Reporter mouse

生体モデル開発チームでは、アカデミアに対しレポーターマウスの分与を行なっています。分与に際し、MTAを締結します。分与をご希望の方は、リクエストフォームに記入の上、mutant.bdr(at) にお送りください。


LARGE has recently developed a number of fluorescent reporter mouse lines useful for live imaging of embryos and tissues to aid better understanding of dynamic developmental processes. The following list of reporter mice are available to the scientific community.

Please contact “mutant.bdr(at)” to request the reporter mouse line of your interest.

Request Form
Reporter mouse list
Applications Line names CDB Acc. No. Ref.
Nucleus R26R-H2B-EGFP CDB0203K 1
Nucleus R26R-H2B-mCherry CDB0204K 1
Nucleus R26R-H2B-mKeima-Red CDB0205K 1
Nucleus R26-H2B-EGFP CDB0238K 1
Nucleus R26-H2B-mCherry CDB0239K 1
Nucleus R26-H2B-mKeima-Red CDB0240K 1
Mitochondria R26R-Mito-EGFP CDB0216K 1
Mitochondria R26-Mito-EGFP CDB0251K 1
Golgiapparatus R26R-Golgi-EGFP CDB0211K 1
Golgiapparatus R26R-Golgi-mCherry CDB0212K 1
Golgiapparatus R26-Golgi-EGFP CDB0246K 1
Golgiapparatus R26-Golgi-mCherry CDB0247K 1
Membrane R26R-Lyn-Venus CDB0219K 1
Membrane R26R-Display-Venus CDB0208K 1
Membrane R26R-Display-mCherry CDB0209K 1
Membrane R26R-Display-KikGR CDB0207K 1
Membrane R26-Lyn-Venus CDB0254K 1
Membrane R26-Display-Venus CDB0243K 1
Membrane R26-Display-mCherry CDB0244K 1
Membrane R26-Display-KikGR CDB0242K 1
Membrane R26R-Lyn-mCherry CDB0278K 2
Membrane R26-Lyn-mCherry CDB0287K 2
Microtubules R26R-EGFP-Tuba CDB0210K 1
Microtubules R26R-hEMTB-EGFP CDB0214K 1
Microtubules R26R-EB1-EGFP CDB0213K 1
Microtubules R26-EGFP-Tuba CDB0245K 1
Microtubules R26-hEMTB-EGFP CDB0249K 1
Microtubules R26-EB1-EGFP CDB0248K 1
Cytoplasm CAG-KikGR-1 CDB0201T-1 4
Cytoplasm CAG-KikGR-2 CDB0201T-2 4
Cytoplasm R26R-ManGeKyou (R26R-MGK) CDB0222K 11
Cytoplasm R26R-EGFP CDB0297K 11
Cytoplasm R26R-nKikGR CDB0312K 13
Cytoplasm R2R-nKikGR CDB0318K 13
Actin cytoskeleton R26R-Venus-Actin CDB0217K 1
Actin cytoskeleton R26R-Venus-Moesin CDB0221K 1
Actin cytoskeleton R26-Venus-Actin CDB0253K 1
Actin cytoskeleton R26-Venus-Moesin CDB0252K 1
Actin cytoskeleton R26R-EGFP-Toripbp4 CDB0280K 3
Actin cytoskeleton R26-EGFP-Toripbp4 CDB0289K 3
Tight junction R26R-ZO1-EGFP CDB0225K 12
Tight junction R26-ZO1-EGFP CDB0260K 12
Adherence junction R26R-PHA7-EGFP CDB0226K 9
Adherence junction R26-PHA7-EGFP CDB0261K 9
Nucleus & Membrane R26R-RG CDB0227K 2
Nucleus & Membrane R26-RG CDB0237K 2
Fucci2-G1 R26R-mCherry-hCdt1(30/120) CDB0229K 3
Fucci2-S/G2/M R26R-mVenus-hGem(1/110) CDB0230K 3
Fucci2 R26p-Fucci2 CDB0203T 3
Fucci2-G1 R26-mCherry-hCdt1(30/120) CDB0264K 3
Fucci2-S/G2/M R26-mVenus-hGem(1/110) CDB0265K 3
Wnt signaling pathway R26-WntVis CDB0303K 8
ERK FRET senssor R26R-EKAREV-NES CDB0306K 10
ERK FRET senssor R26R-EKAREV-NLS CDB0307K 10
  • Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging.
    Abe T, Kiyonari H, Shioi G, Inoue K, Nakao K, Aizawa S, Fujimori T.
    Genesis.2011 Jul;49(7):579-90.
    PMID: 21445964
  • A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging.
    Shioi G, Kiyonari H, Abe T, Nakao K, Fujimori T, Jang CW, Huang CC, Akiyama H, Behringer RR, Aizawa S.
    Genesis.2011 Jul;49(7):570-8.
    PMID: 21504045
  • Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter.
    Abe T, Sakaue-Sawano A, Kiyonari H, Shioi G, Inoue K, Horiuchi T, Nakao K, Miyawaki A, Aizawa S, Fujimori T.
    Development.2013 Jan 1;140(1):237-46.
    PMID: 23175634
  • Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape.
    Kurotaki Y1, Hatta K, Nakao K, Nabeshima Y, Fujimori T.
    Science.2007 May 4;316(5825):719-23.
    PMID: 17446354
  • Reporter mouse lines for fluorescence imaging.
    Abe T, Fujimori T.
    Dev Growth Differ.2013 May;55(4):390-405. Review.
    PMID: 23621623
  • Live imaging of early mouse embryos using fluorescently labeled transgenic mice.
    Abe T, Aizawa S, Fujimori T.
    Methods Mol Biol.2013;1052:101-8.
    PMID: 23674079
  • Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium.
    Katsunuma S, Honda H, Shinoda T, Ishimoto Y, Miyata T, Kiyonari H, Abe T, Nibu K, Takai Y, Togashi H.
    J Cell Biol.2016 Feb 29;212(5):561-75.
    PMID: 26929452
  • R26-WntVis reporter mice showing graded response to Wnt signal levels.
    Takemoto T, Abe T, Kiyonari H, Nakao K, Furuta Y, Suzuki H, Takada S, Fujimori T, Kondoh H.
    Genes Cells.2016 Jun;21(6):661-9.
    PMID: 27030109
  • Apical constriction in distal visceral endoderm cells initiates global, collective cell rearrangement in embryonic visceral endoderm to form anterior visceral endoderm.
    Shioi, G., Hoshino, H., Abe, T., Kiyonari, H., Nakao, K., Meng, W., Furuta, Y., Fujimori, T., and Aizawa, S.
    Developmental biology2017 Sep 1;429(1):20-30
    PMID: 28712875
  • Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility
    Konishi, Y., Terai, K., Fruta, Y., Kiyonari, H., Abe, T., Ueda, Y., Kinashi, T., Hamazaki, Y., Takaori-Kondo, A., and Matsuda, M.
    iSicence2018 Dec 21;10:98-113
  • ROSA26 reporter mouse lines and image analyses reveal the distinct region-specific cell behaviors in the visceral endoderm
    Abe, T., Kutsuna, N., Kiyonari, H., Furuta, Y.,and Fujimori, T.
    Development2018 Nov 21;145(22)
    PMID: 30327323
  • Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins
    Kiyonari, H., Kaneko, M., Abe, T., Shioi, G., Aizawa, S., Furuta, Y., Fujimori, T.
    genesis2018 Feb; 57(2):e23277
    PMID: 30597711
  • Tracing the origin of hair follicle stem cells
    Morita, R., Sanzen, N., Sasaki, H., Hayashi, T., Umeda, M., Yoshimura, M., Yamamoto, T., Shibata, T., Abe, T., Kiyonari, H., Furuta, Y., Nikaido, I., Fujiwara, H.
    Nature2021 Jun; 594(7864):547-552
    PMID: 34108685