, Kiyonari H, Shioi G, Katsuragi N, Ishibashi T, Morishita R, Taniyama Y. (2016) Different roles played by periostin splice variants in retinal neovascularization. Exp Eye Res. 153:133-140.
CDB0683K

(RBRC09349)

PICALM KO(simple knock-out) Toshio Watanabe Suzuki M, Tanaka H, Tanimura A, Tanabe K, Oe N, Rai S, Kon S, Fukumoto, M, Takei K, Abe T, Matsumura I, Kanakura Y, and Watanabe T. (2012) The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS ONE 7(2): e31854.
CDB0693K

(RBRC09356)

Sp7:Osterix conditional Riko Nishimura Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shiho G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T.Osterix Regulates Calcification and Degradation of Chondrogenic Matrices Through Matrix Metalloproteinase (MMP13) Expression in Association with Transcription Factor Runx2 During Endochondral Ossification.J Biol Chem. 2012; 287(40):33179-33190.
CDB0694K MACS1:AK043126 KO(simple knock-out) Toshihiko Shiroishi Sagai T, Amano T, Maeno A, Kimura T, Nakamoto M, Takehana Y, Naruse K, Okada N, Kiyonari H, Shiroishi T. (2017) Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder. Nat Commun. 8:14300. doi: 10.1038/ncomms14300.
CDB0695K asrij(ociad1) conditional Maneesha Inamdar Sinha S, Dwivedi TR, Yengkhom R, Bheemsetty VA, Abe T, Kiyonari H, VijayRaghavan K, Inamdar MS. (2019) Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Blood. 133(22):2385-2400.
CDB0702K Arf1(-) KO(simple knock-out) Toshio Watanabe Hayakawa N, Ogoh H, Sumiyoshi M, Matsui Y, Nishikawa S, Miyamoto K, Maede Y, Kiyonari H, Suzuki M, Watanabe T. (2014) The ADP-ribosylation factor 1 gene is indispensable for mouse embryonic development after implantation. Biochem Biophys Res Commun. 453(4):748-53.
CDB0705K

(RBRC09357)

Spns2 conditional Naoki Mochizuki Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. The Journal of Clinical Investigation.122(4), 1416-1426, 2012.
CDB0706K DMT1-STOP-RasDA Yoshiteru Sasaki Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki JI, Duchen MR, Nam JM, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Sato T, Fujita Y. (2017). Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol. 19(5):530-541.
CDB0713K Tshb luciferase KI Hiroki Ueda Tsujino K, Narumi R, Masumoto KH, Susaki EA, Shinohara Y, Abe T, Iigo M, Wada A, Nagano M, Shigeyoshi Y, Ueda HR. Establishment of TSH β real-time monitoring system in mammalian photoperiodism. Genes Cells. 2013; 18(7), 575-588
CDB0716K CAMSAP3 conditional Masatoshi Takeichi Toya, M., Kobayashi, S., Kawasaki, M., Shioi, G., Kaneko, M., Ishiuchi, T., Misaki, K., Meng,.W, and Takeichi, M. (2016) CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells. Proc Natl Acad Sci U S A. 113(2):332-7.
CDB0740K MDGA2:FY29-2 KI(lacZ KI) Fumio Matsuzaki Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM. (2016) Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 91(5):1052-68.
CDB0743K Nrg1(loxP) conditional Shin-ichi Abe JiDong Zhang, Ko Eto, Asuka Honmyou, Kazuki Nakao, Hiroshi Kiyonari, and Shin-ichi Abe. Neuregulins are essential in spermatogonial proliferation and meiosis initiation in neonatal mouse testis. DEVELOPMENT 2011 in press.
CDB0758K aquaporin 4(GFP) EGFP KI Masato Yasui Ikeshima-Kataoka H, Abe Y, Abe T, Yasui M. (2013) Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin. Mol Cell Neurosci. 56, 65-75, 2013.
CDB0764K LMTK3 Tadashi Yamamoto Inoue, T., Hoshina, N., Nakazawa, T., Kiyama, Y., Kobayashi, S., Abe, T., Yamamoto, T., Manabe, T. and Yamamoto, T. (2014) LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci 34(17): 5927-37.
CDB0767K Vps52 conditional Kuniya Abe Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K. Molecular Identification of tw5: Vps52 Promotes Pluripotential Cell Differentiation through Cell-Cell Interactions. Cell Reports 2, 1-12, 2012.
CDB0768K NDRG2(lacZ) Kazuhiro Morishita Nakahata, S., Ichikawa, T., Maneesaay, P., Saito, Y., Nagai, K., Tamura, T., Manachai, N., Yamakawa, N., Hamasaki, M., Kitabayashi, I. Arai, Y., Kanai, Y., Taki, T., Abe, T., Kiyonari, H., Shimoda, K., Ohshima, K., Horii, A., Shima, H., Taniwaki, M., Yamaguchi, R. and Morishita, K. (2014) Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun 5: 3393.
CDB0773K NEAT1 KI(lacZ KI) Shinichi Nakagawa Nakagawa S, Naganuma T, Shioi G, Hirose T. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 2011 Apr 4;193(1):31-9.
CDB0774K Scn4b KO(simple knock-out) Nobuyuki Nukina Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N. (2014). Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 5:5525. doi: 10.1038/ncomms6525.
CDB0777K TSLP AFP KI Susumu Nakae Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S. (2018). IL-25 enhances T(H)17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells. J Allergy Clin Immunol. pii: S0091-6749(18)30326-9.
CDB0781K MRCS1:MH8 KO(simple knock-out) Toshihiko Shiroishi Sagai T, Amano T, Maeno A, Kiyonari H, Seo H, Cho SW, Shiroishi T. (2017) SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development. Sci Rep. 7(1):13004. doi: 10.1038/s41598-017-12532-y.
CDB0791K Phldb2(LL5β) conditional Makoto Sato Xie MJ, Ishikawa Y, Yagi H, Iguchi T, Oka Y, Kuroda K, Iwata K, Kiyonari H, Matsuda S, Matsuzaki, Yuzaki M, Fukazawa Y, Sato M. (2019) PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Sci Rep. 9(1):4305.
CDB0794K

(RBRC11344)

CNOT6(loxP) KO(simple knockout)
conditional KO
Yamamoto Tadashi
Suzuki Toru
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T. (2020) Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Jan 10:1-14.
CDB0796K R26R-YapS112A-IG:ROSA:HA-YapSA-IRES-EGFP Knockin Hiroshi Sasaki Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H. (2018). Obesity in Yap transgenic mice is associated with TAZ downregulation. Biochem Biophys Res Commun. 505(3):951-957.
CDB0799K

(RBRC09358)

Top1 conditional Tasuku Honjo Kobayashi M, Sabouri Z, Sabouri S, Kitawaki Y, Pommier Y, Abe T, Kiyonari H, Honjo T. Decrease in topoisomerase I is responsible for activation-induced cytidinedeaminase (AID)-dependent somatic hypermutation. Proc Natl Acad Sci USA.108(48), 19305-19310, 2011.
CDB0800K Kif26b conditional Ryuichi Nishinakamura Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R. (2015). Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 26(5):1081-1091.
CDB0801K Sdf2l1(loxP):Sdf2l1(stromal cell-derived factor 2-like 1) conditional Kadowaki Takashi Sasako, T., Ohsugi, M., Kubota, N., Itoh, S., Okazaki, Y., Terai, A., Kubota, T., Yamashita, S., Nakatsukasa, K., Kamura, T., Iwayama, K., Tokuyama, K., Kiyonari, H., Furuta, Y., Shibahara, J., Fukayama, M., Enooku, K., Okushin, K., Tsutsumi, T., Tateishi, R., Tobe, K., Asahara, H., Koike, K., Kadowaki, T., Ueki, K. (2019). Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun 10, 947.
CDB0803K claudin1 conditional KO (loxP) Akiharu Kubo Atsugi T, Yokouchi M, Hirano T, Hirabayashi A, Nagai T, Ohyama M, Abe T, Kaneko M, Zouboulis CC, Amagai M, Kubo A. (2019) Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1-Deficient Mice. J Invest Dermatol. pii: S0022-202X(19)33139-2.
CDB0814K Ras protein activator like 1(RASAL1) Masao Omata Takata A, Otsuka M, Kishikawa T, Yamagami M, Ishibashi R, Sekiba K, Suzuki T, Ohno M, Yamashita Y, Abe T, Masuzaki R, Ikenoue T, Koike K. (2017) RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget. 8(39):64840-64852.
CDB0816K Eef1d eukaryotic translation elongation factor 1 delta conditional Masayuki Matsushita Kaitsuka T, Kiyonari H, Shiraishi A, Tomizawa K, Matsushita M. (2018). Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. Front Mol Neurosci. 11:358. doi: 10.3389/fnmol.2018.00358.
CDB0818K claudin-1 conditional Sachiko Tsukita Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S. (2016) Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 113(28):E4061-8. doi: 10.1073/pnas.1525474113.
CDB0831K Agtr1a conditional KO (loxP) Takeshi Tokudome Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K. (2019) Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Circulation,141(7):571-588,2020
CDB0832K

(RBRC10433)

Runx2(loxP) conditional Yukio Yoneda Takarada T, Hinoi E, Nakazato R, Ochi H, Xu C, Tsuchikane A, Takeda S, Karsenty G, Abe T, Kiyonari H, Yoneda Y. (2013) An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res. 28(10): 2064-2069.
CDB0833K ifrd1 conditional Yukio Yoneda Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E. (2015) The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption. J Bone Miner Res. doi: 10.1002/jbmr.2720.
CDB0835K slc38A1(loxP) conditional Takeshi Takarada Yamada D, Kawabe K, Tosa I, Tsukamoto S, Nakazato R, Kou M, Fujikawa K, Nakamura S, Ono M, Oohashi T, Kaneko M, Go S, Hinoi E, Yoneda Y, Takarada T. (2019) Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Commun Biol. 2:346.
CDB0837K NEAT2 KI(lacZ KI) Shinichi Nakagawa Nakagawa S, Ip JY, Shioi G, Tripathi V, Zong X, Hirose T, Prasanth KV. Malat1 is not an essential component of nuclear speckles in mice. RNA. online June 20, 2012.
CDB0838K Pcdh17 KI(lacZ KI) Masatoshi Takeichi Hayashi S, Inoue Y, Kiyonari H, Abe T, Misaki K, Moriguchi H, Tanaka Y, Takeichi M. (2014) Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts. Dev Cell. 30(6):673-87.
CDB0839K Pcdh19(lacZ) Masatoshi Takeichi Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, Takeichi M. (2017) Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice. Sci Rep. 7(1):5801. doi:10.1038/s41598-017-06374-x.
CDB0840K Snx5 GFP KI contact person
Shingo Ichimiya
Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, Nagaya T, Yamashita K, Kubo T, Kikuchi T, Sato N, Hasegawa T, Kiyonari H, Mukumoto Y, Takano KI, Himi T, Ichimiya S. (2017) Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. J Pathol. doi: 10.1002/path.4951.
CDB0844K Triobp5 LacZ KI Shin-ichiro Kitajiri Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI. (2019) TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing. JCI Insight. 4(12). pii: 128561.
CDB0850K

(RBRC11335)

Ppp6c conditional Hiroshi Shima Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H. (2015) Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene. 34(35): 4647-55.
CDB0853K Prmt1 conditional Junichiro Mizuguchi Hata K, Yanase N, Sudo K, Kiyonari H, Mukumoto Y, Mizuguchi J, Yokosuka T. (2016) Differential regulation of T-cell dependent and T-cell independent antibody responses through arginine methyltransferase PRMT1 in vivo. FEBS Lett. 590(8):1200-10. doi: 10.1002/1873-3468.12161.
CDB0862K MUK (DLK/Map3k12) KI(ires-β geo) Shu-ichi Hirai Hirai, S., Cui, DF., Miyata, T., Ogawa M., Kiyonari, H., Suda, Y., Aizawa, S., Banba, Y. and Ohno, S. (2006). The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex. The Journal of Neuroscience 26, 11992-12002.
CDB0877K GATA1IRESMCM IRES Mer-Cre-Mer KI Yosuke Tanaka Tanaka Y, Sanchez V, Takata N, Yokomizo T, Yamanaka Y, Kataoka H, Hoppe PS, Schroeder T, Nishikawa SI. (2014) Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts. Cell Rep. 8(1): 31-39.
CDB0884K

(RBRC11338)

Arf4(loxP) conditional Furuichi Teiichi Nobutake Hosoi, Koji Shibasaki, Mayu Hosono, Ayumu Konno, Yo Shinoda, Hiroshi Kiyonari, Kenichi Inoue, Shin-ichi Muramatsu, Yasuki Ishizaki, Hirokazu Hirai, Teiichi Furuichi and Tetsushi Sadakata. (2019) Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments. Journal of Neuroscience 39(32):6339-6353.
CDB0885K

(RBRC11339)

Arf5(loxP) conditional
CDB0895K TSK(loxP) conditional Kunimasa Ohta Ito, N., Riyadh, M. A., Ahmad, S. A. I., Hattori, S., Kanemura, Y., Kiyonari, H., Abe, T., Furuta, Y., Shinmyo, Y., Kaneko, N., Hirota, Y., Lupo, G., Hatakeyama, J., Abdulhaleem, M. F., Anam, M. B., Yamaguchi, M., Takeo, T., Takebayashi, H., Takebayashi, M., Oike, Y., Nakagata, N., Shimamura, K., Holtzman, M. J., Takahashi, Y., Guillemot, F., Miyakawa, T., Sawamoto, K., & Ohta, K. (2021). Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Sci Transl Med, 13(587).
CDB0907K sema7a(loxP) conditional KO (loxP) Hitoshi Sakano Inoue, N., Nishizumi, H., Naritsuka, H., Kiyonari, H., Sakano, H. (2018) Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation. Nat. Commun. Nature 9, 1842
CDB0908K Plxnc1(loxP):plexinC1 conditional KO (loxP) Hitoshi Sakano Inoue, N., Nishizumi, H., Naritsuka, H., Kiyonari, H., Sakano, H. (2018) Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation. Nat. Commun. Nature 9, 1842
CDB0910K ROSA-Etv2 CAG-floxSTOP-Etv2-frtGFP Hiroshi Kataoka Hayashi M, Pluchinotta M, Momiyama A, Tanaka Y, Nishikawa S, Kataoka H. Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp Hematol. 2012 Sep;40(9):738-750.
CDB0913K Gm129 Conditional KO flox Toru Takumi Goriki, A., Hatanaka, F., Myung, J., Kim, JK., Yoritaka, T., Tanoue, S., Abe, T., Kiyonari, H., Fujimoto, K., Kato, Y., Todo, T., Matsubara, A., Forger, D. and Takumi, T. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12(4):e1001839. doi: 10.1371/journal.pbio.1001839.
CDB0916K CNOT1 KO(simple knockout), conditional KO Toru Suzuki
Tadashi Yamamoto
Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, Yasuhide Furuta, Keiji Kuba, and Tadashi Yamamoto. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. (2020) Life Science Alliance, in press.
CDB0923K Prdm1(EGFP) GFP KI Mitinori Saitou Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M. (2015) Quantitative Dynamics of Chromatin Remodeling during Germ Cell pecification from Mouse Embryonic Stem Cells. Cell Stem Cell. 16(5):517-32.
CDB0927K Fhod3(loxP) conditional Ryu Takeya Ushijima T, Fujimoto N, Matsuyama S, Kan-O M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H. (2018) The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. J Biol Chem. 293(1):148-162.
CDB0933K RhoJ-flox Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, Uemura A, Koh GY. (2014) Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 25(1): 102-117.
CDB0938K Lats1 KO(simple knock-out) Norikazu Yabuta Mukai, S., Yabuta, N., Yoshida, K., Okamoto, A., Miura, D., Furuta, Y., Abe, T. and Nojima H. (2015) Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B. Sci Rep 5:16173. doi: 10.1038/srep16173.
CDB0939K Ptger2(loxP) Shuh Narumiya Aoki T, Frȍsen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J, Narumiya S. (2017) Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal. 10(465). pii: eaah6037. doi: 10.1126/scisignal.aah6037
CDB0941K AS3_9(-) KO(simple knock-out) Norihiro Okada Nishihara H, Kobayashi N, Kimura-Yoshida C, Yan K, Bormuth O, Ding Q, Nakanishi A, Sasaki T, Hirakawa M, Sumiyama K, Furuta Y, Tarabykin V, Matsuo I, Okada N. (2016) Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet. 12(10):e1006380.
CDB0944K Psmd10(loxP) conditional Masatoshi Kudo Sakurai T, Higashitsuji H, Kashida H, Watanabe T, Komeda Y, Nagai T, Hagiwara S, Kitano M, Nishida N, Abe T, Kiyonari H, Itoh K, Fujita J, Kudo M. (2017) The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3. Oncotarget. 8(15):24762-24776.
CDB0945K Cldn-7(loxP) Sachiko Tsukita Tanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A. and Tsukita, S. (2015) Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice. Gut 64(10): 1529-38.
CDB0949K Optn(-):optineurin KO Hideshi Kawakami Kurashige, T., Kuramochi, M., Ohsawa, R., Yamashita, Y., Shioi, G., Morino, H., Kamada, M., Ayaki, T., Ito, H., Sotomaru, Y., Maruyama, H., & Kawakami, H. (2021). Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. Neurobiol Dis, 148, 105215.
CDB0952K Evi3(-) Masaki Yasukawa Ohkubo, N., Matsubara, E., Yamanouchi, J., Akazawa, R., Aoto, M., Suzuki, Y., Sakai, I., Abe, T., Kiyonari, H., Matsuda, S., Yasukawa, M. and Mitsuda, N. (2014) Abnormal behaviors and developmental disorder of hippocampus in zinc finger protein 521 (ZFP521) mutant mice. PLoS One 9(3): e92848.
CDB0956K Faf2 UBXD8 (loxP), conditional KO Toyoshi Fujimoto Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. (2015). Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One. 10(5):e0127114.
CDB0960K KIAA1462 KO(simple knock-out) Mikio Furuse Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI. (2017) Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 37(9):1667-1673.
CDB0977K LPAR6 conditional KO (loxP) Satoshi Ishii Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M. (2016) Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int Immunol. 28(6):283-92.
CDB0982K exophilin5(Exph5) KO Tetsuro Izumi Okunishi, K., Wang, H., Suzukawa, M., Ishizaki, R., Kobayashi, E., Kihara, M., Abe, T., Miyazaki, J. I., Horie, M., Saito, A., Saito, H., Nakae, S., & Izumi, T. (2020). Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. J Clin Invest, 130(7), 3919-3935.
CDB0983K

(RBRC09351)

Rad21L(-):Gm14160 KO(simple knock-out) Yoshinori Watanabe Ishiguro KI, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y. (2014) Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 28(6): 594-607.
CDB0985K Prdm14(-) Mitinori Saitou Yamaji M, Seki Y, Kurimoto K, Yabuta Y, Yuasa M, Shigeta M, Yamanaka K, Ohinata Y, Saitou M. (2008) Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet. 40(8): 1016-1022.
CDB0998K gpr143 Yoshio Goshima Fukuda, N., Naito, S., Masukawa, D., Kaneda, M., Miyamoto, H., Abe, T., Yamashita, Y., Endo, I., Nakamura, F. and Goshima, Y. (2015) Expression of ocular albinism 1 (OA1), 3, 4- dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal organs. Brain Res 1602: 62-74
CDB1000K cldn14 KO(simple knock-out) Takahiro Kubota Shiraiwa Y, Daikoku E, Saito M, Yamashita Y, Abe T, Ono F, Kubota T. (2017) Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice. Auris Nasus Larynx. pii: S0385-8146(17)30052-4.
CDB1008K tau-YFP Olfr1019 Venus KO/KI Hitoshi Sakano Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. (2017) Immobility responses are induced by photoactivation of single glomerular species esponsive to fox odour TMT. Nat Commun. 8:16011. doi: 10.1038/ncomms16011.
CDB1012K IL31RA(lacZ) KI(lacZ KI) Saburo Saito Saito S, Aoki A, Arai I, Takaishi S, Ito H, Akiyama N, Kiyonari H. (2017) Regulation of Th2 responses by different cell types expressing the interleukin‑31 receptor. Allergy, Asthma & Clinical Immunology. DOI 10.1186/s13223-017-0194-9
CDB1016K Pin1 conditional Tomoichiro Asano Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T. (2015) Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit. J Biol Chem. 290(40):24255-66.
CDB1019K Nrd1(loxP) conditional Eiichiro Nishi Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E. (2016) Nardilysin Is Required for Maintaining Pancreatic β-Cell Function. Diabetes. 65(10):3015-27.
CDB1022K SASPase/ASPRV1 KI Takeshi Matsui Matsui, T., Kadono-Maekubo, N., Suzuki, Y., Furuichi, Y., Shiraga, K., Sasaki, H., Ishida, A., Takahashi, S., Okada, T., Toyooka, K., Sharif, J., Abe, T., Kiyonari, H., Tominaga, M., Miyawaki, A., & Amagai, M. (2021). A unique mode of keratinocyte death requires intracellular acidification. Proc Natl Acad Sci U S A, 118 (17) e2020722118
CDB1024K Sema6A conditional KO (loxP) Takahiko Kawasaki Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata. (2019) Semaphorin 6A–Plexin A2/A4 interactions with radial glia regulate migration termination of superficial layer cortical neurons. iScience. 21:359-374.
CDB1026K Tgf conditional Tomoichiro Asano Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T. (2017) Trk-fused gene(TFG) regulates pancreatic β cell mass and insulin secretory activity. Sci Rep. 7(1):13026. doi: 10.1038/s41598-017-13432-x.
CDB1027K Arf1(loxP) conditional Toshio Watanabe Sumiyoshi, M., Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda (2021). Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J Immunol 206(2): 366-375.
CDB1028K IRF3 conditional Tadatsugu Taniguchi Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T. (2018) Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A. 115(20):5253-5258.
CDB1030K Ccl21a(Tomato) tdTomato KI Yousuke Takahama Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.(2017) Essential role of CCL21 in establishment of central selftolerance in T cells. J Exp Med. 214(7):1925-1935.
CDB1032K ヒトCaSR activation mutation C129S(t757a) Casr(hCasr c129s) KI Toshio Matsumoto Dong, B., Endo, I., Ohnishi, Y., Kondo, T., Hasegawa, T., Amizuka, N., Kiyonari, H., Shioi, G., Abe, M., Fukumoto, S. and Matsumoto, T. (2015) Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH). J Bone Miner Res. 2015 May 12. doi: 10.1002/jbmr.2551.
CDB1033K AF10 conditional KO, Mllt10, exon 16 floxed, loxP (phage P1 loxP) Issay Kitabayashi Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D.(2017). Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep. 2017 Sep 20;7(1):11922
CDB1054K ヒトCaSR activation mutation A843E(c2900a) Casr(hCasr A843E) KI Toshio Matsumoto Dong, B., Endo, I., Ohnishi, Y., Kondo, T., Hasegawa, T., Amizuka, N., Kiyonari, H., Shioi, G., Abe, M., Fukumoto, S. and Matsumoto, T. (2015) Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH). J Bone Miner Res. 2015 May 12. doi: 10.1002/jbmr.2551.
CDB1060K Period2 Base substitutions Okamura Hitoshi Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, Okamura H. (2019) Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity. Nat Commun. 10(1):2563.
CDB1061K Camsap1 KO Masatoshi Takeichi
Wenxiang Meng
Zhou, Z., Xu, H., Li, Y., Yang, M., Zhang, R., Shiraishi, A., Kiyonari, H., Liang, X., Huang, X., Wang, Y., et al. (2020). CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity. Proc Natl Acad Sci U S A 117, 22193-22203.
CDB1062K Camsap2:Camsap1|1 KO(simple knock-out) Masatoshi Takeichi Varisa Pongrakhananon, Hiroko Saito, Sylvain Hiver, Takaya Abe, Go Shioi, Wenxiang Meng, and Masatoshi Takeichi. (2018) CAMSAP3 maintains neuronal polarity through regulation of microtubule stability. PNAS 115: 9750-9755
CDB1070K early Bcell factor 3 conditional KO Atsuko Sehara Kuriki, M., Sato, F., Arai, H.N., Sogabe, M., Kaneko, M., Kiyonari, H., Kawakami, K., Yoshimoto, Y., Shukunami, C., and Sehara-Fujisawa, A. (2020). Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development 147.
CDB1078K Cd47(loxP) conditional KO Takashi Matozaki Saito, Y., Respatika, D., Komori, S., Washio, K., Nishimura, T., Kotani, T., Murata, Y., Okazawa, H., Ohnishi, H., Kaneko, Y., Yui, K., Yasutomo, K., Nishigori, C., Nojima, Y., Matozaki, T. (2017). SIRPα(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. Proc Natl Acad Sci USA 114, 201711345–E10160.
CDB1079K

(RBRC09342)

Kif14 KO(simple knock-out) Toshiaki Sakisaka Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T. (2013) Kif14 mutation causes severe brain malformation and hypomyelination. PLoS One. 8(1):e53490. doi:10.1371/journal.pone.0053490.
CDB1091K CAPS1(CADPS) Yukio Kawahara Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y. (2016) CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Reports 17(8): 2004-2014.
CDB1100K Myrip(-) Tetsuro Izumi Fan F, Matsunaga K, Wang H, Ishizaki R, Kobayashi E, Kiyonari H, Mukumoto Y, Okunishi K, Izumi T. (2017) Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. Elife. 6. pii: e26174. doi: 10.7554/eLife.26174. PubMed PMID: 28673385; PubMed Central PMCID: PMC5496739.
CDB1102K Fam132a(-) KO(simple knock-out) Noriyuki Ouchi Ogawa H, Ohashi K, Ito M, Shibata R, Kanemura N, Yuasa D, Kambara T, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Otaka N, Kawanishi H, Yamaguchi S, Enomoto T, Abe T, Kaneko M, Takefuji M, Murohara T, Ouchi N.(2019)Adipolin/CTRP12 protects against pathological vascular remodeling through suppression of smooth muscle cell growth and macrophage inflammatory response. Cardiovascular Research, pii: cvz074.
CDB1107K Mir335(-) KO(simple knock-out) Atsuko Sehara Hiramuki Y, Sato Y, Furuta Y, Surani M. A, Sehara-Fujisawa A. (2015). Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration. PLoS ONE 10(6): e0130436.
CDB1127K Ptprz(Pro1998end):Ptprz(PTP-D1 stop変異) conditional KO (loxP) Masaharu Noda Tanga N, Kuboyama K, Kishimoto A, Kihara M, Kiyonari H, Watanabe T, Fujikawa A, Noda M. (2019) Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ). PLoS One. 14(6):e0217880.
CDB1144K Gpsm2(loxP):modified LGN-venusC KO Fumio Matsuzaki Fujita I, Shitamukai A, Kusumoto F, Suetsugu T, Mase S, Omori A, Kato K, Abe T, Shioi G, Konno D, Matsuzaki F. (2020) Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development. Nat. Cell Biol. 22, 26-37.
CDB1170K Klotho conditional Kazushige Sakaguchi Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro-O M, Furuta Y, Sakaguchi K. (2017) Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 7:40534. doi:10.1038/srep40534.
CDB1182K HchwR-Venus Olfr1019 ires-ChRWR-Venus KI Hitoshi Sakano Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. (2017) Immobility responses are induced by photoactivation of single glomerular species esponsive to fox odour TMT. Nat Commun. 8:16011. doi: 10.1038/ncomms16011.
CDB1185K miR-199a-2 KO(simple knock-out) Kinichi Nakashima Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M., Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. and Nakashima, K. (2015) miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes. Cell Rep 12(11): 1887-901.
CDB1190K FGFR4 conditional Kazushige Sakaguchi Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro-O M, Furuta Y, Sakaguchi K. (2017) Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 7:40534. doi:10.1038/srep40534.
CDB1193K R26R(H2B-FLAG) ROSA26(H2B-FLAG)KI Shinichi Nakagawa Mito M, Kadota M, Tanaka K, Furuta Y, Abe K, Iwasaki S, Nakagawa S. (2018) Cell Type-Specific Survey of Epigenetic Modifications by Tandem Chromatin Immunoprecipitation Sequencing. Sci Rep. 8(1):1143.
CDB1201K R26-STOP-SHARPIN ROSA26 conditional KI Iwai Kazuhiro, Katsuhiro Sasaki Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K. (2019) Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 10(1):3878.
CDB1212K Ndc80 KO Tomoya Kitajima Yoshida, S., S. Nishiyama, L. Lister, S. Hashimoto, T. Mishina, A. Courtois, H. Kyogoku, T. Abe, A. Shiraishi, M. Choudhary, Y. Nakaoka, M. Herbert and T. S. Kitajima (2020). "Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes." Nat Commun 11(1): 2652.
CDB1218K Haus6 conditional Gohta Goshima
Sadanori Watanabe
Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Cell Rep. 15(1):54-60.
CDB1228K Adam19(loxP,P2A Venus) conditional KO (loxP) Atsuko Sehara Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A. (2019) Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 29(3):603-616
CDB1232K nphp3 point mutations Takahiko Yokoyama Nakajima Y, Kiyonari H, Mukumoto Y, Yokoyama T. (2018) The Inv compartment of renal cilia is an intraciliary signal activating center to phosphorylate ANKS6. Kidney Int. pii: S0085-2538(17)30852-9.
CDB1237K 1110012J17Rik conditional Atsushi Suzuki Satake T, Yamashita K, Hayashi K, Miyatake S, Tamura-Nakano M, Doi H, Furuta Y, Shioi G, Miura E, Takeo YH, Yoshida K, Yahikozawa H, Matsumoto N, Yuzaki M, Suzuki A. (2017) MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. EMBO J. pii: e201695630. doi: 10.15252/embj.201695630.
CDB1255K beta5t(G49S-pA) SNP KI Yousuke Takahama Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y. (2017) A human SMB11 variant affects thymoproteasome processing and CD8+ T cell production. JCI Insight. 2(10). pii: 93664. doi:10.1172/jci.insight.93664.
CDB1256K Fam59b(loxP): (GI: 268832228) conditional KO (loxP) Hiroaki Konishi Nishino T, Tamada K, Maeda A, Abe T, Kiyonari H, Funahashi Y, Kaibuchi K, Takumi T, Konishi H. (2019) Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Mol Brain. 12(1):94.
CDB1301K Rnu11(loxP):U11 spliceosomal RNA(Rnu11) conditional KO (loxP) Tadatsugu Taniguchi Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T. (2019) Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23653-23661.
CDB1302K Hey1 conditional Osamu Nakagawa Watanabe, Y., D. Seya, D. Ihara, S. Ishii, T. Uemoto, A. Kubo, Y. Arai, Y. Isomoto, A. Nakano, T. Abe, M. Shigeta, T. Kawamura, Y. Saito, T. Ogura and O. Nakagawa (2020). "Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription." J Biol Chem 295(51): 17632-17645.
CDB1303K Dmrta1-KO(CRISPR) KO(CRISPR) Fumio Matsuzaki Daijiro Konno, Chiaki Kishida, Kazumitsu Maehara, Yasuyuki Ohkawa, Hiroshi Kiyonari, Seiji Okada, Fumio Matsuzaki. (2019) Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes. Development. 146(15). pii: dev174243.
CDB1320K ROSA26-STOP-Myd88_L252P-ires-eGFP-pA conditional Tg Kazuhiro Iwai Jo, T., M. Nishikori, Y. Kogure, H. Arima, K. Sasaki, Y. Sasaki, T. Nakagawa, F. Iwai, S. Momose, A. Shiraishi, H. Kiyonari, N. Kagaya, T. Onuki, K. Shin-Ya, M. Yoshida, K. Kataoka, S. Ogawa, K. Iwai and A. Takaori-Kondo (2020). LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells. Blood 136(6): 684-697.
CDB1353K DCTN1 point mutation Tsuboi Yoshio Deshimaru, M., T. Mishima, T. Watanabe, K. Kubota, M. Hosoi, M. Kinoshita-Kawada, J. Yuasa-Kawada, M. Ikeda, M. Mori, Y. Murata, T. Abe, M. Enjoji, H. Kiyonari, S. Kodama, S. Fujioka, K. Iwasaki and Y. Tsuboi (2021). "Behavioral profile in a Dctn1(G71A) knock-in mouse model of Perry disease." Neurosci Lett 764: 136234.
CDB1355K HAUS6 KO Gohta Goshima Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Cell Rep. 15(1):54-60.
CDB1373K Nppb KI Ryuji Okamoto Okamoto R, Hashizume R, Suzuki N, Ito R, Tokuhara T, Fujiwara H, Ye Z, Ito H, Abe T, Dohi K. (2022) Serum-Inducted Expression of Brain Natriuretic Peptide Contributes to Its Increase in Patients with HFpEF. Int J Mol Sci. 23(6),2991.
RandomTransgenesis

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CDB Acc.No. Line Name Corresponding Researcher Original paper Reference Remarks from researchers
CDB0001T K1-1 Shinichi Aizawa Kurokawa D, Takasaki N, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development 131, 3307ー3317. 2004 A transgenic line. Transgene: Otx2 BAC DNA encompassing -170kb to -30kb is conjugated with Otx2 -1.8kb 5' region adjacent to the translation start site and LacZ-pA (BAC#1, Fig.1 in original paper).
CDB0003T K44(K43-49) Shinichi Aizawa Kurokawa D, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. (2004) A transgenic line. Transgene: LacZ-pA is inserted at the translational start site of Otx2 BAC DNA encompassing -50kb to +120kb.(Fig. 5Ba in original paper)
CDB0005T K27 Shinichi Aizawa Kurokawa D, Takasaki N, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development 131, 3307ー3317. 2004 A transgenic line. Transgene: Otx2 AN enhancer that directs the expression in anterior neuroectodermOtx2 AN enhancer (15 kb XhoI fragment at -92kb to -77kb) that directs the expression in anterior neuroectoderm (Fig2Ba-f in original paper)
CDB0022T K170 Shinichi Aizawa Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 A transgenic line. Transgene: Skate Otx2 AN enhancer that directs the expression in anterior neuroectoderm (Fig. 5A,B in Original paper )
CDB0023T K177 Shinichi Aizawa Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 A transgenic line. Transgene: Skate Otx2 FM enhancer that directs the expression in forebrain and midbrain (Fig. 5C, D in original paper)
CDB0024T K178 Shinichi Aizawa Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 A transgenic line. Transgene: Coelacanth Otx2 AN enhancer that directs the expression in anterior neuroectoderm (Fig. 5E,F in Original paper )
CDB0025T K179 Shinichi Aizawa Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 A transgenic line. Transgene: Coelacanth Otx2 FM enhancer that directs the expression in forebrain and midbrain (Fig. 5G,H in Original paper )
CDB0027T K33 Shinichi Aizawa Kurokawa D,Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. 2004 A transgenic line. Transgene: Otx2 FM enhancer (10 kb XhoI-ClaI fragment at the -77kb to -68kb) that directs the expression in forebrain and midbrain (Fig. 1Ba-f in original paper)
CDB0033T K43 Shinichi Aizawa Kurokawa D,Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. 2005 A transgenic line. Transgene: Otx2 FM2 enhancer (10 kb MluI-NotI fragment at +106kb to +116kb 3’ downstream) that directs the expression in forebrain and midbrain (Fig. 4Bd-i in original paper)
CDB0034T 1.8Otx2-H2B-mCherry Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0035T Cer1-H2BmCherry Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0036T Lefty1-H2BmCherry Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0037T 1.8Otx2-CreERTM Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0038T Dkk1-CreERTM Shinichi Aizawa Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91.
CDB0201T-1 pCAGGS-kik-1 Shinichi Aizawa Kurotaki, Y., Hatta, K., Nakao, K., Nebeshima, Y., and Fujimori, T. Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science 316(5825):719-723(2007)" Expression level is higher than CAG-KikGR-2
CDB0201T-2 pCAGGS-kik-2 Shinichi Aizawa Kurotaki Y, Hatta K, Nakao K, Nabeshima Y, Fujimori T. Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science. 2007 May 4;316(5825):719-23. Expression level is lower than CAG-KikGR-1
CDB0404T CAG-MerCreMer Shin-Ichi Nishikawa Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S. (2009) Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 129(10): 2386-2395.
CDB0406T TBP-2 Junji Yodoi Okuyama H, Yoshida T, Son A, Oka S, Wang D, Nakayama R, Masutani H, Nakamura H, Nabeshima Y, Yodoi J. Thioredoxin binding protein 2 modulates natural killer T cell-dependent innate immunity in the liver: possible link to lipid metabolism. Antioxid Redox Signal. 11(10):2585-93. 2009 Line C was analyzed.
CDB0407T stella-EGFP Mitinori Saitou Payer, B., Chuva de Sousa Lopes, S. M., Barton, S. C., Lee, C., Saitou, M., and Surani, M. A. (2006). Generation of stella-GFP transgenic mice, a novel tool to study germ cell development. Genesis, 44, 75-83. Seki, Y., Yamaji, M., Yabuta, Y., Sano, M., Shigeta, M., Matsui, Y., Saga, Y., Tachibana, M., Shinkai, Y., and Saitou, M. (2007). Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development, 134, 2627-2638." EGFP is expressd under the control of stella regulatory elements. The original stella-EGFP BAC is generated in the lab of Prof. M. Azim Surani.
CDB0409T Dct Hes1 Shin-Ichi Nishikawa Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa SI. (2006) Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173, 333-339. A line that expresses HES1 under Dct promotor that is specific to melanocyte. It can be used for constitutively activating Notch signal in malnocyte lineage.
CDB0410T Dct Hes 1 dn Shin-Ichi Nishikawa Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa SI. (2006) Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173, 333-339. A line that expresses dominant negative form of HES1 under Dct promoter that is specific to melanocyte. It is used for constitutively inhibiting Notch signal in melanocyte lineage.
CDB0413T Blimp1-mEGFP Michinori Saitou Ohinata, Y., Payer, B., O’Carroll, D., Ancelin, K., Ono, Y., Sano, M., Barton, S. C., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., *Saitou, M., and *Surani, M. A. (2005). Blimp1 is a critical determinant of the germ cell lineage in mice. Nature, 436, 207-213. membrane-targeted EGFP is expressed under the control of Blimp1
CDB0415T-34

(RBRC02592, 09237)

p21-p-luc Eiji Hara Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., David J. Mann, Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K., and Hara, E. Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals. Proc. Natl. Acad. Sci. USA. 104/38, 15034-15039, 2007 fire fly luciferase is expressed under the control of the p21 gene promoter
CDB0416T-53

(RBRC05271, 09236)

p16-luc Eiji Hara Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N. & Hara, E. Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53. J. Cell Biol. 186: 393-407 (2009)" Firefly luciferase is expressed under the control of the human p16INK4a gene promoter.
CDB0419T-2 CAG-CAT-PGrn Shin-ichi Osada Kato M, Hasunuma N, Manabe M, Nakayama R, Takeda J, Itami S, Taira M, Osada S-I., Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth.:Journal of Dermatological Science.53, 222-243, 2009. Human progranulin can be expressed in a tissue-specific manner, when cross-bred with a conditional Cre transgenic mouse
CDB0425T misCreERTM Shin-ichi Abe JiDong Zhang, Ko Eto, Asuka Honmyou, Kazuki Nakao, Hiroshi Kiyonari, and Shin-ichi Abe. Neuregulins are essential in spermatogonial proliferation and meiosis initiation in neonatal mouse testis. DEVELOPMENT 2011 in press. Cre expression is induced by administration of tamoxifen in Sertoli cells driven by MIS promoter
CDB0437T PLCD1 Kiyoko Fukami Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K.Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun. 2012 Jul 17;3:963. doi: 10.1038/ncomms1960. PLCD1 is expressed under control of FOXN1 promoter.
CDB0446T aP2-Fcor Masato Kasuga Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S-I, Itoh H. Novel repressor regulates insulin sensitivity through interaction with Foxo1.: The EMBO JOURNAL. online publication 17 April 2012. Fcor is expressed in white adipose tissue and brown adipose tissue.
CDB0447T

(RBRC05278)

HB-EGFm Masato Kasuga Fukatsu T, Noguchi T, Hossoka T, Ogura T, Kotani K, Abe T, Shibakusa T, Inoue K, Sakai M, Tobimatsu K, Inagaki K, Yoshioka T, Matsuo M, Nakae J, Matsuki Y, Hiramatsu R, Kaku K, Okamura H, Fushiki T, Kasuga M. Muscle-Specific Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Increases Peripheral Glucose Disposal and Insulin Sensitivity. Endcrinology. 150(6), 2683-2691(2009).
CDB0449T

(RBRC05279)

I7(RDY)-ires-Nrp1-ires-gap-ECFP:IANC Hitoshi Sakano Imai, T., Yamazaki, T., Kobayakawa, R., Abe, T., Suzuki, M., and Sakano, H. (2009) Pre-target axon sorting establishes the neural map topography. Science, 325(5940), 585-590. "A mutant-type odorant receptor, I7(D126R/R127D), Neuropilin-1, and an axonal marker gene, gap-ECFP, are expressed under MOR23 (Olfr16) gene promoter. I7(D126R/R127D) mutant is defective in G protein coupling. Control strains are RBRC02931 and RBRC02933 (deposited to RIKEN BRC)."
CDB0450T

(RBRC03510)

aP2/Δ256Foxo1 Masato Kasuga Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K., Lombes, M. and Hayashi, Y. Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure. DIABETES: 57, 563-576, 2008. A transactivation-defective Foxo1 (D256Foxo1) is expressed in adipose tissue
CDB0452T Ednrb-KikGR Hideki Enomoto Nishiyama C, Uesaka T, Manabe T, Yonekura Y, Nagasawa T, Newgreen DF, Young, HM, Enomoto H. (2012) Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system. Nat Neurosci. 15(9):1211-8. KikumeGR is expressed under the promoter/enhancer region of the Ednrb gene.
CDB0453T pCAG-mito-Venus #25 Anthony C.F. Perry Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E. and Perry, A.C.F. (2006). Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. EMBO J. 25, 834-845. Express Venus in mitochondria
CDB0454T pCAG-Plcz-IRES-Venus CS44 Anthony C.F. Perry Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. Express phospholipase C ubiquitously
CDB0455T pCAG-Plcs-ct-Venus CV11 Anthony C.F. Perry Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. Express phospholipase C ubiquitously
CDB0456T pCAG-Plcz-IRES-Venus CS42 Anthony C.F. Perry Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. Express phospholipase C ubiquitously
CDB0457T pCAG-Plcz-IRES-Venus CS45 Anthony C.F. Perry Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. Express phospholipase C ubiquitously
CDB0458T pCAG-mito-Venus #19 Anthony C.F. Perry Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E. and Perry, A.C.F. (2006). Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. EMBO J. 25, 834-845. Express Venus in mitochondria
CDB0460T

(RBRC05383)

Prdm1(Blimp1)-mVenus Mitinori Saitou Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. Venus targetted to plasma membrane is expressd under the control of Blimp1 regulatory elements
CDB0461T Prdm14-mVenus Mitinori Saitou Yamaji, M., Seki, Y., Kurimoto, K., Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka, K., Ohinata, Y., and Saitou, M. (2008). Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nature Genetics, 40, 1016-1022. Venus targetted to plasma membrane is expressd under the control of Prdm14 regulatory elements
CDB0462T stella-Venus Mitinori Saitou Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. Venus is expressd under the control of stella regulatory elements
CDB0463T nanos3-EGFP Mitinori Saitou Yamaji, M., Tanaka, T., Shigeta, M., Chuma, S., Saga, Y., and Saitou, M. (2010). Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3. Reproduction, 139, 381-393. nanos3-EGFP fusion protein (functional) is expressed under the control of nanos3 regulatory elements
CDB0464T Prdm1(Blimp1)-mKikGR Mitinori Saitou Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. (2009). A signaling principle for the specification of the germ cell lineage in mice. Cell, 137, 571-584. KikGR targetted to plasma membrane is expressd under the control of Blimp1 regulatory elements
CDB0465T stella-ECFP Mitinori Saitou Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. CFP is expressd under the control of stella regulatory elements
CDB0467T Kd-B6 Ryotaro Yoshida Yoshihiro Inoue, Junko Tashiro-Yamaji, Michihiro Hayashi, Hiroshi Kiyonari,Tetsunosuke Shimizu, Minenori Ibata, Hidenori Yamana, Takahiro Kubota, Nobuhiko Tanigawa and Ryotaro Yoshida. Transgene number-dependent, gene expression rate-independent rejection of Dd-, Kd-, or DdKd-transgened mouse skin or tumor cells from C57BL/6 (DbKb) mice.:Microbiology and Immunology. 55, 446-453, 2011. Cosmid (for Dd) or cDNA (for Kd) is derived from BALB/c mice or BALB/c T-cell line.
CDB0468T Dd-B6 Ryotaro Yoshida Yoshihiro Inoue, Junko Tashiro-Yamaji, Michihiro Hayashi, Hiroshi Kiyonari,Tetsunosuke Shimizu, Minenori Ibata, Hidenori Yamana, Takahiro Kubota, Nobuhiko Tanigawa and Ryotaro Yoshida. Transgene number-dependent, gene expression rate-independent rejection of Dd-, Kd-, or DdKd-transgened mouse skin or tumor cells from C57BL/6 (DbKb) mice.:Microbiology and Immunology. 55, 446-453, 2011. Cosmid (for Dd) or cDNA (for Kd) is derived from BALB/c mice or BALB/c T-cell line.
CDB0476T pCAGGS-Kif14 Toshiaki Sakisaka Kohei Fujikura, Tomiyoshi Setsu, Kenji Tanigaki, Takaya Abe, Hiroshi Kiyonari, Toshio Terashima, Toshiaki Sakisaka., Kif14 Mutation Causes Severe Brain Malformation and Hypomyelination.(2013) PLoS ONE 8(1): e53490. doi:10.1371/journal.pone.0053490. Kif14 is expressed ubiquitously.
CDB0479T CaMKⅡa-E4BP4 Kamon Sanada Tamai S, Imaizumi K, Kurabayashi N, Nguyen MD, Abe T, Inoue M, Fukada Y Sanada K. (2014) Neuroprotective role of the basic leucine zipper transcription factor NFIL3 in models of amyotrophic lateral sclerosis. J Biol Chem. 289(3): 1629-1638. "CaMKIIa-E4BP4-1:E4BP4 is expressed under the control of CaMKIIa promoter CaMKIIa-E4BP4-2:E4BP4 is expressed under the control of CaMKIIa promoter"
CDB0480T aP2-hGpr43/Ffar2 Ikuo Kimura Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013;4:1829. human Gpr43/Ffar2 is expressed in adipose tissues by aP2 promoter
CDB0481T Aid-cre cd2 Tasuku Honjo Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. Cre and human CD2 are expressed about 35% of germinal center B cells from an Aicda reporter transgene.
CDB0482T dCEBP-ac-cre Tasuku Honjo Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. The mouse carries an inactivated Aicda transgene due to the deletion of CEB/P binding site in the region 4 enhancer.
CDB0483T dR4-ac-cre Tasuku Honjo Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. The mouse carries an inactivated Aicda transgene due to the deletion of the region 4 enhancer.
CDB0484T dR2-ac-cre Tasuku Honjo Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. The mouse carries an inactivated Aicda transgene due to the deletion of the region 2 enhancer.
CDB0485T γ2pepV Tomoo Hirano Tanaka S, Kawaguchi S, Shioi S, Hirano T. Long-term Potentiation of Inhibitory Synaptic Transmission onto Cerebellar Purkinje Neurons Contributes to Adaptation of Vestibulo-Ocular Reflex. The Journal of Neuroscience. 2013; 33(43):17209-17220. γ2 peptide which blocks binding of GABA(A) receptor γ2 subunit and GABARAP is selectively expressed in cerebellar Purkinje neurons.
CDB0486T mVenus-p27K Toshio Kitamura Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T. (2014) A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012. doi: 10.1038/srep04012 A G0 marker is expressed by CAG promoter; expression is strong in muscle cells
CDB0489T #123-Fez-lgVpA Masahiko Hibi Hirata, T. Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons reguolates development of the olfactory bulb non-cell-autonomously. Development 133, 1433-1443. Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, Yoshihara Y. Goofy coordinates the acuity of olfactory signaling. J Neurosci. 2013 Aug 7;33(32):12987-12996. The transgenic mice express Fezf1 in olfactory and vomeronasal sensory neurons under the control of Goofy promoter
CDB0490T Neurog2-d4Venus Takaki Miyata Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T. (2014) Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Dev Growth Differ. 56(4):293-304. doi:10.1111/dgd.12131. d4Venus is expressed under the control of Neurog2 enhancer/promoter
CDB0491T Gadd45g-d4venus Takaki Miyata Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T. (2014) Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Dev Growth Differ. 56(4):293-304. doi:10.1111/dgd.12131. d4Venus is expressed under the control of Gadd45g enhancer/promoter
CDB0503T Gpnmb Jun Wada Katayama, A., Nakatsuka, A., Eguchi, J., Murakami, K., Teshigawara, S., Kanzaki, M., Nunoue, T., Hida, K., Wada, N., Yasunaka, T., Ikeda, F., Takaki, A., Yamamoto, K., Kiyonari, H., Makino, H. and Wada, J. (2015) Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis. Sci Rep. 5:16920. doi:10.1038/srep16920. Gpnmb is expressed in macrophages and adipocytes.
CDB0512T Neurog2CreER(G2A) Tatsumi Hirata Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019. Neuronal birthdate tag driver designed for TM administration to induce recombination of loxP sequences in a neuronal birthdate-dependent manner
CDB0516T inducible cardiospecific mutant TG of LTCC beta2a subunit Hiroyuki Nakayama Tonegawa K, Otsuka W, Kumagai S, Matsunami S, Hayamizu N, Tanaka S, Moriwaki K, Obana M, Maeda M, Asahi M, Kiyonari H, Fujio Y, Nakayama H. (2017) Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 312(3):H501-H514. non-phosphorylatable mutant of LTCC beta2a subunit is expressed by the regulation of modified alpha-MHC promoter
CDB0517T Emu/miR142 Hideki Nakakuma Kuriyama K, Enomoto Y, Suzuki R, Watanuki J, Hosoi H, Yamashita Y, Murata S, Mushino T, Tamura S, Hanaoka N, Dyer M, Siebert R, Kiyonari H, Nakakuma H, Kitamura T, Sonoki T. (2017) Enforced expression of MIR142, a target of chromosome translocation in human B-cell tumors, results in B-cell depletion. Int J Hematol. doi: 10.1007/s12185-017-2360-8.
CDB0532T αMHC-TCTP Takayuki Fujita Wenqian Cai, Takayuki Fujita, Yuko Hidaka, Huiling Jin, Kenji Suita, Mayo Shigeta, Hiroshi Kiyonari, Masanari Umemura, Utako Yokoyama, Junichi Sadoshima & Yoshihiro Ishikawa. (2019) Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell Death & Diseasevolume 10, Article number: 549 (2019) TCTP is expressed under the control of αMHC promoter.
CDB0533T inducuible PKAc α Yasushi Fujio Imaeda A, Tanaka S, Tonegawa K, Fuchigami S, Obana M, Maeda M, Kihara M, Kiyonari H, Conway SJ, Fujio Y, Nakayama H. (2019) Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice. Biochem Biophys Res Commun. 510(1):149-155. This transgene carries the PKAcα downstream of CAG promoter and a floxed-CAT gene. PKAcα was overexpressed after excision of the floxed-CAT gene by Cre-mediated recombination.
CDB0535T Cdhr1tTA Tatsumi Hirata Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019. After Cre-loxP recombination, tTA is expressed in olfactory bulb projection neurons.
CDB0536T H-MOR28-iCre Haruki Takeuchi Ai Nakashima, Naoki Ihara, Mayo Shigeta, Hiroshi Kiyonari, Yuji Ikegaya, Haruki Takeuchi. (2019) Structured spike series specify gene expression patterns for olfactory circuit formation. Science Vol. 365, Issue 6448, eaaw5030 Cre recombinase is expressed in MOR28 expressing olfactory sensory neurons.
CDB0537T H-I7-iCre Haruki Takeuchi Ai Nakashima, Naoki Ihara, Mayo Shigeta, Hiroshi Kiyonari, Yuji Ikegaya, Haruki Takeuchi. (2019) Structured spike series specify gene expression patterns for olfactory circuit formation. Science Vol. 365, Issue 6448, eaaw5030 Cre recombinase is expressed in I7 expressing olfactory sensory neurons.
CDB0539T Acta2-LSL-mKO1 Kouji Matsushima Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K. (2019) Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis. Biochem Biophys Res Commun. 514(3):684-690. This transgenic mouse line expresses monomeric Kusabira Orange 1 (mKO1) under Acta2 promoter after Cre recombination. Although the transgene includes dLNGFR-CreER sequence under Col1a2 enhancer, the mRNA of dLNGFR-CreER has not been detected and no CreER recombinase activity was obsereved in this mouse line itself so far. See the original article about the construct of transgene. The transgene is inserted on the Y chromosome.
CDB0551T

(RBRC02597)

Hes7-Cre Kageyama Ryuichiro Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, Chu-Xia.and Kageyama, R. The Initiation and Propagation of Hes7 Oscillation Are Cooperatively Regulated by Fgf and Notch Signaling in the Somite Segmentation Clock. Dev Cell. . 13, 298-304, 2007 Cre is expressed in the presomitic mesoderm and its derivatives.
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CDB Acc.No. Genetic Sign mutation Type Corresponding Researcher Original paper
CDB0032E Tsukushi conditional Kunimasa Ohta Ito, N., Riyadh, M. A., Ahmad, S. A. I., Hattori, S., Kanemura, Y., Kiyonari, H., Abe, T., Furuta, Y., Shinmyo, Y., Kaneko, N., Hirota, Y., Lupo, G., Hatakeyama, J., Abdulhaleem, M. F., Anam, M. B., Yamaguchi, M., Takeo, T., Takebayashi, H., Takebayashi, M., Oike, Y., Nakagata, N., Shimamura, K., Holtzman, M. J., Takahashi, Y., Guillemot, F., Miyakawa, T., Sawamoto, K., & Ohta, K. (2021). Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Sci Transl Med, 13(587).
CDB0033E CCL11/eotaxin: Camsap3 KO Masatoshi Takeichi Mitsuhata, Y., Abe, T., Misaki, K., Nakajima, Y., Kiriya, K., Kawasaki, M., Kiyonari, H., Takeichi, M., Toya, M., & Sato, M. (2021). Cyst formation in proximal renal tubules caused by dysfunction of the microtubule minus-end regulator CAMSAP3. Sci Rep, 11(1), 5857.
CDB0039E Rab44 KO (deletion) Takayuki Tsukuba Kadowaki T, Yamaguchi Y, Kido MA, Abe T, Ogawa K, Tokuhisa M, Gao W, Okamoto K, Kiyonari H, Tsukuba T.(2020) The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis. Cell Mol Immunol. doi: 10.1038/s41423-020-0413-z.
CDB0056E Tacr3 IRES-Cre KI Tomomi Shimogori Onishi, K., Kikuchi, S. S., Abe, T., Tokuhara, T., & Shimogori, T. (2021). Molecular cell identities in the mediodorsal thalamus of infant mice and marmoset. J Comp Neurol.
CDB0154E C1qa KI Kouji Matsushima Ogawa T, Shichino S, Ueha S, Bando K, Matsushima K. (2022) Profibrotic properties of C1q + interstitial macrophages in silica-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 599:113-119.