mutant list
Here is the list of mouse lines generated by LARGE under joint development with investigators in RIKEN or researchers in academic institutions. These mouse lines are available to the scientific community.
To request the mutant mouse line of your interest, please contact “mutant.bdr(at)riken.jp”.
Gene Targeting
Please scroll left and right to see
| CDB Acc.No. （BRC No.） |
Genetic Sign | mutation Type | Corresponding Researcher | Original paper | |
|---|---|---|---|---|---|
| CDB0001K （RBRC02575） |
p53(-) | Shinichi Aizawa | Tsukada, T., Tomooka, Y., Takai, S., Ueda, Y., Nishikawa, S., Yagi, T., Tokunaga, T., Takeda, N., Suda, Y., Matsuo, I., Ikawa, Y. and Aizawa, S. (1993). Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene 8, 3313-3322. | ||
| CDB0002K | tenascin(lacZ) | Shinichi Aizawa | Saga, Y., Yagi, T., Sakakura, T., Ikawa, Y. and Aizawa, S. (1992). Mice develop normally without tenascin. Genes Dev. 6, 1821-1823 | ||
| CDB0003K | fyn(lacZ) | Shinichi Aizawa | Yagi, T., Shigetani, Y., Okado, N., Ikawa, Y. and Aizawa, S. (1993). Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ. Oncogene 8, 3343-3351. | ||
| CDB0004K | Csk(-) | Shinichi Aizawa | Nada, S., Yagi, T., Takeda, H., Tokunaga, T., Nakagawa, H., Ikawa, Y., Okada, M. and Aizawa, S.* (1993). Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73, 1125-1135. | ||
| CDB0005K （RBRC02576） |
mos(-) | Shinichi Aizawa | Hashimoto, N., Watanabe, N., Fruta, Y., Tamemoto, H., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. and Aizawa, S.* (1994). Parthenogenetic activation of oocytes, but normal spermatogenesis and somatic cell growth, by c-mos-deficiency in mice. Nature 370, 68-71. | ||
| CDB0006K | Fak(-) | Shinichi Aizawa | Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S.* (1995). Reduced cell motility and enhanced focal adhesion contact formationin cells from FAK-deficient mice. Nature 377, 539-544. | ||
| CDB0007K | Pat12 a gene trap clone | Shinichi Aizawa | Yoshida, M., Yagi, T., Furuta, Y., Takayanagi, K., Kominami, R., Takeda, N., Tokunaga, T., Chiba, J., Ikawa, Y. and Aizawa, S. (1995) A new strategy of gene trapping in ES cells using 3'RACE. Transgenic Res.,4, p277-287. | ||
| CDB0008K | Srm(-) | Shinichi Aizawa | Kohmura, N., Yagi, T., Tomooka, Y., Oyanagi, M., Kominami, R., Takeda, N., Chiba, J., Ikawa, Y. and Aizawa, S. (1994). A novel non-receptor tyrosine kinase, srm; cloning and targeted disruption. Mol. Cell. Biol. 14, 6915-6925. | ||
| CDB0009K | fyn(Csk) | Shinichi Aizawa | Kanazawa, S., Ilic, D., Hashiyama, M., Okada, M., Nomura, T., Aizawa, S. and Suda, T. (1996). Impaired development of CD4+ CD8+ thymocytes by csk-"knock-in" into fyn locus. Oncogene 13, 199-204. | ||
| CDB0010K （RBRC02270） |
Otx2(-) | Shinichi Aizawa | Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. and Aizawa, S. (1995). Mouse Otx2 functions in the formation and patterning of rostral head. Genes & Dev. 9, 2646-2658. | ||
| CDB0011K （RBRC02990） |
Otx2(lacZ) | Shinichi Aizawa | Kimura, C., Yoshinaga, K., Tian, E., Suzuki, M., Aizawa, S., and Matsuo, I. (2000) Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Developmental Biology 225, 304-321. | ||
| CDB0012K | Otx2 conditional Otx2frt Neo-d1 lox | Shinichi Aizawa | Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223. | ||
| CDB0013K （RBRC02271） |
Otx2 conditional KO flox | Shinichi Aizawa | Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223. | ||
| CDB0014K （RBRC02998） |
Otx2 conditional Δprox1 | Shinichi Aizawa | Tian, E., Kimura, C., Takeda, N., Aizawa, S. and Matsuo, I. (2002). Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification. Developmental Biology 242, 204-223. | ||
| CDB0015K | Otx2(Otx1) | Shinichi Aizawa | Suda, Y., Nakabayashi, J., Matsuo, I. and Aizawa, S. (1999). Functional equivalency between Otx2 and Otx1 in development of the rostral head. Development 126, 743-757. | ||
| CDB0016K | Otx2(Emx2) | Shinichi Aizawa | Suda, Y., Houssain, Z. M., Kobayashi, C., Hatano, O., Yoshida, M., Matsuo, I. and Aizawa, S. (2001). Emx2 directs the development of diencephalon in cooperation with Otx2. Development 128, 2433-2450. | ||
| CDB0017K （RBRC02577） |
Otx1(-) | Shinichi Aizawa | Suda, Y., Matsuo, I. and Aizawa, S. (1997). Cooperation between Otx1 and Otx2 genes in developemtal patterning of rostral brain. Mech. Dev. 69, 125-141. | ||
| CDB0018K （RBRC02983） |
Emx2(-) | Shinichi Aizawa | Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997). Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124, 101-111. | ||
| CDB0020K （RBRC02272） |
Emx2(Cre) | Shinichi Aizawa | Kimura, J., Suda, Y., Kurokawa, D., Houssain, ZM., Nakamura, M., Takahashi, M., Hara, A. and Aizawa, S. (2005) Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That Includes Future Archip-allium. The Journal of Neuroscience 25, 5097-5108. | ||
| CDB0021K （RBRC02273） |
Emx1(-) | Shinichi Aizawa | Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997). Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124, 101-111. | ||
| CDB0022K （RBRC02578） |
CHK/HYL(-) | Shinichi Aizawa | Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S.and Suda,T.(1996). Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Biochem. Biophys. Res. Commun. 224, 172-179. | RBRC02578 | |
| CDB0024K （RBRC02274） |
ang(lacZ):4400 | Shinichi Aizawa | Murata, T., Furushima, K., Hirano, M., Kiyonari, H., Nakamura, M., Suda, Y. and Aizawa, S. (2004) ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Gene Expression Patterns 5, 171-178. | ||
| CDB0025K （RBRC02275） |
ｃｆｍ(-): 5170 | Shinichi Aizawa | Hirano, M., Murata, T., Furushima, K., Kiyonari, H., Nakamura, M., Suda, Y. and Aizawa, S. (2005) cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype. Gene Expression Patterns, 5 439-444. | ||
| CDB0027K （RBRC02276） |
Opr(-) | Shinichi Aizawa | Furushima, K., Murata, T., Kiyonari, H. and Aizawa, S. (2005) Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedical telencephalon and medioventral forebrain (p NA). Developmental Dynamics 232, 1056-1061. | ||
| CDB0029K （RBRC02277） |
Omphk1(lacZ): 6057 | Shinichi Aizawa | Mariko Hirano, Hiroshi Kiyonari, Ai Inoue, Kenryo Furushima, Takuya Murata,Yoko Suda and Shinichi Aizawa （2006）. A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. Developmental Dynamics 235, 2229-2237. | ||
| CDB0030K | dkk1(Venus) | Shinichi Aizawa | Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492. | ||
| CDB0032K | Epb4.1-like5(lacZ): 5156 | Shinichi Aizawa | Hirano, M., Hashimoto, S., Yonemura, S., Sabe, H. and Aizawa, S. (2008). EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. Journal of Cell Biology 182 1217-1230. | ||
| CDB0044K | mShisa(lacZ): BS50-2 | Shinichi Aizawa | Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492. | ||
| CDB0045K | mShisa３（lacZ): BS50-3 | Shinichi Aizawa | Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492. | ||
| CDB0046K | mShisa4(lacZ): BS50-1 | Shinichi Aizawa | Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492. | ||
| CDB0047K | mShisa5(IRES-lacz): BS50-4 | Shinichi Aizawa | Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima, N., Kiyonari, H. and Aizawa, S. (2007). Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Developmental Biology 306, 480-492. | ||
| CDB0048K | WISE | KI(AFP) | Nobue Itasaki | Shigetani, Y., Howard, S., Guidato, S., Furushima, K., Abe, T. and Itasaki, N. Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. Developmental Biology, 319（Ⅱ）,346-358,2008 | |
| CDB0049K （RBRC02992） |
Otx2(DAN) | Shinichi Aizawa | Kurokawa, D., Takasaki, N., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development, 131, 3307-3317. | ||
| CDB0050K （RBRC02993） |
Otx2(DFM1) | Shinichi Aizawa | Kurokawa, D., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development, 131, 3319-3331. | ||
| CDB0051K （RBRC03078） |
Otx2(DFM2) | Shinichi Aizawa | Kurokawa, D., Kiyonari, H., Nakayama, R., Kimura, C., Matsuo, I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development, 131, 3319-3331. | ||
| CDB0064K | Otx2(DFM1DFM2) | Shinichi Aizawa | Sakurai Y, Kurokawa D, Kiyonari H, Kajikawa E, Suda Y, Aizawa S. (2010) Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 347(2): 392-403. | ||
| CDB0071K （RBRC05268） |
microRNA9-3 | KO(simple knock-out) | Shinichi Aizawa | Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S. (2011) MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 31(9): 3407-3422. | |
| CDB0072K （RBRC05269） |
microRNA9-2 | KO(simple knock-out) | Shinichi Aizawa | Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S. (2011) MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 31(9): 3407-3422. | |
| CDB0075K | Sfrp1(lacZ) | Akihiko Shimono | Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 133(6): 989-999. | ||
| CDB0076K | Sfrp2(-) | Akihiko Shimono | Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 133(6): 989-999. | ||
| CDB0077K | Sfrp5(-) | Akihiko Shimono | Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 46(2): 92-103. | ||
| CDB0078K | Sfrp5(YFP) | Akihiko Shimono | Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 46(2): 92-103. | ||
| CDB0084K | Epb4.1l5(loxP) | conditional KO (loxP) | Shinichi Aizawa | Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB. (2017) The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Proc Natl Acad Sci U S A. 114(23):E4621-E4630. | |
| CDB0089K | AmotKO | Akihiko Shimono | Shimono A, Behringer RR. (2003) Angiomotin regulates visceral endoderm movements during mouse embryogenesis. Current Biology 13(7): 613-617. | ||
| CDB0092K | Dkk1(H2B-mCherry) | H2BmCherry KI | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | |
| CDB0098K | Hhex(CreERTM) | CreERTM KI | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | |
| CDB0103K | DKK1(d2EGFP) | degEGFP KI | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | |
| CDB0201K （RBRC05362） |
FAH | Shinichi Aizawa | Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H. Flow Cytometric Isolation and Clonal Identification of Self-Renewing Bipotent Hepatic Progenitor Cells in Adult Mouse Liver. Hepatology, 48(6), 1964-1978, 2008 | ||
| CDB0300K | R26-TRE-memGFP(KI) | Knockin | Tatsumi Hirata | Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019. | |
| CDB0311K | R26R-CAG-Nid1-mCherry | KI, conditional | Sugiko Futaki | Futaki S, Horimoto A, Shimono C, Norioka N, Taniguchi Y, Hamaoka H, Kaneko M, Shigeta M, Abe T, Sekiguchi K, Kondo Y. (2023) Visualization of basement membranes by a nidogen-based fluorescent reporter in mice. Matrix Biol Plus 18:100133. | |
| CDB0320K | R26-CAG-Nid1-mCherry | KI | Sugiko Futaki | Futaki S, Horimoto A, Shimono C, Norioka N, Taniguchi Y, Hamaoka H, Kaneko M, Shigeta M, Abe T, Sekiguchi K, Kondo Y. (2023) Visualization of basement membranes by a nidogen-based fluorescent reporter in mice. Matrix Biol Plus 18:100133. | |
| CDB0401K （RBRC04801） |
KCP(taulacZ): CR2X | Yoshiki Sasai | Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473. | ||
| CDB0402K （RBRC04802） |
Cv2(taulacZ): ＣＲ５ | Yoshiki Sasai | Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473. | ||
| CDB0403K | ARID3B(lacZ-neo):DRI2 LacZ neo | Shin-Ichi Nishikawa | Takebe, A., Era, T., Okada, M., Jakt, LM., Kuroda, Y. and Nishikawa, S-I. Microarray analysis of PDGFRa+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. Dev. Biol., 293, 25-37, 2006 |
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| CDB0404K （RBRC03505） |
Tead2 | LacZ-KI | Hiroshi Sasaki | Sawada, A., Kiyonari, H., Ukita, K., Nishioka, N., Imuta, Y. and Sasaki, H. Redundant Roles Of Tead1 and Tead2 in Notochord Development and Regulation of Cell Proliferation and Survival．Mol Cell Biol., 28/10., 3177-3189, 2008 | |
| CDB0409K （RBRC03506） |
Tead4 | LacZ-KI | Hiroshi Sasaki | Nishioka, N,. Yamamoto, S., Kiyonari, H., Sato, H., Sawada, A., Ota, M., Nakao, K. and Sasaki, H. Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.Mechanisms of Development., 125, 270-283, 2008 | |
| CDB0410K （RBRC03507） |
Tead1 | LacZ-KI | Hiroshi Sasaki | Sawada, A., Kiyonari, H., Ukita, K., Nishioka, N., Imuta, Y. and Sasaki, H. Redundant Roles Of Tead1 and Tead2 in Notochord Development and Regulation of Cell Proliferation and Survival．Mol Cell Biol., 28/10., 3177-3189, 2008 | |
| CDB0411K （RBRC02589） |
mONT3(nlacZ): mONT1 | KI(nLacZ) | Yoshiki Sasai | Ikeya, M., Kawada, M., Nakazawa, Y., Sakuragi, M., Sasai, N., Ueno, M., Kiyonari, H., Nakao, K.and Sasai, Y. Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations. Int J Dev Biol. 49(7), 807-823, 2005 | |
| CDB0412K | ARID3B(lacZ):DRI2 LacZ | Shin-Ichi Nishikawa | Takebe, A., Era, T., Okada, M., Jakt, LM., Kuroda, Y. and Nishikawa, S-I. Microarray analysis of PDGFRa+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. Dev. Biol., 293, 25-37, 2006 |
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| CDB0413K （RBRC02590） |
JamB(ires-β geo):Jcam2 | KI(ires-β geo) | Akihiko Okuda | Sakaguchi, T., Nishimoto, M., Miyagi, S., Iwama, A., Morita, Y., Iwamori, N., Nkauchi, H., Kiyonari, H., Muramatsu, M.and Okuda, A.Putative "Sstemness"Gene Jam-b Is Not Required for Maintenance of Stem Cell State in Embryonic,Neural, or Hematopoietic Stem Cells. Mol Cell Biol.: 26(17), 6557-6570, 2006. | |
| CDB0414K （RBRC02591） |
mGIT2 | KO(simple knock-out) | Hisataka Sabe | Mazaki, Y., Hashimoto, S.,Tsujimura, Y., Morishige, M., Hashimoto, S., Aritake, K., Yamada, A., Jin-Min, Nam., Kiyonari, H., Nakao, K.and Sabe, H. Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nature Immunology : 7/7, 724-731, 2006. | |
| CDB0419K （RBRC11341） |
mDia2 | conditional | Shuh Narumiya | Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S. (2013) Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis. Cell Rep. 5(4): 926-32. | |
| CDB0420K （RBRC02593） |
Tamalin | KO(simple knock-out) | Shigetada Nakanishi | Ogawa, M., Miyakawa, T., Nakamura, K., Kitano, J., Furushima, K., Kiyonari, H., Nakayama, R., Nakao, K., Moriyoshi, K. and Nakanishi, S. Altered sensitivities to morphine and cocaine in scaffold proein tamalin knockout mice. Proc. Natl. Acad. Sci. USA: 104/37, 14789-14794, 2007. | |
| CDB0422K （RBRC02594） |
septin-3(-) | KO | Mineko Kengaku | Fujishima, K., Kiyonari, H., Kurisu, J., Hirano, T.and Kengaku, M.Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.J Neurochem.：102,1377-1388,2007 | |
| CDB0426K | mDia3 | conditional | Shuh Narumiya | Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S.A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.Nat Neurosci. 15(3):373-380, 2012. | |
| CDB0427K （RBRC09355） |
SMAP1 | KO(simple knock-out) | Masanobu Satake | Kon S, Minegishi N, Tanabe K, Watanabe T, Funaki T, Wong WF, Sakamoto D, Higuchi Y, Kiyonari H, Asano K, Iwakura Y, Fukumoto M,Osato M, Sanada M, Ogawa S, Nakamura T, Satake M. (2013) Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest.123(3):1123-37. | |
| CDB0428K | pp2C-epsilon | KI(lacZ KI) | Takayasu Kobayashi | Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y, Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T. (2016) Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain. FEBS Lett. 590(20):3606-3615. | |
| CDB0430K （RBRC03508） |
Slingshot3 | LacZ-KI | Tadashi Uemura | Kousaka K, Kiyonari H, Oshima N, Nagafuchi A, Shima Y, ChisakaO, Uemura T.,Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development..:Genesis.45(5), 246-255, 2008. | |
| CDB0431K （RBRC05273） |
mpk1(lacZ):mpk15 | Naoto Ueno | Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N. (2009) Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 106(34): 14426-14431. | ||
| CDB0433K （RBRC05274） |
Borealin:N196 | Tatsutoshi Nakahata | Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, Kitano A, Shiraishi K, Kato T, Nagato M, Okawa K, Furushima K, Nakao K, Nakamura Y, Taketo MM, Aizawa S, Nakahata T. (2008) Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 125(5-6): 441-450. | ||
| CDB0434K （RBRC05275） |
Vlk：24247(Venus-neo):24247-venus-LNL | Shin-Ichi Nishikawa | Kinoshita M, Era T, Jakt LM, Nishikawa S. (2009) The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development. 136(12): 2069-2079. | ||
| CDB0435K （RBRC09345） |
mpk2(-):mpk6 | KO(simple knock-out) | Naoto Ueno | Tao H, Manak JR, Sowers L, Mei X, Kiyonari H, Abe T, Dahdaleh NS, Yang T, Wu S, Chen S, Fox MH, Gurnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaideb SN, El-Shanti H, Mahajan VB, Ferguson PJ, Axelrod JD, Lehesjoki AE, Fritzsch B, Slusarski DC, Wemmie J, Ueno N, Bassuk AG.Mutations in prickle orthologs cause seizures in flies, mice, and humans.Am J Hum Genet. 2011 Feb 11;88(2):138-49. | |
| CDB0437K （RBRC002595） |
mDia1 | KI(loxP, conditional) | Shuh Narumiya | Sakata, D., Taniguchi, H., Yasuda, S,. Adachi-Morishima,A., Hamazaki, Y., Nakayama, R., Miki, T., Minato, N. and Narumiya, S. Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. The Journal of Experimental Medicine:204/9, 2031-2038, 2007. | |
| CDB0438K | RGC Fantom 1 | loxP KI | Shinichi Nakagawa | Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. (2016) Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 6:27204. doi: 10.1038/srep27204. | |
| CDB0439K | RGC Fantom 2 | loxP KI | Shinichi Nakagawa | Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. (2016) Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 6:27204. doi: 10.1038/srep27204. | |
| CDB0440K （RBRC05276） |
Kif-k | Ryuichi Nishinakamura | Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R. (2010) Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 107(20): 9240-9245. | ||
| CDB0442K （RBRC03509） |
TRB2(lacZ) | LacZ-KI | Ryuichi Nishinakamura | Takasato M, Kobayashi C, Okabayashi K,Kiyonari H, Oshima N, Asashima M, Nishinakamura Ryuichi., Trb2, a mouse homeolog of tribble, is dispensable for kidney and mouse development.:Biochemical and Biophysical Research Communications.373, 648-652, 2008. | |
| CDB0444K （RBRC05277） |
Fgf-bp3:N153 | Tatsutoshi Nakahata | Yamanaka Y, Kitano A, Takao K, Prasansuklab A, Mushiroda T, Yamazaki K, Kumada T, Shibata M, Takaoka Y, Awaya T, Kato T, Abe T, Iwata N, Miyakawa T, Nakamura Y, Nakahata T, Heike T.Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Mol Cell Neurosci. 2011 Jan;46(1):200-12. | ||
| CDB0445K | TMX | KO(simple knock-out) | Junji Yodoi | Matsuo, Y., Irie, K., Kiyonari, H., Okuyama, H., Nakamura, H., Son, A., Lopez-Ramos, DA., Tian, H., Oka, S., Okawa, K., Kizaka-Kondoh, S., Masutani, H. and Yodoi, J. (2013) The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury. Antioxid Redox Signal. 18(11): 1263-72. | |
| CDB0451K （RBRC04803） |
Cv2(nlacZ): CR5 | Yoshiki Sasai | Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 133(22):4463-4473. | ||
| CDB0452K （RBRC003511） |
LGN(loxP,venus)：LGN-venusC | KI(loxP, venus) | Fumio Matsuzaki | Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol. 10(1), 93-101, 2008. | |
| CDB0454K （RBRC05286） |
Mdga1(-) | KI(lacZ KI) | Tohru Yamamoto | Ishikawa T, Gotoh N, Murayama C, Abe T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T. (2011) IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Dev Dyn. 240(1): 96-107. | |
| CDB0455K （RBRC02596） |
Ripply2 | KI(lacZ KI) | Makoto Asashima | Chan T, Kondow A, Hosoya A, Hitachi K, Yukita A, Okabayashi K, Nakamura H, Ozawa H, Kiyonari H, Michiue T, Ito Y, Asashima M.(2007) Ripply2 is essential for precise somite formation during mouse early development. FEBS Letters 581,2691-2696 | |
| CDB0457K （RBRC11336） |
PKN3(-) | KO(simple knock-out) | Hideyuki Mukai | Mukai, H., Muramatsu, A., Mashud, R., Kubouchi, K., Tsujimoto, S., Hongu, T., Kanaho, Y., Tsubaki, M., Nishida, S., Shioi, G., Danno, S., Mehruba, M., Satoh, R. and Sugiura, R. (2016) PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep. 6:18979. doi: 10.1038/srep18979. | |
| CDB0458K | Runx3(loxP) | conditional | Masanobu Satake | Ogawa E, Edamitsu T, Ohmori H, Kohu K, Kurokawa M, Kiyonari H, Satake M, Okuyama R. (2022) Transcription factors Runx1 and Runx3 suppress keratin expression in undifferentiated keratinocytes. Int. J. Mol. Sci. 23(17), 10039. | |
| CDB0463K （RBRC05646） |
PLCeta | KI(lacZ KI) | Kiyoko Fukami | Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K.Phospholipase C-eta2 is highly expressed in the habenula and retina.Gene Expr Patterns. 2010 Feb-Mar;10(2-3):119-26. Epub 2010 Jan 11. | |
| CDB0465K | TTYH1 | KO(simple knock-out) | Tatsutoshi Nakahata | Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, Okawa K, Abe T, Oshima N, Nakahata T, Heike T. (2010) Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 239(8): 2233-2245. | |
| CDB0466K （RBRC05280） |
nrd1(lacZ) | Eiichirou Nishi | Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, Nishi E. (2009) Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 12(12): 1506-1513. | ||
| CDB0467K （RBRC03512） |
R-spondin2(lacZ):Cabriolet-2 | LacZ-KI | Hitoshi Okamoto | Aoki M, Kiyonari H, Nakamura H, Okamoto H., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development.:Dev Growth Differ.50(2), 85-95, 2008. | |
| CDB0468K | CNOT6L(LacZ) | KI(lacZ KI) | Tadashi Yamamoto | Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N. (2019) Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proc Natl Acad Sci U S A. 116(16):7973-7981. | |
| CDB0471K （RBRC09329） |
Chemerin：AC1 | KI(lacZ KI) | Yutaka Takahashi | Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS,Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y. Chemerin regulates β-cell function in mice. SCIENTIFIC REPORTS. 2011 Oct 19. | |
| CDB0474K （RBRC11340） |
Dullard(lacZ) | KI(lacZ KI) | Ryuichi Nishinakamura | Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R. Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428. | |
| CDB0475K （RBRC03513） |
Intestine specific homeobox(Isn):Pix-1 | LacZ-KI | Susumu Seino | Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S.Intestine specific homeobox (ISX) participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15, 15'-monooxygenase (bcmo1) expression.J Biol Chem. 283.4905-4911.2008 | |
| CDB0476K （RBRC03514） |
hrs(loxP) | Kazuo Sugamura Nobuyuki Tanaka |
Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N, Watanabe M, Sugamura K. (2008) Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am J Pathol. 173(6): 1806-1817. | ||
| CDB0478K | LMIR3 | KO(simple knock-out) | Jiro Kitaura | Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J. (2012). The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37(5):827-39. | |
| CDB0479K （RBRC03515） |
Aire(GFP):Aire-KI | KI(GFP) | Mitsuru Matsumoto | Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, and Matsumoto M.（2008）Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.JEM.205.2827-2838 (*CDB0483K) | |
| CDB0480K | GPRC 5B | KI(lacZ KI) | Yoshio Hirabayashi | T Sanoa, Y-J Kima, E Oshimaa, C Shimizu, H Kiyonari, T Abe, H Higashi, K Yamada, Y Hirabayashi. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Biochemical and Biophysical Research Communications 412 (2011) 460–465. | |
| CDB0481K （RBRC03516） |
S gene(lacZ) | LacZ-KI | Mitsuru Matsumoto | Matsumoto, M., Zhou, Y., Matsuo, S., Nakanishi, H., Hirose, K., Oura, H., Arase, S., Ishida-Yamamoto, A., Bando, Y., Izumi, K., Kiyonari, H., Oshima, N., Nakayama, R., Matsushima, A., Hirota, F., Mouri, Y., Kuroda, N., Sano, Shigetoshi. and David D. Chaplin. Tageted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc. Natl. Acad. Sci. : 105/18, 6720-6724, 2008. | |
| CDB0482K | Prox1 | floxed Prox1 cDNA-KI, EGFP | Fumio Matsuzaki | Iwano T, Masuda A, Kiyonari H, Enomoto H, Matsuzaki F., Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus. Development. 2012 Aug;139(16):3051-62. Epub 2012 Jul 12. | |
| CDB0483K （RBRC03517） |
RhoH(lacZ) | KO(simple knock-out) | Mutsunori Shirai | Hiroyo Oda, Manabu Fujimoto, Michael S. Patrick, Dai Chida, Yoshinori Sato, Yoshinao Azuma, Hiroki Aoki, Takaya Abe, Harumi Suzuki and Mutsunori Shirai. (2009) RhoH Plays Critical Roles in FceRI-dependent Signal Transduction in Mast Cells. The Journal of Immunology,182: 957-962. | |
| CDB0484K （RBRC03518） |
Draxin | KI(lacZ KI) | Yohei Shinmyo | Shahidul M.Islam, Yohei Shinmyo, Tatsuya Okafuji, Yuhong Su, Iftekhar Bin Nase, Giasuddin Ahmed, Sanbing Zhang, Sandy Chen, Kunimasa Ohta, Hiroshi Kiyonari, Takaya Abe, Satomi Tanaka, Ryuichi Nishinakamura, Toshio Terashima, Toshio Kitamura, Hideaki Tanaka.(2009) Draxin, a Repulsive Guidanc Protein for Spinal Cord and Forebrain Commissures. Science 323,388-393. | |
| CDB0485K | GPRC 5C | KI(lacZ KI) | Yoshio Hirabayashi | T Sanoa, Y-J Kima, E Oshimaa, C Shimizu, H Kiyonari, T Abe, H Higashi, K Yamada, Y Hirabayashi. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Biochemical and Biophysical Research Communications 412 (2011) 460–465. | |
| CDB0487K | Sox13 | KI(lacZ KI) | Shin-Ichi Osada | Noto M, Noguchi N, Ishimura A, Kiyonari H, Abe T, Suzuki T, Hasunuma N, Taira M, Manabe M, Osada SI. Sox13 is a novel early marker for hair follicle development. Biochem Biophys Res Commun. 2019 Jan 10. pii: S0006-291X(18)32844-4. doi: 10.1016/j.bbrc.2018.12.163. | |
| CDB0488K （RBRC09352） |
RECK | Makoto Noda | Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M. (2010). Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol 10:84. doi: 10.1186/1471-213X-10-84. | ||
| CDB0490K | cdh8(gapLacZ/flox neo) | Masatoshi Takeichi | Suzuki SC, Furue H, Koga K, Jiang N, Nohmi M, Shimazaki Y, Katoh-Fukui Y, Yokoyama M, Yoshimura M, Takeichi M. (2007) Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 27(13): 3466-3476. | ||
| CDB0491K | cdh8(tauLacZ/flox neo) | Masatoshi Takeichi | Suzuki SC, Furue H, Koga K, Jiang N, Nohmi M, Shimazaki Y, Katoh-Fukui Y, Yokoyama M, Yoshimura M, Takeichi M. (2007) Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 27(13): 3466-3476. | ||
| CDB0492K | Cryptochrome2 | KI(lacZ KI) | Yoshitaka Fukada | Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y. (2014). In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock. Mol Cell Biol. 34(24):4464-4473. | |
| CDB0494K | cdh6(-) | Masatoshi Takeichi | Inoue T., Tanaka T., Takeichi M., Chisaka O., Nakamura S., and Osumi N. (2001) Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development 128. 561-569. | ||
| CDB0495K | cdh11(-) | Masatoshi Takeichi | Manabe T., Togashi H., Uchida N., Suzuki S.C., Hayakawa Y., Yamamoto M., Yoda H., Miyakawa T., Takeichi M., and Chisaka O. (2000) Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses. Mol Cell Neurosci 15. 534-546. | ||
| CDB0496K | ctnna2(EGFP) | Masatoshi Takeichi | Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. (2002) Cadherin regulates dendritic spine morphogenesis. Neuron. 35(1): 77-89. | ||
| CDB0497K | Fez(-)：Fez(pgk-neo) | Masahiko Hibi | Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y.and Hibi, M. Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development. 133(8), 1433-1443, 2006 | ||
| CDB0498K | Fezl(lacZ)：Fezl(LacZ-MC1-neo) | Masahiko Hibi | Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T.and Hibi, M. Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.Dev Dyn.230(3), 546-556, 2004 | ||
| CDB0500K （RBRC04774） |
Dnmt1 | Masaki Okano | Takebayashi, S.I., Tamura, T., Matsuoka, C., and Okano, M. (2007).Major and Essential Role for the DNA Methylation Mark in Mouse Embryogenesis and Stable Association of DNMT1 with Newly Replicated Regions. Mol Cell Biol 27, 8243-8258. | ||
| CDB0502K （RBRC03519） |
Cthrc1 | KI(lacZ KI) | Hiroshi Sasaki | Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.Dev. Cell 15, 23-36, 2008. | |
| CDB0518K | Ret-CreERT2 | CreERT2 KI | Hideki Enomoto | Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F.(2009) Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell. 17(2): 199-209. | |
| CDB0524K | Runx-1(Mer-Cre-Mer)：Runx-1(Mer-Cre-Mer, HSV TK -neo) | Igor M Samokhvalov | Samokhvalov IM, Samokhvalova NI, Nishikawa S. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007 Apr 26;446(7139):1056-61 | ||
| CDB0525K （RBRC05065） |
Sox1(Cre) | Shin-Ichi Nishikawa | Takashima Y, Era T, Nakao K, Kondo S, Kasuga M, Smith AG, Nishikawa S. (2007) Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell. 129(7): 1377-1388. | ||
| CDB0530K | pkd2 | KO(simple knock-out) | Takahiko Yokoyama | Takao D, Nemoto T, Abe T, Kiyonari H, Kajiura-Kobayashi H, Shiratori H, Nonaka S. (2013) Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Dev Biol. 376(1):23-30. | |
| CDB0531K （RBRC05281） |
LTbR | KI(lacZ KI) | Mitsuru Matsumoto | Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M. Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma.J Immunol. 2011;186(9):5047-57. | |
| CDB0535K （RBRC04815） |
NIPSNAP1 | KO(simple knock-out) | Emiko Ashitaka | Okuda-Ashitaka E, Minami T, Tsubouchi S, Kiyonari H, Iwamatsu A, Noda T, Hanada H and Ito S. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem. 287(13), 10403-10413, 2012. | |
| CDB0537K （RBRC03520） |
AW548124 | KO | Hiroshi Sasaki | Imuta Y, Nishioka N, Kiyonari H, Sasaki H.Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124).Dev.Dyn. 238,210-222, 2009 | |
| CDB0539K （RBRC05282） |
LMIR5(Lenococyte-momo-lg-like receptor3) | Toshio Kitamura | Yamanishi Y, Kitaura J, Izaawa K, Kitani A, Komeno Y, Nakamra M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.(2010) TIM1 is an endogenous ligand for LMIR5/CD300b:LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.JEM 207,1501-1511. | ||
| CDB0540K | CITED2 | conditional | Michihiro Matsumoto | Tsukasaki, M., N. C. Huynh, K. Okamoto, R. Muro, A. Terashima, Y. Kurikawa, N. Komatsu, W. Pluemsakunthai, T. Nitta, T. Abe, H. Kiyonari, T. Okamura, M. Sakai, T. Matsukawa, M. Matsumoto, Y. Kobayashi, J. M. Penninger and H. Takayanagi (2020). Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab 2(12): 1382-1390. | |
| CDB0542K | Epac1 | KO(simple knock-out) | Yoshihiro Ishikawa | Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato M, Okumura S, Ishikawa Y. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010 Jul 30;285(31):24248-59. | |
| CDB0545K （RBRC09343） |
MOR215-1(swap) | Hitoshi Sakano | Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H. Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons. Cell. 2013 Sep 12;154(6):1314-25. doi: 10.1016/j.cell.2013.08.033. | ||
| CDB0546K （RBRC09344） |
MOR215-1(tagging) | Hitoshi Sakano | Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H. Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons. Cell. 2013 Sep 12;154(6):1314-25. doi: 10.1016/j.cell.2013.08.033. | ||
| CDB0547K | TSK(lacZ) | KI(lacZ KI) | Kunimasa Ohta | Ito, A., Shinmyo, Y., Abe, T., Oshima, N., Tanaka, H., Ohta, K. (2010). Tsukushi is required for anterior commissure formation in mouse brain. Biochem Biophys Res Commun. 402(4):813-8. | |
| CDB0548K | Dmrta4 | KO | Noriko Osumi | Kikkawa, T., Sakayori, N., Yuuki, H., Katsuyama, Y., Matsuzaki, F., Konno, D., Abe, T., Kiyonari, H., and Osumi, N. (2020). Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon. Dev Dyn 249, 698-710. | |
| CDB0549K | IAN4(loxP) | conditional | Yousuke Takahama | Yano, K., Carter, C., Yoshida, N., Abe, T., Yamada, A., Nitta, T., Ishimaru, N., Takada, K., Butcher, G. W. and Takahama, Y. (2014) Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol 44(2): 561-72. | |
| CDB0552K | PLCd1 | conditional | Kiyoko Fukami | Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K.Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun. 2012 Jul 17;3:963. doi: 10.1038/ncomms1960. | |
| CDB0553K （RBRC03521） |
PC/Glis3-exon5-Neo:pc/Glis3-GFP | Yuko Wakamatsu | Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H. (2009) A murine model of neonatal diabetes mellitus in Glis3-deficient mice. FEBS Lett. 583(12): 2108-2113. | ||
| CDB0555K （RBRC09347） |
NUAK1：Ark5 | conditional | Hiroyasu Esumi | Inazuka F, Sugiyama N, Tomita M, Abe T, Shioi G, Esumi H. (2012) Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. J Biol Chem. 287(20):16379-16389. | |
| CDB0556K | Sirh3 | KI | Tomoko Ishino | Irie M, Itoh J, Matsuzawa A, Ikawa M, Kiyonari H, Kihara M, Suzuki T, Hiraoka Y, Ishino F, Kaneko-Ishino T. (2022) Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain. Development 149(18):dev200976. | |
| CDB0557K | Sirh11 | conditional | Tomoko Ishino | Irie, M., Yoshikawa, M., Ono, R., Iwafune, H., Furuse, T., Yamada, I., Wakana, S., Yamashita, Y., Abe, T., Ishino, F., Kaneko-Ishino, T. (2015) Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians, PLoS Genet 11(9):e1005521. | |
| CDB0558K | Cbx3 | conditional | Yukiko Gotoh | Oshiro H, Hirabayashi Y, Furuta Y, Okabe S, Gotoh Y. (2015) Up-regulation of HP1γexpression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex. Genes Cells. 20(2):108-20. | |
| CDB0559K | IAN5 | KO(simple knock-out) | Yousuke Takahama | Yano, K., Carter, C., Yoshida, N., Abe, T., Yamada, A., Nitta, T., Ishimaru, N., Takada, K., Butcher, G. W. and Takahama, Y. (2014) Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol 44(2): 561-72. | |
| CDB0564K （RBRC09336） |
Dullard | conditional | Ryuichi Nishinakamura | Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R. (2013) The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth. Nat Commun. 4:1398. doi: 10.1038/ncomms2408. | |
| CDB0570K （RBRC11342） |
Epac2 | KO(simple knock-out) | Yoshihiro Ishikawa | Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. (2014) Epac1-dependent hospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest. 124(6):2785-2801. doi: 10.1172/JCI64784. | |
| CDB0575K （RBRC09339） |
Hormad1 | KO(simple knock-out) | Hiroki Kurahashi | Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012 ;17(6):439-54. | |
| CDB0576K （RBRC09340） |
Hormad2 | KO(simple knock-out) | Hiroki Kurahashi | Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H. (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 17(11): 897-912. | |
| CDB0579K （RBRC05283） |
Noto(nmCherry-CreERT2) | Hiroshi Sasaki | Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H. (2009) Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev. 126(10): 791-803. | ||
| CDB0582K （RBRC11337） |
CLPABP | KO(simple knock-out) | Hisaaki Taniguchi | Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H. (2016) Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim Biophys Acta. 1861(11):1816-1827. | |
| CDB0583K （RBRC03709） |
DISC１ | KO(simple knock-out) | Kozo Kaibuchi | Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K,Kaibuchi K., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.: Hum Mol Genet. 20(23), 4666-4683, 2011. | |
| CDB0584K （RBRC11345） |
CNOT8(loxP) | KO(simple knockout) conditional KO |
Toru Suzuki Tadashi Yamamoto |
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T. (2020) Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Jan 10:1-14. | |
| CDB0585K | CEB1/HERC5(-) | KO(simple knock-out) | Kunitada Shimotohno | Arimoto K, Hishiki T, Kiyonari H, Abe T, Cheng C, Yan M, Fan JB, Futakuchi M, Tsuda H, Murakami Y, Suzuki H, Zhang DE, Shimotohno K. (2015) Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res. 35(5):351-8. | |
| CDB0587K | Sfrp4 | lacZ-neo KI | Sohei Kitazawa | Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, Abe T, Kitazawa S. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198. doi: 10.1038/srep25198. | |
| CDB0589K | APBA3(loxP) | conditional | Motoharu Seiki | Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T.Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.J Biol Chem. 2011 Sep 16;286(37):32542-51. Epub 2011 Jul 21. | |
| CDB0590K （RBRC09338） |
GTRAP3-18 | KO(simple knock-out) | Toshio Nakaki | Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M, Nakaki T. Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice. Neurobiol Dis. 2012 Mar;45(3):973-982. | |
| CDB0597K | Fhod1(lacZ):Fhod1/Fhos1 | LacZ KI | Hideki Sumimoto | Sanematsu F, Kanai A, Ushijima T, Shiraishi A, Abe T, Kage Y, Sumimoto H, Takeya R. (2019) Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice. Cytoskeleton (Hoboken). 76(2):219-229. | |
| CDB0598K | Fhod3 knockout | KO | Ryu Takeya | Kan-o M, Takeya R, Abe T, Kitajima N, Nishida M, Tominaga R, Kurose H, Sumimoto H. (2012) Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.Biol Open.1:889-896. | |
| CDB0599K （RBRC05285） |
Crtac1 | KO(simple knock-out) | Kohtaro Takei | Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011 Aug 5;333(6043):769-73. | |
| CDB0601K | Foxa2(Foxa2-2A-nuc-EGFP-2A-CreER) | KI | Hiroshi Sasaki | Imuta Y, Kiyonari H, Jang CW, Behringer RR, Sasaki H. (2013) Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar;51(3):210-8. | |
| CDB0602K （RBRC09332） |
Arid5a | KO(simple knock-out) | Riko Nishimura | Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T. (2013) Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc Natl Acad Sci U S A. 110(23): 9409-9414. | |
| CDB0603K （RBRC11343） |
Tdrd5 | KO(simple knock-out) | Mitinori Saitou | Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. (2011) TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 192(5): 781-95. | |
| CDB0604K | Brachyury(Brachyury2A-nuc-EGFP-2A-CreER) | KI | Hiroshi Sasaki | Imuta Y, Kiyonari H, Jang CW, Behringer RR, Sasaki H. (2013) Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar;51(3):210-8. | |
| CDB0605K | USP10(loxP) | conditional | Masahiro Fujii | Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M. (2016) USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Stem Cell Reports. 7(6):1116-1129. | |
| CDB0606K | DGKη | KO(simple knock-out) | Fumio Sakane | Isozaki T, Komenoi S, Lu Q, Usuki T, Tomokata S, Matsutomo D, Sakai H, Bando K, Kiyonari H, Sakane F. (2016) Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior. J Neurochem.138(3), 448-456. | |
| CDB0608K | PCDH17(lacZ) | KI(lacZ KI) | Tadashi Yamamoto | Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T. (2013) Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits. Neuron. 78(5):839-854. | |
| CDB0609K | Lrrk2(-) | Nobuyuki Nukina | Imai, Y., Kobayashi, Y., Inoshita, T., Meng, H., Arano, T., Uemura, K., Asano, T., Yoshimi, K., Zhang, C. L., Matsumoto, G., Ohtsuka, T., Kageyama, R., Kiyonari, H., Shioi, G., Nukina, N., Hattori, N. and Takahashi, R. (2015) The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet 11(9): e1005503. | ||
| CDB0610K | CCR2 | contact person Yoshikazu Tamori |
Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H. (2016) Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner. Cell Metab. 24(2):295-310. | ||
| CDB0612K （RBRC09348） |
P13 | KI(lacZ KI) | Masato Kasuga | Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S-I, Itoh H. Novel repressor regulates insulin sensitivity through interaction with Foxo1.: The EMBO JOURNAL. online publication 17 April 2012. | |
| CDB0614K | IL-11(-)：Interleukin(IL)-11 | KO | Toshio Matsumoto | Dong B, Hiasa M, Higa Y, Ohnishi Y, Endo I, Kondo T, Takashi Y, Tsoumpra M, Kainuma R, Sawatsubashi S, Kiyonari H, Shioi G, Sakaue H, Nakashima T, Kato S, Abe M, Fukumoto S, Matsumoto T.(2022）Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Nat Commun 13: 7194. | |
| CDB0618K | ROSA26(HA-YAP-IRES-EGFP) | Knockin | Hiroshi Sasaki | Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H. (2018). Obesity in Yap transgenic mice is associated with TAZ downregulation. Biochem Biophys Res Commun. 505(3):951-957. | |
| CDB0623K （RBRC05284） |
Prominin1 (floxed-lacZ-DTA) | Toru Kondo | Nishide K, Nakatani Y, Kiyonari H, Kondo T. (2009) Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One. 4(8):e6869. doi: 10.1371/journal.pone.0006869. | ||
| CDB0625K | Slc30a8 | Hirotaka Watada | Tamaki, M., Fujitani, Y., Hara, A., Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M., Watanabe, T., Ogihara, T., Fukunaka, A., Shimizu, T., Mita, T., Kanazawa, A., Imaizumi, MO., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Kawauchi, T., Nagamatsu, S., Hirano, T., Kawamori, R. and Watada, H. (2013) The diabetes-susceptible gene SLC30A8/ ZnT8 regulates hepatic insulin clearance. J Clin Invest. 123(10):4513-24. | ||
| CDB0627K （RBRC09330） |
Angpt1 | conditional | Yoshikazu Nakaoka | Lee J, Kim KE, Choi DK, Jang JY, Jung JJ, Kiyonari H, Shioi G, Chang W, Suda T, Mochizuki N, Nakaoka Y, Komuro I, Yoo OJ, Koh GY. Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy. Sci Transl Med. 2013. 18;5(203) | |
| CDB0628K （RBRC09333） | C85492(-):Ago61 | KO(simple knock-out) | Koichi Kato | Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, Khoo KH, Oka S, Kato K. (2013) AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan. Sci Rep. 3:3288. doi: 10.1038/srep03288. | |
| CDB0630K | Crag(loxP)：CRAG/centurin gammma3 | conditional | Shigeru Yanagi | Nagashima, S., K. Takeda, I. Shiiba, M. Higashi, T. Fukuda, T. Tokuyama, N. Matsushita, S. Nagano, T. Araki, M. Kaneko, G. Shioi, R. Inatome and S. Yanagi (2019). Critical role of CRAG, a splicing variant of centaurin-gamma3/AGAP3, in ELK1-dependent SRF activation at PML bodies. Sci Rep 9(1): 20107. | |
| CDB0631K （RBRC09341） |
IL-33 | Hirohisa Saito | Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.(2010) IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A. 107(43): 18581-18586. | ||
| CDB0635K | Pnpla7(loxP)：Pnpla7 | conditional KO | Makoto Murakami | Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y, Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y, Murakami M. (2023) Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell Rep. 42 (2) : 111940 | |
| CDB0637K （RBRC09335） |
Dpysl3 | Yoshio Goshima | Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T. (2012) CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. Dev Neurobiol. 72(11): 1447-1457. | ||
| CDB0642K | Dpysl2：CRMP２ | KO(simple knock-out) | Yoshio Goshima | Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y. (2016) CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development. Genes Cells. 21(9):994-1005. | |
| CDB0649K （RBRC11333） |
LPCAT2(loxP) | Takao Shimizu | Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. (2017) Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. FASEB J. 31(7):2973-2980. | ||
| CDB0653K （RBRC11334） |
LPCAT3(loxP) | conditional | Takao Shimizu | Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. (2015). Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife. 4. doi: 10.7554/eLife.06328. | |
| CDB0658K （RBRC10155） |
Ccdc141(loxP) | Shigeru Yanagi | Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S. (2016) Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep. 17(12):1785-1798. | ||
| CDB0659K | Periostin(-) | KO(simple knock-out) | Yoshiaki Taniyama | Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Abe T, Kiyonari H, Shioi G, Katsuragi N, Ishibashi T, Morishita R, Taniyama Y. (2016) Different roles played by periostin splice variants in retinal neovascularization. Exp Eye Res. 153:133-140. | |
| CDB0660K | DGKdelta-loxP | conditional KO (loxP) | Fumio Sakane | Usuki T, Takato T, Lu Q, Sakai H, Bando K, Kiyonari H, Sakane, F. (2016) Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice. Brain Res. 1648 (Part A), 193–201. | |
| CDB0672K | Gpr176 | tau-lacZ KI | Hitoshi Okamura | Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H. (2016) Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun. 7:10583. doi: 10.1038/ncomms10583. | |
| CDB0674K | PDGFRa-MerCreMer | MerCreMer KI | Shin-Ichi Nishikawa | Ding G, Tanaka Y, Hayashi M, Nishikawa S, Kataoka H. (2013) PDGF receptor alpha+ mesoderm contributes to endothelial and hematopoietic cells in mice. Dev Dyn. 242(3): 254-268. | |
| CDB0678K | DISC１ | KO(simple knock-out) | Kozo Kaibuchi | Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K,Kaibuchi K., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.: Hum Mol Genet. 20(23), 4666-4683, 2011. | |
| CDB0679K | Periostin(-) | KO(simple knock-out) | Yoshiaki Taniyama | Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Abe T, Kiyonari H, Shioi G, Katsuragi N, Ishibashi T, Morishita R, Taniyama Y. (2016) Different roles played by periostin splice variants in retinal neovascularization. Exp Eye Res. 153:133-140. | |
| CDB0683K （RBRC09349） |
PICALM | KO(simple knock-out) | Toshio Watanabe | Suzuki M, Tanaka H, Tanimura A, Tanabe K, Oe N, Rai S, Kon S, Fukumoto, M, Takei K, Abe T, Matsumura I, Kanakura Y, and Watanabe T. (2012) The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS ONE 7(2): e31854. | |
| CDB0693K （RBRC09356） |
Sp7:Osterix | conditional | Riko Nishimura | Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shiho G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T.Osterix Regulates Calcification and Degradation of Chondrogenic Matrices Through Matrix Metalloproteinase (MMP13) Expression in Association with Transcription Factor Runx2 During Endochondral Ossification.J Biol Chem. 2012; 287(40):33179-33190. | |
| CDB0694K | MACS1：AK043126 | KO(simple knock-out) | Toshihiko Shiroishi | Sagai T, Amano T, Maeno A, Kimura T, Nakamoto M, Takehana Y, Naruse K, Okada N, Kiyonari H, Shiroishi T. (2017) Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder. Nat Commun. 8:14300. doi: 10.1038/ncomms14300. | |
| CDB0695K | asrij(ociad1) | conditional | Maneesha Inamdar | Sinha S, Dwivedi TR, Yengkhom R, Bheemsetty VA, Abe T, Kiyonari H, VijayRaghavan K, Inamdar MS. (2019) Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Blood. 133(22):2385-2400. | |
| CDB0702K | Arf1(-) | KO(simple knock-out) | Toshio Watanabe | Hayakawa N, Ogoh H, Sumiyoshi M, Matsui Y, Nishikawa S, Miyamoto K, Maede Y, Kiyonari H, Suzuki M, Watanabe T. (2014) The ADP-ribosylation factor 1 gene is indispensable for mouse embryonic development after implantation. Biochem Biophys Res Commun. 453(4):748-53. | |
| CDB0705K （RBRC09357） |
Spns2 | conditional | Naoki Mochizuki | Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. The Journal of Clinical Investigation.122(4), 1416-1426, 2012. | |
| CDB0706K | DMT1-STOP-RasDA | Yoshiteru Sasaki | Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki JI, Duchen MR, Nam JM, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Sato T, Fujita Y. (2017). Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol. 19(5):530-541. | ||
| CDB0713K | Tshb | luciferase KI | Hiroki Ueda | Tsujino K, Narumi R, Masumoto KH, Susaki EA, Shinohara Y, Abe T, Iigo M, Wada A, Nagano M, Shigeyoshi Y, Ueda HR. Establishment of TSH β real-time monitoring system in mammalian photoperiodism. Genes Cells. 2013; 18(7), 575-588 | |
| CDB0716K | CAMSAP3 | conditional | Masatoshi Takeichi | Toya, M., Kobayashi, S., Kawasaki, M., Shioi, G., Kaneko, M., Ishiuchi, T., Misaki, K., Meng,.W, and Takeichi, M. (2016) CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells. Proc Natl Acad Sci U S A. 113(2):332-7. | |
| CDB0719K | Smoc1 | conditional | Riko Nishimura | Takahata, Y., H. Hagino, A. Kimura, M. Urushizaki, S. Kobayashi, K. Wakamori, C. Fujiwara, E. Nakamura, K. Yu, H. Kiyonari, K. Bando, T. Murakami, T. Komori, K. Hata and R. Nishimura (2021). "Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2." Commun Biol 4(1): 1199. | |
| CDB0740K （RBRC10979, 10980） |
MDGA2：FY29-2 | KI(lacZ KI) | Fumio Matsuzaki | Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM. (2016) Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 91(5):1052-68. | |
| CDB0743K | Nrg1(loxP) | conditional | Shin-ichi Abe | JiDong Zhang, Ko Eto, Asuka Honmyou, Kazuki Nakao, Hiroshi Kiyonari, and Shin-ichi Abe. Neuregulins are essential in spermatogonial proliferation and meiosis initiation in neonatal mouse testis. DEVELOPMENT 2011 in press. | |
| CDB0758K | aquaporin 4(GFP) | EGFP KI | Masato Yasui | Ikeshima-Kataoka H, Abe Y, Abe T, Yasui M. (2013) Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin. Mol Cell Neurosci. 56, 65-75, 2013. | |
| CDB0764K | LMTK3 | Tadashi Yamamoto | Inoue, T., Hoshina, N., Nakazawa, T., Kiyama, Y., Kobayashi, S., Abe, T., Yamamoto, T., Manabe, T. and Yamamoto, T. (2014) LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci 34(17): 5927-37. | ||
| CDB0767K （RBRC02794, 02832, 02857） |
Vps52 | conditional | Kuniya Abe | Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K. Molecular Identification of tw5: Vps52 Promotes Pluripotential Cell Differentiation through Cell-Cell Interactions. Cell Reports 2, 1-12, 2012. | |
| CDB0768K | NDRG2(lacZ) | Kazuhiro Morishita | Nakahata, S., Ichikawa, T., Maneesaay, P., Saito, Y., Nagai, K., Tamura, T., Manachai, N., Yamakawa, N., Hamasaki, M., Kitabayashi, I. Arai, Y., Kanai, Y., Taki, T., Abe, T., Kiyonari, H., Shimoda, K., Ohshima, K., Horii, A., Shima, H., Taniwaki, M., Yamaguchi, R. and Morishita, K. (2014) Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun 5: 3393. | ||
| CDB0773K （RBRC06302） |
NEAT1 | KI(lacZ KI) | Shinichi Nakagawa | Nakagawa S, Naganuma T, Shioi G, Hirose T. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 2011 Apr 4;193(1):31-9. | |
| CDB0774K | Scn4b | KO(simple knock-out) | Nobuyuki Nukina | Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N. (2014). Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 5:5525. doi: 10.1038/ncomms6525. | |
| CDB0777K | TSLP | AFP KI | Susumu Nakae | Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S. (2018). IL-25 enhances T(H)17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells. J Allergy Clin Immunol. pii: S0091-6749(18)30326-9. | |
| CDB0781K | MRCS1：MH8 | KO(simple knock-out) | Toshihiko Shiroishi | Sagai T, Amano T, Maeno A, Kiyonari H, Seo H, Cho SW, Shiroishi T. (2017) SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development. Sci Rep. 7(1):13004. doi: 10.1038/s41598-017-12532-y. | |
| CDB0791K | Phldb2(LL5β) | conditional | Makoto Sato | Xie MJ, Ishikawa Y, Yagi H, Iguchi T, Oka Y, Kuroda K, Iwata K, Kiyonari H, Matsuda S, Matsuzaki, Yuzaki M, Fukazawa Y, Sato M. (2019) PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Sci Rep. 9(1):4305. | |
| CDB0794K （RBRC11344） |
CNOT6(loxP) | KO(simple knockout) conditional KO |
Tadashi Yamamoto Toru Suzuki |
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T. (2020) Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Jan 10:1-14. | |
| CDB0796K | R26R-YapS112A-IG：ROSA:HA-YapSA-IRES-EGFP | Knockin | Hiroshi Sasaki | Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H. (2018). Obesity in Yap transgenic mice is associated with TAZ downregulation. Biochem Biophys Res Commun. 505(3):951-957. | |
| CDB0799K （RBRC09358） |
Top1 | conditional | Tasuku Honjo | Kobayashi M, Sabouri Z, Sabouri S, Kitawaki Y, Pommier Y, Abe T, Kiyonari H, Honjo T. Decrease in topoisomerase I is responsible for activation-induced cytidinedeaminase (AID)-dependent somatic hypermutation. Proc Natl Acad Sci USA.108(48), 19305-19310, 2011. | |
| CDB0800K | Kif26b | conditional | Ryuichi Nishinakamura | Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R. (2015). Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 26(5):1081-1091. | |
| CDB0801K | Sdf2l1(loxP)：Sdf2l1(stromal cell-derived factor 2-like 1) | conditional | Takashi Kadowaki | Sasako, T., Ohsugi, M., Kubota, N., Itoh, S., Okazaki, Y., Terai, A., Kubota, T., Yamashita, S., Nakatsukasa, K., Kamura, T., Iwayama, K., Tokuyama, K., Kiyonari, H., Furuta, Y., Shibahara, J., Fukayama, M., Enooku, K., Okushin, K., Tsutsumi, T., Tateishi, R., Tobe, K., Asahara, H., Koike, K., Kadowaki, T., Ueki, K. (2019). Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun 10, 947. | |
| CDB0802K | Smoc2(-) | KO | Riko Nishimura | Takahata, Y., H. Hagino, A. Kimura, M. Urushizaki, S. Kobayashi, K. Wakamori, C. Fujiwara, E. Nakamura, K. Yu, H. Kiyonari, K. Bando, T. Murakami, T. Komori, K. Hata and R. Nishimura (2021). "Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2." Commun Biol 4(1): 1199. | |
| CDB0803K | claudin1 | conditional KO (loxP) | Akiharu Kubo | Atsugi T, Yokouchi M, Hirano T, Hirabayashi A, Nagai T, Ohyama M, Abe T, Kaneko M, Zouboulis CC, Amagai M, Kubo A. (2019) Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1-Deficient Mice. J Invest Dermatol. pii: S0022-202X(19)33139-2. | |
| CDB0814K | Ras protein activator like 1(RASAL1) | Masao Omata | Takata A, Otsuka M, Kishikawa T, Yamagami M, Ishibashi R, Sekiba K, Suzuki T, Ohno M, Yamashita Y, Abe T, Masuzaki R, Ikenoue T, Koike K. (2017) RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget. 8(39):64840-64852. | ||
| CDB0816K | Eef1d eukaryotic translation elongation factor 1 delta | conditional | Masayuki Matsushita | Kaitsuka T, Kiyonari H, Shiraishi A, Tomizawa K, Matsushita M. (2018). Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. Front Mol Neurosci. 11:358. doi: 10.3389/fnmol.2018.00358. | |
| CDB0818K | claudin-1 | conditional | Sachiko Tsukita | Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S. (2016) Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 113(28):E4061-8. doi: 10.1073/pnas.1525474113. | |
| CDB0831K | Agtr1a | conditional KO (loxP) | Takeshi Tokudome | Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K. (2019) Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Circulation,141(7):571-588,2020 | |
| CDB0832K （RBRC10433） |
Runx2(loxP) | conditional | Yukio Yoneda | Takarada T, Hinoi E, Nakazato R, Ochi H, Xu C, Tsuchikane A, Takeda S, Karsenty G, Abe T, Kiyonari H, Yoneda Y. (2013) An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res. 28(10): 2064-2069. | |
| CDB0833K | ifrd1 | conditional | Yukio Yoneda | Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E. (2015) The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption. J Bone Miner Res. doi: 10.1002/jbmr.2720. | |
| CDB0835K | slc38A1(loxP) | conditional | Takeshi Takarada | Yamada D, Kawabe K, Tosa I, Tsukamoto S, Nakazato R, Kou M, Fujikawa K, Nakamura S, Ono M, Oohashi T, Kaneko M, Go S, Hinoi E, Yoneda Y, Takarada T. (2019) Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Commun Biol. 2:346. | |
| CDB0837K | NEAT2 | KI(lacZ KI) | Shinichi Nakagawa | Nakagawa S, Ip JY, Shioi G, Tripathi V, Zong X, Hirose T, Prasanth KV. Malat1 is not an essential component of nuclear speckles in mice. RNA. online June 20, 2012. | |
| CDB0838K | Pcdh17 | KI(lacZ KI) | Masatoshi Takeichi | Hayashi S, Inoue Y, Kiyonari H, Abe T, Misaki K, Moriguchi H, Tanaka Y, Takeichi M. (2014) Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts. Dev Cell. 30(6):673-87. | |
| CDB0839K | Pcdh19(lacZ) | Masatoshi Takeichi | Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, Takeichi M. (2017) Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice. Sci Rep. 7(1):5801. doi:10.1038/s41598-017-06374-x. | ||
| CDB0840K | Snx5 | GFP KI | contact person Shingo Ichimiya |
Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, Nagaya T, Yamashita K, Kubo T, Kikuchi T, Sato N, Hasegawa T, Kiyonari H, Mukumoto Y, Takano KI, Himi T, Ichimiya S. (2017) Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. J Pathol. doi: 10.1002/path.4951. | |
| CDB0844K | Triobp5 | LacZ KI | Shin-ichiro Kitajiri | Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI. (2019) TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing. JCI Insight. 4(12). pii: 128561. | |
| CDB0849K | Sbno1(loxP) | conditional KO | Yu Katsuyama | Erkhembaatar M, Yamamoto I, Inoguchi F, Taki K, Yamagishi S, Delaney L, Mariko N, Abe T, Kiyonari H , Hanashima C, Naka-Kaneda H, Ihara D, Katsuyama Y.(2022) Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons.Dev Growth Differ. 64(7):379-394. | |
| CDB0850K （RBRC11335） |
Ppp6c | conditional | Hiroshi Shima | Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H. (2015) Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene. 34(35): 4647-55. | |
| CDB0853K | Prmt1 | conditional | Junichiro Mizuguchi | Hata K, Yanase N, Sudo K, Kiyonari H, Mukumoto Y, Mizuguchi J, Yokosuka T. (2016) Differential regulation of T-cell dependent and T-cell independent antibody responses through arginine methyltransferase PRMT1 in vivo. FEBS Lett. 590(8):1200-10. doi: 10.1002/1873-3468.12161. | |
| CDB0862K | MUK (DLK/Map3k12) | KI(ires-β geo) | Shu-ichi Hirai | Hirai, S., Cui, DF., Miyata, T., Ogawa M., Kiyonari, H., Suda, Y., Aizawa, S., Banba, Y. and Ohno, S. (2006). The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex. The Journal of Neuroscience 26, 11992-12002. | |
| CDB0877K | GATA1IRESMCM | IRES Mer-Cre-Mer KI | Yosuke Tanaka | Tanaka Y, Sanchez V, Takata N, Yokomizo T, Yamanaka Y, Kataoka H, Hoppe PS, Schroeder T, Nishikawa SI. (2014) Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts. Cell Rep. 8(1): 31-39. | |
| CDB0884K （RBRC11338） |
Arf4(loxP) | conditional | Teiichi Furuichi | Nobutake Hosoi, Koji Shibasaki, Mayu Hosono, Ayumu Konno, Yo Shinoda, Hiroshi Kiyonari, Kenichi Inoue, Shin-ichi Muramatsu, Yasuki Ishizaki, Hirokazu Hirai, Teiichi Furuichi and Tetsushi Sadakata. (2019) Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments. Journal of Neuroscience 39(32):6339-6353. | |
| CDB0885K （RBRC11339） |
Arf5(loxP) | conditional | |||
| CDB0895K | TSK(loxP) | conditional | Kunimasa Ohta | Ito, N., Riyadh, M. A., Ahmad, S. A. I., Hattori, S., Kanemura, Y., Kiyonari, H., Abe, T., Furuta, Y., Shinmyo, Y., Kaneko, N., Hirota, Y., Lupo, G., Hatakeyama, J., Abdulhaleem, M. F., Anam, M. B., Yamaguchi, M., Takeo, T., Takebayashi, H., Takebayashi, M., Oike, Y., Nakagata, N., Shimamura, K., Holtzman, M. J., Takahashi, Y., Guillemot, F., Miyakawa, T., Sawamoto, K., & Ohta, K. (2021). Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Sci Transl Med, 13(587). | |
| CDB0907K | sema7a(loxP) | conditional KO (loxP) | Hitoshi Sakano | Inoue, N., Nishizumi, H., Naritsuka, H., Kiyonari, H., Sakano, H. (2018) Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation. Nat. Commun. Nature 9, 1842 | |
| CDB0908K | Plxnc1(loxP)：plexinC1 | conditional KO (loxP) | Hitoshi Sakano | Inoue, N., Nishizumi, H., Naritsuka, H., Kiyonari, H., Sakano, H. (2018) Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation. Nat. Commun. Nature 9, 1842 | |
| CDB0910K | ROSA-Etv2 | CAG-floxSTOP-Etv2-frtGFP | Hiroshi Kataoka | Hayashi M, Pluchinotta M, Momiyama A, Tanaka Y, Nishikawa S, Kataoka H. Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp Hematol. 2012 Sep;40(9):738-750. | |
| CDB0913K | Gm129 | Conditional KO flox | Toru Takumi | Goriki, A., Hatanaka, F., Myung, J., Kim, JK., Yoritaka, T., Tanoue, S., Abe, T., Kiyonari, H., Fujimoto, K., Kato, Y., Todo, T., Matsubara, A., Forger, D. and Takumi, T. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12(4):e1001839. doi: 10.1371/journal.pbio.1001839. | |
| CDB0916K | CNOT1 | KO(simple knockout), conditional KO | Toru Suzuki Tadashi Yamamoto |
Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, Yasuhide Furuta, Keiji Kuba, and Tadashi Yamamoto. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. (2020) Life Science Alliance, in press. | |
| CDB0920K | Pcdh9(-)：PCDH9(Protocadherin9) | KO | Shinji Hirano | Uemura M, Furuse T, Yamada I, Kushida T, Abe T, Imai K, Nagao S, Kudoh M, Yoshizawa K, Tamura M, Kiyonari H, Wakana S, Hirano S. (2022). Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour. Sci Rep 12, 11933. | |
| CDB0923K | Prdm1(EGFP) | GFP KI | Mitinori Saitou | Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M. (2015) Quantitative Dynamics of Chromatin Remodeling during Germ Cell pecification from Mouse Embryonic Stem Cells. Cell Stem Cell. 16(5):517-32. | |
| CDB0927K | Fhod3(loxP) | conditional | Ryu Takeya | Ushijima T, Fujimoto N, Matsuyama S, Kan-O M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H. (2018) The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. J Biol Chem. 293(1):148-162. | |
| CDB0933K | RhoJ-flox | Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, Uemura A, Koh GY. (2014) Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 25(1): 102-117. | |||
| CDB0938K | Lats1 | KO(simple knock-out) | Norikazu Yabuta | Mukai, S., Yabuta, N., Yoshida, K., Okamoto, A., Miura, D., Furuta, Y., Abe, T. and Nojima H. (2015) Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B. Sci Rep 5:16173. doi: 10.1038/srep16173. | |
| CDB0939K | Ptger2(loxP) | Shuh Narumiya | Aoki T, Frȍsen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J, Narumiya S. (2017) Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal. 10(465). pii: eaah6037. doi: 10.1126/scisignal.aah6037 | ||
| CDB0941K | AS3_9(-) | KO(simple knock-out) | Norihiro Okada | Nishihara H, Kobayashi N, Kimura-Yoshida C, Yan K, Bormuth O, Ding Q, Nakanishi A, Sasaki T, Hirakawa M, Sumiyama K, Furuta Y, Tarabykin V, Matsuo I, Okada N. (2016) Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet. 12(10):e1006380. | |
| CDB0944K | Psmd10(loxP) | conditional | Masatoshi Kudo | Sakurai T, Higashitsuji H, Kashida H, Watanabe T, Komeda Y, Nagai T, Hagiwara S, Kitano M, Nishida N, Abe T, Kiyonari H, Itoh K, Fujita J, Kudo M. (2017) The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3. Oncotarget. 8(15):24762-24776. | |
| CDB0945K | Cldn-7(loxP) | Sachiko Tsukita | Tanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A. and Tsukita, S. (2015) Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice. Gut 64(10): 1529-38. | ||
| CDB0949K | Optn(-)：optineurin | KO | Hideshi Kawakami | Kurashige, T., Kuramochi, M., Ohsawa, R., Yamashita, Y., Shioi, G., Morino, H., Kamada, M., Ayaki, T., Ito, H., Sotomaru, Y., Maruyama, H., & Kawakami, H. (2021). Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. Neurobiol Dis, 148, 105215. | |
| CDB0952K | Evi3(-) | Masaki Yasukawa | Ohkubo, N., Matsubara, E., Yamanouchi, J., Akazawa, R., Aoto, M., Suzuki, Y., Sakai, I., Abe, T., Kiyonari, H., Matsuda, S., Yasukawa, M. and Mitsuda, N. (2014) Abnormal behaviors and developmental disorder of hippocampus in zinc finger protein 521 (ZFP521) mutant mice. PLoS One 9(3): e92848. | ||
| CDB0954K | Zfhx4 | conditional | Riko Nishimura | Eriko Nakamura, Kenji Hata, Yoshifumi Takahata, Hiroshi Kurosaka, Makoto Abe, Takaya Abe, Miho Kihara, Toshihisa Komori, Sachi Kobayashi, Tomohiko Murakami, Toshihiro Inubushi, Takashi Yamashiro, Shiori Yamamoto, Haruhiko Akiyama, Makoto Kawaguchi, Nobuo Sakata & Riko Nishimura (2021) Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol 4, 1258. | |
| CDB0955K | USP40(loxP)：USP40(ubiquitin specific protease 40) | conditional KO | Kunimasa Yan | Takahashi S, Fukuhara D, Kimura T, Fukutomi T, Tanaka E, Mikami N, Hada I, Takematsu H, Nishibori Y, Akimoto Y, Kiyonari H, Abe T, Huber O, Yan K. (2022) USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage. Biochem Biophys Res Commun. 614:198-206. | |
| CDB0956K | Faf2 | UBXD8 (loxP), conditional KO | Toyoshi Fujimoto | Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. (2015). Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One. 10(5):e0127114. | |
| CDB0960K | KIAA1462 | KO(simple knock-out) | Mikio Furuse | Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI. (2017) Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 37(9):1667-1673. | |
| CDB0970K | Runx2(loxP)：Runx2(runt-related transcription factor 2) | conditional KO | Yasushi Fujio | Tomimatsu M, Matsumoto K, Ashizuka M, Kumagai S, Tanaka S, Nakae T, Yokota K, Kominami S, Kajiura R, Okuzaki D, Motooka D, Shiraishi A, Abe T, Matsuda H, Okada Y, Maeda M, Seno S, Obana M, Fujio Y.(2022) Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling. Sci Rep 12: 16656 | |
| CDB0977K | LPAR6 | conditional KO (loxP) | Satoshi Ishii | Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M. (2016) Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int Immunol. 28(6):283-92. | |
| CDB0982K | exophilin5(Exph5) | KO | Tetsuro Izumi | Okunishi, K., Wang, H., Suzukawa, M., Ishizaki, R., Kobayashi, E., Kihara, M., Abe, T., Miyazaki, J. I., Horie, M., Saito, A., Saito, H., Nakae, S., & Izumi, T. (2020). Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. J Clin Invest, 130(7), 3919-3935. | |
| CDB0983K （RBRC09351） |
Rad21L(-)：Gm14160 | KO(simple knock-out) | Yoshinori Watanabe | Ishiguro KI, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y. (2014) Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 28(6): 594-607. | |
| CDB0985K | Prdm14(-) | Mitinori Saitou | Yamaji M, Seki Y, Kurimoto K, Yabuta Y, Yuasa M, Shigeta M, Yamanaka K, Ohinata Y, Saitou M. (2008) Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet. 40(8): 1016-1022. | ||
| CDB0998K | gpr143 | Yoshio Goshima | Fukuda, N., Naito, S., Masukawa, D., Kaneda, M., Miyamoto, H., Abe, T., Yamashita, Y., Endo, I., Nakamura, F. and Goshima, Y. (2015) Expression of ocular albinism 1 (OA1), 3, 4- dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal organs. Brain Res 1602: 62-74 | ||
| CDB1000K | cldn14 | KO(simple knock-out) | Takahiro Kubota | Shiraiwa Y, Daikoku E, Saito M, Yamashita Y, Abe T, Ono F, Kubota T. (2017) Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice. Auris Nasus Larynx. pii: S0385-8146(17)30052-4. | |
| CDB1003K | Epo(CreERT2): EPO/erythropoietin(CreERT2ノックイン) | KI | Motoko Yanagita | Kaneko K, Sato Y, Uchino E, Toriu N, Shigeta M, Kiyonari H, Endo S, Fukuma S, Yanagita M. (2022) Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors. Kidney Int. 102, 280–292. | |
| CDB1008K | tau-YFP | Olfr1019 Venus KO/KI | Hitoshi Sakano | Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. (2017) Immobility responses are induced by photoactivation of single glomerular species esponsive to fox odour TMT. Nat Commun. 8:16011. doi: 10.1038/ncomms16011. | |
| CDB1012K | IL31RA(lacZ) | KI(lacZ KI) | Saburo Saito | Saito S, Aoki A, Arai I, Takaishi S, Ito H, Akiyama N, Kiyonari H. (2017) Regulation of Th2 responses by different cell types expressing the interleukin‑31 receptor. Allergy, Asthma & Clinical Immunology. DOI 10.1186/s13223-017-0194-9 | |
| CDB1016K | Pin1 | conditional | Tomoichiro Asano | Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T. (2015) Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit. J Biol Chem. 290(40):24255-66. | |
| CDB1019K | Nrd1(loxP) | conditional | Eiichiro Nishi | Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E. (2016) Nardilysin Is Required for Maintaining Pancreatic β-Cell Function. Diabetes. 65(10):3015-27. | |
| CDB1022K | SASPase/ASPRV1 | KI | Takeshi Matsui | Matsui, T., Kadono-Maekubo, N., Suzuki, Y., Furuichi, Y., Shiraga, K., Sasaki, H., Ishida, A., Takahashi, S., Okada, T., Toyooka, K., Sharif, J., Abe, T., Kiyonari, H., Tominaga, M., Miyawaki, A., & Amagai, M. (2021). A unique mode of keratinocyte death requires intracellular acidification. Proc Natl Acad Sci U S A, 118 (17) e2020722118 | |
| CDB1024K | Sema6A | conditional KO (loxP) | Takahiko Kawasaki | Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata. (2019) Semaphorin 6A–Plexin A2/A4 interactions with radial glia regulate migration termination of superficial layer cortical neurons. iScience. 21:359-374. | |
| CDB1026K | Tgf | conditional | Tomoichiro Asano | Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T. (2017) Trk-fused gene(TFG) regulates pancreatic β cell mass and insulin secretory activity. Sci Rep. 7(1):13026. doi: 10.1038/s41598-017-13432-x. | |
| CDB1027K | Arf1(loxP) | conditional | Toshio Watanabe | Sumiyoshi, M., Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda (2021). Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation. J Immunol 206(2): 366-375. | |
| CDB1028K （RBRC10095） |
IRF3 | conditional | Tadatsugu Taniguchi | Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T. (2018) Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A. 115(20):5253-5258. | |
| CDB1030K | Ccl21a(Tomato) | tdTomato KI | Yousuke Takahama | Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.(2017) Essential role of CCL21 in establishment of central selftolerance in T cells. J Exp Med. 214(7):1925-1935. | |
| CDB1032K | ヒトCaSR activation mutation C129S(t757a) | Casr(hCasr c129s) KI | Toshio Matsumoto | Dong, B., Endo, I., Ohnishi, Y., Kondo, T., Hasegawa, T., Amizuka, N., Kiyonari, H., Shioi, G., Abe, M., Fukumoto, S. and Matsumoto, T. (2015) Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH). J Bone Miner Res. 2015 May 12. doi: 10.1002/jbmr.2551. | |
| CDB1033K | AF10 | conditional KO, Mllt10, exon 16 floxed, loxP (phage P1 loxP) | Issay Kitabayashi | Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D.(2017). Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep. 2017 Sep 20;7(1):11922 | |
| CDB1054K | ヒトCaSR activation mutation A843E(c2900a) | Casr(hCasr A843E) KI | Toshio Matsumoto | Dong, B., Endo, I., Ohnishi, Y., Kondo, T., Hasegawa, T., Amizuka, N., Kiyonari, H., Shioi, G., Abe, M., Fukumoto, S. and Matsumoto, T. (2015) Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH). J Bone Miner Res. 2015 May 12. doi: 10.1002/jbmr.2551. | |
| CDB1060K | Period2 | Base substitutions | Hitoshi Okamura | Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, Okamura H. (2019) Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity. Nat Commun. 10(1):2563. | |
| CDB1061K | Camsap1 | KO | Masatoshi Takeichi Wenxiang Meng |
Zhou, Z., Xu, H., Li, Y., Yang, M., Zhang, R., Shiraishi, A., Kiyonari, H., Liang, X., Huang, X., Wang, Y., et al. (2020). CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity. Proc Natl Acad Sci U S A 117, 22193-22203. | |
| CDB1062K | Camsap2：Camsap1|1 | KO(simple knock-out) | Masatoshi Takeichi | Varisa Pongrakhananon, Hiroko Saito, Sylvain Hiver, Takaya Abe, Go Shioi, Wenxiang Meng, and Masatoshi Takeichi. (2018) CAMSAP3 maintains neuronal polarity through regulation of microtubule stability. PNAS 115: 9750-9755 | |
| CDB1066K | Ola1 knockout | KO | Natsuko Chiba | Yoshino Y, Ogoh H, Iichi Y, Sasaki T, Yoshida T, Ichimura S, Nakayama M, Xi W, Fujita H, Kikuchi M, Fang Z, Li X, Abe T, Futakuchi M, Nakamura Y, Watanabe T, Chiba N (2024) Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification. Biochim Biophys Acta Mol Basis Dis. 1870(5):167138. | |
| CDB1070K | early Bcell factor 3 | conditional KO | Atsuko Sehara | Kuriki, M., Sato, F., Arai, H.N., Sogabe, M., Kaneko, M., Kiyonari, H., Kawakami, K., Yoshimoto, Y., Shukunami, C., and Sehara-Fujisawa, A. (2020). Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development 147. | |
| CDB1078K | Cd47(loxP) | conditional KO | Takashi Matozaki | Saito, Y., Respatika, D., Komori, S., Washio, K., Nishimura, T., Kotani, T., Murata, Y., Okazawa, H., Ohnishi, H., Kaneko, Y., Yui, K., Yasutomo, K., Nishigori, C., Nojima, Y., Matozaki, T. (2017). SIRPα(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. Proc Natl Acad Sci USA 114, 201711345–E10160. | |
| CDB1079K （RBRC09342） |
Kif14 | KO(simple knock-out) | Toshiaki Sakisaka | Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T. (2013) Kif14 mutation causes severe brain malformation and hypomyelination. PLoS One. 8(1):e53490. doi:10.1371/journal.pone.0053490. | |
| CDB1091K | CAPS1(CADPS) | Yukio Kawahara | Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y. (2016) CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Reports 17(8): 2004-2014. | ||
| CDB1100K | Myrip(-) | Tetsuro Izumi | Fan F, Matsunaga K, Wang H, Ishizaki R, Kobayashi E, Kiyonari H, Mukumoto Y, Okunishi K, Izumi T. (2017) Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. Elife. 6. pii: e26174. doi: 10.7554/eLife.26174. PubMed PMID: 28673385; PubMed Central PMCID: PMC5496739. | ||
| CDB1102K | Fam132a(-) | KO(simple knock-out) | Noriyuki Ouchi | Ogawa H, Ohashi K, Ito M, Shibata R, Kanemura N, Yuasa D, Kambara T, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Otaka N, Kawanishi H, Yamaguchi S, Enomoto T, Abe T, Kaneko M, Takefuji M, Murohara T, Ouchi N.（2019）Adipolin/CTRP12 protects against pathological vascular remodeling through suppression of smooth muscle cell growth and macrophage inflammatory response. Cardiovascular Research, pii: cvz074. | |
| CDB1106K | zfp828 | KO | Kozo Tanaka | Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata KI, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K.(2022) Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype. Brain Commun 4(5):fcac220. | |
| CDB1107K | Mir335(-) | KO(simple knock-out) | Atsuko Sehara | Hiramuki Y, Sato Y, Furuta Y, Surani M. A, Sehara-Fujisawa A. (2015). Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration. PLoS ONE 10(6): e0130436. | |
| CDB1127K | Ptprz(Pro1998end):Ptprz(PTP-D1 stop変異) | conditional KO (loxP) | Masaharu Noda | Tanga N, Kuboyama K, Kishimoto A, Kihara M, Kiyonari H, Watanabe T, Fujikawa A, Noda M. (2019) Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ). PLoS One. 14(6):e0217880. | |
| CDB1131K | Ccl21a-Cre | KI | Yousuke Takahama | Ohigashi I, White AJ, Yang MT, Fujimori S, Tanaka Y, Jacques A, Kiyonari H, Matsushita Y, Turan S, Kelly MC, Anderson G, Takahama Y. (2024) Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium. Elife.12:RP92552. | |
| CDB1144K | Gpsm2(loxP):modified LGN-venusC | KO | Fumio Matsuzaki | Fujita I, Shitamukai A, Kusumoto F, Suetsugu T, Mase S, Omori A, Kato K, Abe T, Shioi G, Konno D, Matsuzaki F. (2020) Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development. Nat. Cell Biol. 22, 26-37. | |
| CDB1149K | Pcdhγ A12/C3 | KO | Takeshi Yagi | Kobayashi H, Takemoto K, Sanbo M, Hirabayashi M, Hirabayashi T, Hirayama T, Kiyonari H, Abe T, Yagi T. (2023) Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience 26: 105766. | |
| CDB1170K | Klotho | conditional | Kazushige Sakaguchi | Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro-O M, Furuta Y, Sakaguchi K. (2017) Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 7:40534. doi:10.1038/srep40534. | |
| CDB1182K | HchwR-Venus | Olfr1019 ires-ChRWR-Venus KI | Hitoshi Sakano | Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. (2017) Immobility responses are induced by photoactivation of single glomerular species esponsive to fox odour TMT. Nat Commun. 8:16011. doi: 10.1038/ncomms16011. | |
| CDB1185K | miR-199a-2 | KO(simple knock-out) | Kinichi Nakashima | Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M., Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. and Nakashima, K. (2015) miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes. Cell Rep 12(11): 1887-901. | |
| CDB1190K | FGFR4 | conditional | Kazushige Sakaguchi | Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro-O M, Furuta Y, Sakaguchi K. (2017) Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 7:40534. doi:10.1038/srep40534. | |
| CDB1193K | R26R(H2B-FLAG) | ROSA26(H2B-FLAG)KI | Shinichi Nakagawa | Mito M, Kadota M, Tanaka K, Furuta Y, Abe K, Iwasaki S, Nakagawa S. (2018) Cell Type-Specific Survey of Epigenetic Modifications by Tandem Chromatin Immunoprecipitation Sequencing. Sci Rep. 8(1):1143. | |
| CDB1201K | R26-STOP-SHARPIN | ROSA26 conditional KI | Kazuhiro Iwai, Katsuhiro Sasaki | Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K. (2019) Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 10(1):3878. | |
| CDB1212K | Ndc80 | KO | Tomoya Kitajima | Yoshida, S., S. Nishiyama, L. Lister, S. Hashimoto, T. Mishina, A. Courtois, H. Kyogoku, T. Abe, A. Shiraishi, M. Choudhary, Y. Nakaoka, M. Herbert and T. S. Kitajima (2020). "Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes." Nat Commun 11(1): 2652. | |
| CDB1218K （RBRC09630） |
Haus6 | conditional | Gohta Goshima Sadanori Watanabe |
Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Cell Rep. 15(1):54-60. | |
| CDB1228K | Adam19(loxP,P2A Venus) | conditional KO (loxP) | Atsuko Sehara | Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A. (2019) Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 29(3):603-616 | |
| CDB1231K | IL-11(loxP)(interleukin 11), Gene ID:16156 | conditional KO | Toshio Matsumoto | Dong B, Hiasa M, Higa Y, Ohnishi Y, Endo I, Kondo T, Takashi Y, Tsoumpra M, Kainuma R, Sawatsubashi S, Kiyonari H, Shioi G, Sakaue H, Nakashima T, Kato S, Abe M, Fukumoto S, Matsumoto T.(2022）Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Nat Commun 13: 7194. | |
| CDB1232K | nphp3 | point mutations | Takahiko Yokoyama | Nakajima Y, Kiyonari H, Mukumoto Y, Yokoyama T. (2018) The Inv compartment of renal cilia is an intraciliary signal activating center to phosphorylate ANKS6. Kidney Int. pii: S0085-2538(17)30852-9. | |
| CDB1236K | FOXK1(loxP) | conditional KO | Keiichi Nakayama | Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI. (2023) FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Cell Rep 42 (5) : 112530 | |
| CDB1237K | 1110012J17Rik | conditional | Atsushi Suzuki | Satake T, Yamashita K, Hayashi K, Miyatake S, Tamura-Nakano M, Doi H, Furuta Y, Shioi G, Miura E, Takeo YH, Yoshida K, Yahikozawa H, Matsumoto N, Yuzaki M, Suzuki A. (2017) MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. EMBO J. pii: e201695630. doi: 10.15252/embj.201695630. | |
| CDB1255K | beta5t(G49S-pA) | SNP KI | Yousuke Takahama | Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y. (2017) A human SMB11 variant affects thymoproteasome processing and CD8+ T cell production. JCI Insight. 2(10). pii: 93664. doi:10.1172/jci.insight.93664. | |
| CDB1256K | Fam59b(loxP): (GI: 268832228) | conditional KO (loxP) | Hiroaki Konishi | Nishino T, Tamada K, Maeda A, Abe T, Kiyonari H, Funahashi Y, Kaibuchi K, Takumi T, Konishi H. (2019) Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Mol Brain. 12(1):94. | |
| CDB1257K | Fam59a(loxP): (GI:134288887) | conditional KO | Hiroaki Konishi | Nishino T, Abe T, Kaneko M, Yokohira M, Yamakawa K, Imaida K, Konishi H.(2022) GAREM1 is involved in controlling body mass in mice and humans. Biochem Biophys.Res Commun.628:91-97. | |
| CDB1274K | Pithd1(Tomato) | KI | Izumi Ohigashi | Kondo H, Matsumura T, Kaneko M, Inoue K, Kosako H, Ikawa M, Takahama Y, Ohigashi I. PITHD1 is a proteasome-interacting protein essential for male fertilization. Journal of Biological Chemistry. 2020, 295(6):1658-1672. | |
| CDB1301K | Rnu11(loxP)：U11 spliceosomal RNA(Rnu11) | conditional KO (loxP) | Tadatsugu Taniguchi | Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T. (2019) Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23653-23661. | |
| CDB1302K | Hey1 | conditional | Osamu Nakagawa | Watanabe, Y., D. Seya, D. Ihara, S. Ishii, T. Uemoto, A. Kubo, Y. Arai, Y. Isomoto, A. Nakano, T. Abe, M. Shigeta, T. Kawamura, Y. Saito, T. Ogura and O. Nakagawa (2020). "Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription." J Biol Chem 295(51): 17632-17645. | |
| CDB1303K | Dmrta1-KO(CRISPR) | KO(CRISPR) | Fumio Matsuzaki | Daijiro Konno, Chiaki Kishida, Kazumitsu Maehara, Yasuyuki Ohkawa, Hiroshi Kiyonari, Seiji Okada, Fumio Matsuzaki. (2019) Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes. Development. 146(15). pii: dev174243. | |
| CDB1313K | Smad3 | conditional | Takeshi Miyamoto | Umezu, T., S. Nakamura, Y. Sato, T. Kobayashi, E. Ito, T. Abe, M. Kaneko, M. Nomura, A. Yoshimura, A. Oya, M. Matsumoto, M. Nakamura, A. Kanaji and T. Miyamoto (2021). "Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice." Biochem Biophys Res Commun 582: 111-117. | |
| CDB1320K | ROSA26-STOP-Myd88_L252P-ires-eGFP-pA | conditional Tg | Kazuhiro Iwai | Jo, T., M. Nishikori, Y. Kogure, H. Arima, K. Sasaki, Y. Sasaki, T. Nakagawa, F. Iwai, S. Momose, A. Shiraishi, H. Kiyonari, N. Kagaya, T. Onuki, K. Shin-Ya, M. Yoshida, K. Kataoka, S. Ogawa, K. Iwai and A. Takaori-Kondo (2020). LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells. Blood 136(6): 684-697. | |
| CDB1329K | KAT5(loxP) | cconditional KO | Hiroshi Ito | A. Hishikawa, K. Hayashi, T. Abe, M. Kaneko, H. Yokoi, T. Azegami, M. Nakamura, N. Yoshimoto, T. Kanda, Y. Sakamaki and H. Itoh (2019). Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes. Cell Rep 26(5): 1318-1332 e1314. | |
| CDB1353K | DCTN1 | point mutation | Yoshio Tsuboi | Deshimaru, M., T. Mishima, T. Watanabe, K. Kubota, M. Hosoi, M. Kinoshita-Kawada, J. Yuasa-Kawada, M. Ikeda, M. Mori, Y. Murata, T. Abe, M. Enjoji, H. Kiyonari, S. Kodama, S. Fujioka, K. Iwasaki and Y. Tsuboi (2021). "Behavioral profile in a Dctn1(G71A) knock-in mouse model of Perry disease." Neurosci Lett 764: 136234. | |
| CDB1355K | HAUS6 | KO | Gohta Goshima | Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Cell Rep. 15(1):54-60. | |
| CDB1373K | Nppb | KI | Ryuji Okamoto | Okamoto R, Hashizume R, Suzuki N, Ito R, Tokuhara T, Fujiwara H, Ye Z, Ito H, Abe T, Dohi K. (2022) Serum-Inducted Expression of Brain Natriuretic Peptide Contributes to Its Increase in Patients with HFpEF. Int J Mol Sci. 23(6),2991. |
RandomTransgenesis
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| CDB Acc.No. | Line Name | Corresponding Researcher | Original paper | Reference | Remarks from researchers |
|---|---|---|---|---|---|
| CDB0001T | K1-1 | Shinichi Aizawa | Kurokawa D, Takasaki N, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development 131, 3307ー3317. 2004 | A transgenic line. Transgene: Otx2 BAC DNA encompassing -170kb to -30kb is conjugated with Otx2 -1.8kb 5' region adjacent to the translation start site and LacZ-pA (BAC#1, Fig.1 in original paper). | |
| CDB0003T | K44(K43-49) | Shinichi Aizawa | Kurokawa D, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. (2004) | A transgenic line. Transgene: LacZ-pA is inserted at the translational start site of Otx2 BAC DNA encompassing -50kb to +120kb.(Fig. 5Ba in original paper) | |
| CDB0005T | K27 | Shinichi Aizawa | Kurokawa D, Takasaki N, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development 131, 3307ー3317. 2004 | A transgenic line. Transgene: Otx2 AN enhancer that directs the expression in anterior neuroectodermOtx2 AN enhancer (15 kb XhoI fragment at -92kb to -77kb) that directs the expression in anterior neuroectoderm (Fig2Ba-f in original paper) | |
| CDB0022T | K170 | Shinichi Aizawa | Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 | A transgenic line. Transgene: Skate Otx2 AN enhancer that directs the expression in anterior neuroectoderm (Fig. 5A,B in Original paper ) | |
| CDB0023T | K177 | Shinichi Aizawa | Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 | A transgenic line. Transgene: Skate Otx2 FM enhancer that directs the expression in forebrain and midbrain (Fig. 5C, D in original paper) | |
| CDB0024T | K178 | Shinichi Aizawa | Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 | A transgenic line. Transgene: Coelacanth Otx2 AN enhancer that directs the expression in anterior neuroectoderm (Fig. 5E,F in Original paper ) | |
| CDB0025T | K179 | Shinichi Aizawa | Kurokawa D, Sakurai Y, Inoue A, Nakayama R, Takasaki N, Suda Y, Miyake T, Amemiya CT, Aizawa S. Evolutionary constraint on Otx2 neuroectoderm enhancer-deep conserved from skate to mouse and unique divergence in Teleost. Proc. Natl. Acad. Sci. USA. 103, 19350-19355 | A transgenic line. Transgene: Coelacanth Otx2 FM enhancer that directs the expression in forebrain and midbrain (Fig. 5G,H in Original paper ) | |
| CDB0027T | K33 | Shinichi Aizawa | Kurokawa D,Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. 2004 | A transgenic line. Transgene: Otx2 FM enhancer (10 kb XhoI-ClaI fragment at the -77kb to -68kb) that directs the expression in forebrain and midbrain (Fig. 1Ba-f in original paper) | |
| CDB0033T | K43 | Shinichi Aizawa | Kurokawa D,Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131, 3319ー3331. 2005 | A transgenic line. Transgene: Otx2 FM2 enhancer (10 kb MluI-NotI fragment at +106kb to +116kb 3’ downstream) that directs the expression in forebrain and midbrain (Fig. 4Bd-i in original paper) | |
| CDB0034T | 1.8Otx2-H2B-mCherry | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | ||
| CDB0035T | Cer1-H2BmCherry | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | ||
| CDB0036T | Lefty1-H2BmCherry | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | ||
| CDB0037T | 1.8Otx2-CreERTM | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | ||
| CDB0038T | Dkk1-CreERTM | Shinichi Aizawa | Hoshino, H., Shioi, G. and Aizawa, S. (2015) 'AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression', Dev Biol 402(2): 175-91. | ||
| CDB0201T-1 | pCAGGS-kik-1 | Shinichi Aizawa | Kurotaki, Y., Hatta, K., Nakao, K., Nebeshima, Y., and Fujimori, T. Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science 316(5825):719-723(2007)" | Expression level is higher than CAG-KikGR-2 | |
| CDB0201T-2 | pCAGGS-kik-2 | Shinichi Aizawa | Kurotaki Y, Hatta K, Nakao K, Nabeshima Y, Fujimori T. Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science. 2007 May 4;316(5825):719-23. | Expression level is lower than CAG-KikGR-1 | |
| CDB0404T | CAG-MerCreMer | Shin-Ichi Nishikawa | Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S. (2009) Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 129(10): 2386-2395. | ||
| CDB0406T | TBP-2 | Junji Yodoi | Okuyama H, Yoshida T, Son A, Oka S, Wang D, Nakayama R, Masutani H, Nakamura H, Nabeshima Y, Yodoi J. Thioredoxin binding protein 2 modulates natural killer T cell-dependent innate immunity in the liver: possible link to lipid metabolism. Antioxid Redox Signal. 11(10):2585-93. 2009 | Line C was analyzed. | |
| CDB0407T | stella-EGFP | Mitinori Saitou | Payer, B., Chuva de Sousa Lopes, S. M., Barton, S. C., Lee, C., Saitou, M., and Surani, M. A. (2006). Generation of stella-GFP transgenic mice, a novel tool to study germ cell development. Genesis, 44, 75-83. Seki, Y., Yamaji, M., Yabuta, Y., Sano, M., Shigeta, M., Matsui, Y., Saga, Y., Tachibana, M., Shinkai, Y., and Saitou, M. (2007). Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development, 134, 2627-2638." | EGFP is expressd under the control of stella regulatory elements. The original stella-EGFP BAC is generated in the lab of Prof. M. Azim Surani. | |
| CDB0409T | Dct Hes1 | Shin-Ichi Nishikawa | Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa SI. (2006) Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173, 333-339. | A line that expresses HES1 under Dct promotor that is specific to melanocyte. It can be used for constitutively activating Notch signal in malnocyte lineage. | |
| CDB0410T | Dct Hes 1 dn | Shin-Ichi Nishikawa | Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa SI. (2006) Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173, 333-339. | A line that expresses dominant negative form of HES1 under Dct promoter that is specific to melanocyte. It is used for constitutively inhibiting Notch signal in melanocyte lineage. | |
| CDB0413T | Blimp1-mEGFP | Michinori Saitou | Ohinata, Y., Payer, B., O’Carroll, D., Ancelin, K., Ono, Y., Sano, M., Barton, S. C., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., *Saitou, M., and *Surani, M. A. (2005). Blimp1 is a critical determinant of the germ cell lineage in mice. Nature, 436, 207-213. | membrane-targeted EGFP is expressed under the control of Blimp1 | |
| CDB0415T-34 （RBRC02592, 09237） |
p21-p-luc | Eiji Hara | Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., David J. Mann, Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K., and Hara, E. Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals. Proc. Natl. Acad. Sci. USA. 104/38, 15034-15039, 2007 | fire fly luciferase is expressed under the control of the p21 gene promoter | |
| CDB0416T-53 （RBRC05271, 09236） |
p16-luc | Eiji Hara | Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N. & Hara, E. Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53. J. Cell Biol. 186: 393-407 (2009)" | Firefly luciferase is expressed under the control of the human p16INK4a gene promoter. | |
| CDB0419T-2 | CAG-CAT-PGrn | Shin-ichi Osada | Kato M, Hasunuma N, Manabe M, Nakayama R, Takeda J, Itami S, Taira M, Osada S-I., Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth.:Journal of Dermatological Science.53, 222-243, 2009. | Human progranulin can be expressed in a tissue-specific manner, when cross-bred with a conditional Cre transgenic mouse | |
| CDB0425T | misCreERTM | Shin-ichi Abe | JiDong Zhang, Ko Eto, Asuka Honmyou, Kazuki Nakao, Hiroshi Kiyonari, and Shin-ichi Abe. Neuregulins are essential in spermatogonial proliferation and meiosis initiation in neonatal mouse testis. DEVELOPMENT 2011 in press. | Cre expression is induced by administration of tamoxifen in Sertoli cells driven by MIS promoter | |
| CDB0437T | PLCD1 | Kiyoko Fukami | Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K.Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun. 2012 Jul 17;3:963. doi: 10.1038/ncomms1960. | PLCD1 is expressed under control of FOXN1 promoter. | |
| CDB0446T | aP2-Fcor | Masato Kasuga | Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S-I, Itoh H. Novel repressor regulates insulin sensitivity through interaction with Foxo1.: The EMBO JOURNAL. online publication 17 April 2012. | Fcor is expressed in white adipose tissue and brown adipose tissue. | |
| CDB0447T （RBRC05278） |
HB-EGFm | Masato Kasuga | Fukatsu T, Noguchi T, Hossoka T, Ogura T, Kotani K, Abe T, Shibakusa T, Inoue K, Sakai M, Tobimatsu K, Inagaki K, Yoshioka T, Matsuo M, Nakae J, Matsuki Y, Hiramatsu R, Kaku K, Okamura H, Fushiki T, Kasuga M. Muscle-Specific Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Increases Peripheral Glucose Disposal and Insulin Sensitivity. Endcrinology. 150(6), 2683-2691(2009). | ||
| CDB0449T （RBRC05279） |
I7(RDY)-ires-Nrp1-ires-gap-ECFP：IANC | Hitoshi Sakano | Imai, T., Yamazaki, T., Kobayakawa, R., Abe, T., Suzuki, M., and Sakano, H. (2009) Pre-target axon sorting establishes the neural map topography. Science, 325(5940), 585-590. | "A mutant-type odorant receptor, I7(D126R/R127D), Neuropilin-1, and an axonal marker gene, gap-ECFP, are expressed under MOR23 (Olfr16) gene promoter. I7(D126R/R127D) mutant is defective in G protein coupling. Control strains are RBRC02931 and RBRC02933 (deposited to RIKEN BRC)." | |
| CDB0450T （RBRC03510） |
aP2/Δ256Foxo1 | Masato Kasuga | Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K., Lombes, M. and Hayashi, Y. Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure. DIABETES: 57, 563-576, 2008. | A transactivation-defective Foxo1 (D256Foxo1) is expressed in adipose tissue | |
| CDB0452T | Ednrb-KikGR | Hideki Enomoto | Nishiyama C, Uesaka T, Manabe T, Yonekura Y, Nagasawa T, Newgreen DF, Young, HM, Enomoto H. (2012) Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system. Nat Neurosci. 15(9):1211-8. | KikumeGR is expressed under the promoter/enhancer region of the Ednrb gene. | |
| CDB0453T | pCAG-mito-Venus #25 | Anthony C.F. Perry | Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E. and Perry, A.C.F. (2006). Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. EMBO J. 25, 834-845. | Express Venus in mitochondria | |
| CDB0454T | pCAG-Plcz-IRES-Venus CS44 | Anthony C.F. Perry | Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. | Express phospholipase C ubiquitously | |
| CDB0455T | pCAG-Plcs-ct-Venus CV11 | Anthony C.F. Perry | Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. | Express phospholipase C ubiquitously | |
| CDB0456T | pCAG-Plcz-IRES-Venus CS42 | Anthony C.F. Perry | Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. | Express phospholipase C ubiquitously | |
| CDB0457T | pCAG-Plcz-IRES-Venus CS45 | Anthony C.F. Perry | Yoshida N, Amanai M, Fukui T, Kajikawa E, et al. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Oct 12;134: 3941-3952. | Express phospholipase C ubiquitously | |
| CDB0458T | pCAG-mito-Venus #19 | Anthony C.F. Perry | Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E. and Perry, A.C.F. (2006). Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. EMBO J. 25, 834-845. | Express Venus in mitochondria | |
| CDB0460T （RBRC05383） |
Prdm1(Blimp1)-mVenus | Mitinori Saitou | Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. | Venus targetted to plasma membrane is expressd under the control of Blimp1 regulatory elements | |
| CDB0461T （RBRC05384） |
Prdm14-mVenus | Mitinori Saitou | Yamaji, M., Seki, Y., Kurimoto, K., Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka, K., Ohinata, Y., and Saitou, M. (2008). Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nature Genetics, 40, 1016-1022. | Venus targetted to plasma membrane is expressd under the control of Prdm14 regulatory elements | |
| CDB0462T | stella-Venus | Mitinori Saitou | Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. | Venus is expressd under the control of stella regulatory elements | |
| CDB0463T | nanos3-EGFP | Mitinori Saitou | Yamaji, M., Tanaka, T., Shigeta, M., Chuma, S., Saga, Y., and Saitou, M. (2010). Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3. Reproduction, 139, 381-393. | nanos3-EGFP fusion protein (functional) is expressed under the control of nanos3 regulatory elements | |
| CDB0464T | Prdm1(Blimp1)-mKikGR | Mitinori Saitou | Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. (2009). A signaling principle for the specification of the germ cell lineage in mice. Cell, 137, 571-584. | KikGR targetted to plasma membrane is expressd under the control of Blimp1 regulatory elements | |
| CDB0465T （RBRC05382） |
stella-ECFP | Mitinori Saitou | Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008). A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter. Reproduction, 136, 503-514. | CFP is expressd under the control of stella regulatory elements | |
| CDB0467T | Kd-B6 | Ryotaro Yoshida | Yoshihiro Inoue, Junko Tashiro-Yamaji, Michihiro Hayashi, Hiroshi Kiyonari,Tetsunosuke Shimizu, Minenori Ibata, Hidenori Yamana, Takahiro Kubota, Nobuhiko Tanigawa and Ryotaro Yoshida. Transgene number-dependent, gene expression rate-independent rejection of Dd-, Kd-, or DdKd-transgened mouse skin or tumor cells from C57BL/6 (DbKb) mice.:Microbiology and Immunology. 55, 446-453, 2011. | Cosmid (for Dd) or cDNA (for Kd) is derived from BALB/c mice or BALB/c T-cell line. | |
| CDB0468T | Dd-B6 | Ryotaro Yoshida | Yoshihiro Inoue, Junko Tashiro-Yamaji, Michihiro Hayashi, Hiroshi Kiyonari,Tetsunosuke Shimizu, Minenori Ibata, Hidenori Yamana, Takahiro Kubota, Nobuhiko Tanigawa and Ryotaro Yoshida. Transgene number-dependent, gene expression rate-independent rejection of Dd-, Kd-, or DdKd-transgened mouse skin or tumor cells from C57BL/6 (DbKb) mice.:Microbiology and Immunology. 55, 446-453, 2011. | Cosmid (for Dd) or cDNA (for Kd) is derived from BALB/c mice or BALB/c T-cell line. | |
| CDB0476T | pCAGGS-Kif14 | Toshiaki Sakisaka | Kohei Fujikura, Tomiyoshi Setsu, Kenji Tanigaki, Takaya Abe, Hiroshi Kiyonari, Toshio Terashima, Toshiaki Sakisaka., Kif14 Mutation Causes Severe Brain Malformation and Hypomyelination.(2013) PLoS ONE 8(1): e53490. doi:10.1371/journal.pone.0053490. | Kif14 is expressed ubiquitously. | |
| CDB0479T | CaMKⅡa-E4BP4 | Kamon Sanada | Tamai S, Imaizumi K, Kurabayashi N, Nguyen MD, Abe T, Inoue M, Fukada Y Sanada K. (2014) Neuroprotective role of the basic leucine zipper transcription factor NFIL3 in models of amyotrophic lateral sclerosis. J Biol Chem. 289(3): 1629-1638. | "CaMKIIa-E4BP4-1：E4BP4 is expressed under the control of CaMKIIa promoter CaMKIIa-E4BP4-2：E4BP4 is expressed under the control of CaMKIIa promoter" | |
| CDB0480T | aP2-hGpr43/Ffar2 | Ikuo Kimura | Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013;4:1829. | human Gpr43/Ffar2 is expressed in adipose tissues by aP2 promoter | |
| CDB0481T | Aid-cre cd2 | Tasuku Honjo | Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. | Cre and human CD2 are expressed about 35% of germinal center B cells from an Aicda reporter transgene. | |
| CDB0482T | dCEBP-ac-cre | Tasuku Honjo | Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. | The mouse carries an inactivated Aicda transgene due to the deletion of CEB/P binding site in the region 4 enhancer. | |
| CDB0483T | dR4-ac-cre | Tasuku Honjo | Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. | The mouse carries an inactivated Aicda transgene due to the deletion of the region 4 enhancer. | |
| CDB0484T | dR2-ac-cre | Tasuku Honjo | Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One. 2013 Apr 16;8(4):e61433. doi: 10.1371/journal.pone.0061433. Print 2013. | The mouse carries an inactivated Aicda transgene due to the deletion of the region 2 enhancer. | |
| CDB0485T | γ2pepV | Tomoo Hirano | Tanaka S, Kawaguchi S, Shioi S, Hirano T. Long-term Potentiation of Inhibitory Synaptic Transmission onto Cerebellar Purkinje Neurons Contributes to Adaptation of Vestibulo-Ocular Reflex. The Journal of Neuroscience. 2013; 33(43):17209-17220. | γ2 peptide which blocks binding of GABA(A) receptor γ2 subunit and GABARAP is selectively expressed in cerebellar Purkinje neurons. | |
| CDB0486T | mVenus-p27K | Toshio Kitamura | Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T. (2014) A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012. doi: 10.1038/srep04012 | A G0 marker is expressed by CAG promoter; expression is strong in muscle cells | |
| CDB0489T | #123-Fez-lgVpA |
Masahiko Hibi | Hirata, T. Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons reguolates development of the olfactory bulb non-cell-autonomously. Development 133, 1433-1443. | Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, Yoshihara Y. Goofy coordinates the acuity of olfactory signaling. J Neurosci. 2013 Aug 7;33(32):12987-12996. | The transgenic mice express Fezf1 in olfactory and vomeronasal sensory neurons under the control of Goofy promoter |
| CDB0490T | Neurog2-d4Venus | Takaki Miyata | Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T. (2014) Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Dev Growth Differ. 56(4):293-304. doi:10.1111/dgd.12131. | d4Venus is expressed under the control of Neurog2 enhancer/promoter | |
| CDB0491T | Gadd45g-d4venus | Takaki Miyata | Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T. (2014) Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Dev Growth Differ. 56(4):293-304. doi:10.1111/dgd.12131. | d4Venus is expressed under the control of Gadd45g enhancer/promoter | |
| CDB0503T （RBRC11321） |
Gpnmb | Jun Wada | Katayama, A., Nakatsuka, A., Eguchi, J., Murakami, K., Teshigawara, S., Kanzaki, M., Nunoue, T., Hida, K., Wada, N., Yasunaka, T., Ikeda, F., Takaki, A., Yamamoto, K., Kiyonari, H., Makino, H. and Wada, J. (2015) Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis. Sci Rep. 5:16920. doi:10.1038/srep16920. | Gpnmb is expressed in macrophages and adipocytes. | |
| CDB0510T | Neurod1CreER(D1B) | Tatsumi Hirata | Hirata T, Tohsato Y, Itoga H, Shioi G, Kiyonari H, Oka S, Fujimori T, Onami S (2021) NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons. Cell Rep Methods 1(3): 100012 | A neurogenic tagging CreER driver designed for tamoxifen administration to induce loxP recombination in a neuronal birthdate-dependent manner | |
| CDB0511T | Neurod4CreER(D4A) | Tatsumi Hirata | Hirata T, Tohsato Y, Itoga H, Shioi G, Kiyonari H, Oka S, Fujimori T, Onami S (2021) NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons. Cell Rep Methods 1(3): 100012 | A neurogenic tagging CreER driver designed for tamoxifen administration to induce loxP recombination in a neuronal birthdate-dependent manner | |
| CDB0512T | Neurog2CreER(G2A) | Tatsumi Hirata | Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019. | Neuronal birthdate tag driver designed for TM administration to induce recombination of loxP sequences in a neuronal birthdate-dependent manner | |
| CDB0516T | inducible cardiospecific mutant TG of LTCC beta2a subunit | Hiroyuki Nakayama | Tonegawa K, Otsuka W, Kumagai S, Matsunami S, Hayamizu N, Tanaka S, Moriwaki K, Obana M, Maeda M, Asahi M, Kiyonari H, Fujio Y, Nakayama H. (2017) Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 312(3):H501-H514. | non-phosphorylatable mutant of LTCC beta2a subunit is expressed by the regulation of modified alpha-MHC promoter | |
| CDB0517T | Emu/miR142 | Hideki Nakakuma | Kuriyama K, Enomoto Y, Suzuki R, Watanuki J, Hosoi H, Yamashita Y, Murata S, Mushino T, Tamura S, Hanaoka N, Dyer M, Siebert R, Kiyonari H, Nakakuma H, Kitamura T, Sonoki T. (2017) Enforced expression of MIR142, a target of chromosome translocation in human B-cell tumors, results in B-cell depletion. Int J Hematol. doi: 10.1007/s12185-017-2360-8. | ||
| CDB0526T | Neurog1CreER(G1C) | Tatsumi Hirata | Hirata T, Tohsato Y, Itoga H, Shioi G, Kiyonari H, Oka S, Fujimori T, Onami S (2021) NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons. Cell Rep Methods 1(3): 100012 | A neurogenic tagging CreER driver designed for tamoxifen administration to induce loxP recombination in a neuronal birthdate-dependent manner | |
| CDB0532T | αMHC-TCTP | Takayuki Fujita | Wenqian Cai, Takayuki Fujita, Yuko Hidaka, Huiling Jin, Kenji Suita, Mayo Shigeta, Hiroshi Kiyonari, Masanari Umemura, Utako Yokoyama, Junichi Sadoshima & Yoshihiro Ishikawa. (2019) Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell Death & Diseasevolume 10, Article number: 549 (2019) | TCTP is expressed under the control of αMHC promoter. | |
| CDB0533T | inducuible PKAc α | Yasushi Fujio | Imaeda A, Tanaka S, Tonegawa K, Fuchigami S, Obana M, Maeda M, Kihara M, Kiyonari H, Conway SJ, Fujio Y, Nakayama H. (2019) Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice. Biochem Biophys Res Commun. 510(1):149-155. | This transgene carries the PKAcα downstream of CAG promoter and a floxed-CAT gene. PKAcα was overexpressed after excision of the floxed-CAT gene by Cre-mediated recombination. | |
| CDB0535T | Cdhr1tTA | Tatsumi Hirata | Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T. (2019) A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System. eNeuro 6(6). pii: ENEURO.0234-19.2019. | After Cre-loxP recombination, tTA is expressed in olfactory bulb projection neurons. | |
| CDB0536T | H-MOR28-iCre | Haruki Takeuchi | Ai Nakashima, Naoki Ihara, Mayo Shigeta, Hiroshi Kiyonari, Yuji Ikegaya, Haruki Takeuchi. (2019) Structured spike series specify gene expression patterns for olfactory circuit formation. Science Vol. 365, Issue 6448, eaaw5030 | Cre recombinase is expressed in MOR28 expressing olfactory sensory neurons. | |
| CDB0537T | H-I7-iCre | Haruki Takeuchi | Ai Nakashima, Naoki Ihara, Mayo Shigeta, Hiroshi Kiyonari, Yuji Ikegaya, Haruki Takeuchi. (2019) Structured spike series specify gene expression patterns for olfactory circuit formation. Science Vol. 365, Issue 6448, eaaw5030 | Cre recombinase is expressed in I7 expressing olfactory sensory neurons. | |
| CDB0539T | Acta2-LSL-mKO1 | Kouji Matsushima | Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K. (2019) Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis. Biochem Biophys Res Commun. 514(3):684-690. | This transgenic mouse line expresses monomeric Kusabira Orange 1 (mKO1) under Acta2 promoter after Cre recombination. Although the transgene includes dLNGFR-CreER sequence under Col1a2 enhancer, the mRNA of dLNGFR-CreER has not been detected and no CreER recombinase activity was obsereved in this mouse line itself so far. See the original article about the construct of transgene. The transgene is inserted on the Y chromosome. | |
| CDB0543T | RIP-UCP-2 | Yasuo Terauchi | Inoue R, Tsuno T, Togashi Y, Okuyama T, Sato A, Nishiyama K, Kyohara M, Li J, Fukushima S, Kin T, Miyashita D, Shiba Y, Atobe Y, Kiyonari H, Bando K, Shapiro AMJ, Funakoshi K, Kulkarni RN, Terauchi Y, Shirakawa J. (2022) Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER. iScience.25(7):104603. | Specific overexpression of Ucp2 in pancreatic β-cells | |
| CDB0546T | CAG/CATZ/OASIS(Creb3l1) | Masanori Obana | Miyake Y, Obana M, Yamamoto A, Noda S, Tanaka K, Sakai H, Tatsumoto N, Makino C, Kanemoto S, Shioi G, Tanaka S, Maeda M, Okada Y, Imaizumi K, Asanuma K, Fujio Y.(2022) Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis. Commun Biol. 5(1):734. | Breeding these mice with cre-expressing mice yields mice that overexpress the active form of OASIS in a cell-specific manner. | |
| CDB0547T | NFIA-Tg | Takashi Kadowaki | Hiraike Y, Saito K, Oguchi M, Wada T, Toda G, Tsutsumi S, Bando K, Sagawa J, Nagano G, Ohno H, Kubota N, Kubota T, Aburatani H, Kadowaki T, Waki H, Yanagimoto S, Yamauchi T (2023) NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis. Proc Natl Acad Sci U S A, 120(31):e2308750120. | A transgenic mice that overexpress 3xFLAG-tagged NFIA under the control of the −5.4 kb promoter/enhancer of the Fabp4 gene | |
| CDB0551T （RBRC02597） |
Hes7-Cre | Ryuichiro Kageyama | Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, Chu-Xia.and Kageyama, R. The Initiation and Propagation of Hes7 Oscillation Are Cooperatively Regulated by Fgf and Notch Signaling in the Somite Segmentation Clock. Dev Cell. . 13, 298-304, 2007 | Cre is expressed in the presomitic mesoderm and its derivatives. |
Genome Editing
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| CDB Acc.No. | Genetic Sign | mutation Type | Corresponding Researcher | Original paper |
|---|---|---|---|---|
| CDB0010E | Enpp1-EGFP-luciferase | KI | Takeshi Miyamoto | Arima T, Sugimoto K, Taniwaki T, Maeda K, Shibata Y, Tateyama M, Karasugi T, Tokunaga T, Sueyoshi T, Hisanaga S, Masuda T, Uehara Y, Yugami M, Matsushita K, Yonemitsu R, Kawakami J, Yoshimura N, Tanimura S, Kato H, Ito N, Inoue K, Bando K, Nakamura T, Miyamoto T.(2024) Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice. J Biol Chem. 300(1):105512. |
| CDB0030E | Bob1fl/+ | conditional | Shingo Ichimiya | Yanagi M, Ikegami I, Kamekura R, Sato T, Sato T, Kamiya S, Murayama K, Jitsukawa S, Ito F, Yorozu A, Kihara M, Abe T, Takaki H, Kawata K, Shigehara K, Miyajima S, Nishikiori H, Sato A, Tohse N, Takano KI, Chiba H, Ichimiya S. (2024) Bob1 maintains T follicular helper cells for long-term humoral immunity. Commun Biol.7(1):185. |
| CDB0032E | Tsukushi | conditional | Kunimasa Ohta | Ito, N., Riyadh, M. A., Ahmad, S. A. I., Hattori, S., Kanemura, Y., Kiyonari, H., Abe, T., Furuta, Y., Shinmyo, Y., Kaneko, N., Hirota, Y., Lupo, G., Hatakeyama, J., Abdulhaleem, M. F., Anam, M. B., Yamaguchi, M., Takeo, T., Takebayashi, H., Takebayashi, M., Oike, Y., Nakagata, N., Shimamura, K., Holtzman, M. J., Takahashi, Y., Guillemot, F., Miyakawa, T., Sawamoto, K., & Ohta, K. (2021). Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Sci Transl Med, 13(587). |
| CDB0033E | Camsap3 | KO | Masatoshi Takeichi | Mitsuhata, Y., Abe, T., Misaki, K., Nakajima, Y., Kiriya, K., Kawasaki, M., Kiyonari, H., Takeichi, M., Toya, M., & Sato, M. (2021). Cyst formation in proximal renal tubules caused by dysfunction of the microtubule minus-end regulator CAMSAP3. Sci Rep, 11(1), 5857. |
| CDB0034E | IL9r(interleukin 9 receptor) | conditional KO | Shingo Ichimiya | Kamiya S, Ikegami I ,Yanagi M ,Takaki H, Kamekura R, Sato T, Kobayashi K, Kamiya T, Kamada Y, Abe T, Inoue K, Hida T, Uhara H, Ichimiya S. (2022) Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation. J Invest Dermatol 142: 3222-3231.e5 |
| CDB0039E | Rab44 | KO (deletion) | Takayuki Tsukuba | Kadowaki T, Yamaguchi Y, Kido MA, Abe T, Ogawa K, Tokuhisa M, Gao W, Okamoto K, Kiyonari H, Tsukuba T.(2020) The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis. Cell Mol Immunol. doi: 10.1038/s41423-020-0413-z. |
| CDB0056E | Tacr3 | IRES-Cre KI | Tomomi Shimogori | Onishi, K., Kikuchi, S. S., Abe, T., Tokuhara, T., & Shimogori, T. (2021). Molecular cell identities in the mediodorsal thalamus of infant mice and marmoset. J Comp Neurol. |
| CDB0059E | I-PpoI | conditional KI | Kaori Hayashi | Nakamichi R, Hishikawa A, Chikuma S, Yoshimura A, Sasaki T, Hashiguchi A, Abe T, Tokuhara T, Yoshimoto N, Nishimura ES, Hama EY, Azegami T, Nakayama T, Hayashi K, Itoh H. (2023) DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation. Cell Rep 42 (4) : 112302. |
| CDB0065E | Atf3-KO | KO | Genshiro Sunagawa | Deviatiiarov R, Ishikawa K, Gazizova G, Abe T, Kiyonari H, Takahashi M, Gusev O, Sunagawa GA. (2021) Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle. Commun Biol. 4(1):1290. |
| CDB0102E | R26R-CAG-Smad7 | conditional KI | Tomomi Shimogori | Young TR, Yamamoto M, Kikuchi SS, Yoshida AC, Abe T, Inoue K, Johansen JP, Benucci A, Yoshimura Y, Shimogori T (2023) Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex. Nat Commun 14: 6077. |
| CDB0116E | Oxt-cKO | conditional | Kazunari Miyamichi | Inada K, Hagihara M, Tsujimoto K, Abe T, Konno A, Hirai H, Kiyonari H, Miyamichi K (2022) Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice. Neuron 110 (12) :2009-2023 e2005 |
| CDB0117E | PD1(hPD-1) C57BL/6N | KI | Akio Ohta | Suzuki K, Tajima M, Tokumaru Y, Oshiro Y, Nagata S, Kamada H, Kihara M, Nakano K, Honjo T, Ohta A (2023) Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases. Sci Immunol 8 (79): eadd4947 |
| CDB0120E | Rosa26-CAG-LSL-Sirt1-P2A-eGFP | KI, conditional overexpression | Mitsuru Morimoto | Enomoto Y, Katsura H, Fujimura T, Ogata A, Baba S, Yamaoka A, Kihara M, Abe T, Nishimura O, Kadota M, Hazama D, Tanaka Y, Maniwa Y, Nagano T, Morimoto M.(2023) Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis. Nat Commun. 14(1):4956. |
| CDB0137E | Fibrillarin/Flb conditional knockout(Flox) | KI（Fbl flox/+ NestinCreERT2) | Fumio Matsuzaki | Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, Iwasaki S, Matsuzaki F. (2022) Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun. 13(1):470. |
| CDB0154E | C1qa | KI | Kouji Matsushima | Ogawa T, Shichino S, Ueha S, Bando K, Matsushima K. (2022) Profibrotic properties of C1q + interstitial macrophages in silica-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 599:113-119. |
| CDB0204E | Oxt-KO | KO | Kazunari Miyamichi | Inada K, Hagihara M, Tsujimoto K, Abe T, Konno A, Hirai H, Kiyonari H, Miyamichi K (2022) Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice. Neuron 110 (12) :2009-2023 e2005 |